Bilayer Effects of Antimalarial Compounds

How do antimalarial drugs reach their intracellular targets?

(2015) Katherine Basore et al.   Frontiers in Pharmacology

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum Aminopeptidases, M1, M17 and M18

(2015) Alessandro Paiardini et al.   PLoS One

Phytochemicals Perturb Membranes and Promiscuously Alter Protein Function

(2014) Helgi I. Ingólfsson et al.   ACS Chemical Biology

Repurposing the Open Access Malaria Box To Discover Potent Inhibitors of Toxoplasma gondii and Entamoeba histolytica

(2014) Fabrice F. Boyom et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Target evaluation of deoxyhypusine synthase from Theileria parva the neglected animal parasite and its relationship to Plasmodium

(2014) James T. Njuguna et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties

(2014) Karl F. Herold et al.   JOURNAL OF GENERAL PHYSIOLOGY

Identification of an Atg8-Atg3 Protein–Protein Interaction Inhibitor from the Medicines for Malaria Venture Malaria Box Active in Blood and Liver Stage Plasmodium falciparum Parasites

(2014) Adelaide U.P. Hain et al.   JOURNAL OF MEDICINAL CHEMISTRY

A novel approach for the discovery of chemically diverse anti-malarial compounds targeting the Plasmodium falciparum Coenzyme A synthesis pathway

(2014) Sabine Fletcher et al.   MALARIA JOURNAL

Identification of MMV Malaria Box Inhibitors of Perkinsus marinus Using an ATP-Based Bioluminescence Assay

(2014) Yesmalie Alemán Resto et al.   PLoS One

Identification of MMV Malaria Box Inhibitors of Plasmodium falciparum Early-Stage Gametocytes Using a Luciferase-Based High-Throughput Assay

(2013) Leonardo Lucantoni et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Small-Molecule Photostabilizing Agents are Modifiers of Lipid Bilayer Properties

(2013) Jose L. Alejo et al.   BIOPHYSICAL JOURNAL

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

(2013) Thomas Spangenberg et al.   PLoS One

Whole Cell Screen for Inhibitors of pH Homeostasis in Mycobacterium tuberculosis

(2013) Crystal M. Darby et al.   PLoS One

Ion and nutrient uptake by malaria parasite-infected erythrocytes

(2012) Sanjay A. Desai   CELLULAR MICROBIOLOGY

Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation

(2012) Michael J. Bruno et al.   FARADAY DISCUSSIONS

Hits, leads and drugs against malaria through diversity-oriented synthesis

(2012) Sivaraman Dandapani et al.   Future Medicinal Chemistry

Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study

(2012) Aung Pyae Phyo et al.   LANCET

Quantifying the chemical beauty of drugs

(2012) G. Richard Bickerton et al.   Nature Chemistry

Thiazolidinedione insulin sensitizers alter lipid bilayer properties and voltage-dependent sodium channel function: implications for drug discovery

(2011) Radda Rusinova et al.   JOURNAL OF GENERAL PHYSIOLOGY

A Research Agenda for Malaria Eradication: Drugs

(2011)   PLOS MEDICINE

Screening for Small Molecules' Bilayer-Modifying Potential Using a Gramicidin-Based Fluorescence Assay

(2010) Helgi I. Ingólfsson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Antimicrobial and Membrane Disrupting Activities of a Peptide Derived from the Human Cathelicidin Antimicrobial Peptide LL37

(2010) Sathiah Thennarasu et al.   BIOPHYSICAL JOURNAL

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Determining the Effects of Lipophilic Drugs on Membrane Structure by Solid-State NMR Spectroscopy: The Case of the Antioxidant Curcumin

(2009) Jeffrey Barry et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes

(2009) J. A. Lundbaek et al.   Journal of the Royal Society Interface

Lipid Bilayer–mediated Regulation of Ion Channel Function by Amphiphilic Drugs

(2008) Jens A. Lundbæk   JOURNAL OF GENERAL PHYSIOLOGY

Lipid Vesicles as Membrane Models for Toxicological Assessment of Xenobiotics

(2007) Helmut H. Zepik et al.   CRITICAL REVIEWS IN TOXICOLOGY