Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1–42 induced neurotoxicity and memory impairment
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1–42 induced neurotoxicity and memory impairment
Authors
Keywords
-
Journal
Scientific Reports
Volume 6, Issue 1, Pages -
Publisher
Springer Nature
Online
2016-05-04
DOI
10.1038/srep25226
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Ghrelin Ameliorates Cognitive Dysfunction and Neurodegeneration in Intrahippocampal Amyloid-β1-42 Oligomer-Injected Mice
- (2018) Minho Moon et al. JOURNAL OF ALZHEIMERS DISEASE
- Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia
- (2016) Antonio Carlos Pinheiro de Oliveira et al. Journal of Neuroinflammation
- Inhibition of the phosphoinositide 3-kinase pathway for the treatment of patients with metastatic metaplastic breast cancer
- (2015) S. Moulder et al. ANNALS OF ONCOLOGY
- Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against osteosarcoma
- (2015) Yun-Rong Zhu et al. CANCER BIOLOGY & THERAPY
- PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine
- (2015) Isabel Vieira de Assis Lima et al. EXPERIMENTAL NEUROLOGY
- Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology
- (2015) Marie-Victoire Guillot-Sestier et al. NEURON
- IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior
- (2015) Paramita Chakrabarty et al. NEURON
- mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation
- (2015) K He et al. ONCOGENE
- Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system
- (2015) Paul S. Baxter et al. Nature Communications
- The Dual PI3K/mTOR Inhibitor NVP-BEZ235 Is a Potent Inhibitor of ATM- and DNA-PKCs-Mediated DNA Damage Responses
- (2015) Bipasha Mukherjee et al. NEOPLASIA
- Trafficking regulation of proteins in Alzheimer’s disease
- (2014) Shangtong Jiang et al. Molecular Neurodegeneration
- RIPK3 as a potential therapeutic target for Gaucher's disease
- (2014) Einat B Vitner et al. NATURE MEDICINE
- Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors
- (2014) Andrea Crotti et al. NATURE NEUROSCIENCE
- Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans
- (2014) H. Ohno et al. SCIENCE
- Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy
- (2014) K. G. Akers et al. SCIENCE
- NCYM, a Cis-Antisense Gene of MYCN, Encodes a De Novo Evolved Protein That Inhibits GSK3β Resulting in the Stabilization of MYCN in Human Neuroblastomas
- (2014) Yusuke Suenaga et al. PLoS Genetics
- Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP
- (2013) Ari Robinson et al. AGING CELL
- Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease
- (2013) JG Doria et al. BRITISH JOURNAL OF PHARMACOLOGY
- Discovering and targeting the basic mechanism of neurodegeneration: The role of peptides from the C-terminus of acetylcholinesterase
- (2013) Susan Greenfield CHEMICO-BIOLOGICAL INTERACTIONS
- PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease
- (2013) Cora O' Neill EXPERIMENTAL GERONTOLOGY
- Alzheimer's Disease Neurodegenerative Biomarkers Are Associated with Decreased Cognitive Function but Not -Amyloid in Cognitively Normal Older Individuals
- (2013) M. Wirth et al. JOURNAL OF NEUROSCIENCE
- Estradiol-induced object recognition memory consolidation is dependent on activation of mTOR signaling in the dorsal hippocampus
- (2013) A. M. Fortress et al. LEARNING & MEMORY
- mTOR complexes in neurodevelopmental and neuropsychiatric disorders
- (2013) Mauro Costa-Mattioli et al. NATURE NEUROSCIENCE
- Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 Has a Therapeutic Potential and Sensitizes Cisplatin in Nasopharyngeal Carcinoma
- (2013) Fen Yang et al. PLoS One
- Recent developments of protein kinase inhibitors as potential AD therapeutics
- (2013) Volkmar Tell et al. Frontiers in Cellular Neuroscience
- Neprilysin and Aβ Clearance: Impact of the APP Intracellular Domain in NEP Regulation and Implications in Alzheimer’s Disease
- (2013) Marcus O. W. Grimm et al. Frontiers in Aging Neuroscience
- Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1-42-induced rat model of Alzheimer’s disease
- (2013) Xiao-Hong Li et al. Clinical Interventions in Aging
- False recognition in a mouse model of Alzheimer's disease: rescue with sensory restriction and memantine
- (2012) C. Romberg et al. BRAIN
- Targeting disease through novel pathways of apoptosis and autophagy
- (2012) Kenneth Maiese et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Interleukin-6, a Major Cytokine in the Central Nervous System
- (2012) María Erta et al. International Journal of Biological Sciences
- PI3K Mediates Stretch-Induced COX-2 Expression During Urinary Tract Obstruction
- (2012) Kwadwo Owusu-Ofori et al. JOURNAL OF ENDOUROLOGY
- Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia
- (2012) Antonio CP de Oliveira et al. Journal of Neuroinflammation
- Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in beta-amyloid rat model of Alzheimer’s disease
- (2012) Aiguo Xuan et al. Journal of Neuroinflammation
- Tumor necrosis factor-α synthesis inhibitor 3,6′-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer’s disease
- (2012) David Tweedie et al. Journal of Neuroinflammation
- Mammalian target of rapamycin: A valid therapeutic target through the autophagy pathway for alzheimer's disease?
- (2012) Zhiyou Cai et al. JOURNAL OF NEUROSCIENCE RESEARCH
- PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial–mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis
- (2012) Guo-Qing Li et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Genetic Knockdown of Brain-Derived Neurotrophic Factor in 3xTg-AD Mice Does Not Alter Aβ or Tau Pathology
- (2012) Nicholas A. Castello et al. PLoS One
- Identification of Druggable Targets for Radiation Mitigation Using a Small Interfering RNA Screening Assay
- (2012) Crystal D. Zellefrow et al. RADIATION RESEARCH
- A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines
- (2012) Jose Miguel Rubio-Perez et al. TheScientificWorldJOURNAL
- Whole Animal Perfusion Fixation for Rodents
- (2012) Gregory J. Gage et al. Jove-Journal of Visualized Experiments
- Diverse Inflammatory Responses in Transgenic Mouse Models of Alzheimer's Disease and the Effect of Immunotherapy on These Responses
- (2011) Donna M Wilcock et al. ASN Neuro
- Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice
- (2011) Yoko Furukawa-Hibi et al. BEHAVIOURAL BRAIN RESEARCH
- AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice
- (2011) T Kiyota et al. GENE THERAPY
- Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
- (2011) Dan Zhang et al. Journal of Neuroinflammation
- Physiology of Microglia
- (2011) Helmut Kettenmann et al. PHYSIOLOGICAL REVIEWS
- DMXB (GTS-21) ameliorates the cognitive deficits in beta amyloid25-35−injected mice through preventing the dysfunction of alpha7 nicotinic receptor
- (2010) Lei Chen et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Alzheimer's Disease
- (2010) Henry W. Querfurth et al. NEW ENGLAND JOURNAL OF MEDICINE
- A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1
- (2009) Jingxiang Huang et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Involvement of phosphoinositide 3-kinase γ in the neuro-inflammatory response and cognitive impairments induced by β-amyloid 1–40 peptide in mice
- (2009) Giselle F. Passos et al. BRAIN BEHAVIOR AND IMMUNITY
- Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts
- (2009) P Cao et al. BRITISH JOURNAL OF CANCER
- Adenosine A2A Receptor Blockade Prevents Synaptotoxicity and Memory Dysfunction Caused by -Amyloid Peptides via p38 Mitogen-Activated Protein Kinase Pathway
- (2009) P. M. Canas et al. JOURNAL OF NEUROSCIENCE
- The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events
- (2009) Kiran Bhaskar et al. Molecular Neurodegeneration
- Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology
- (2009) Fiona E. McAlpine et al. NEUROBIOLOGY OF DISEASE
- NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations
- (2008) V. Serra et al. CANCER RESEARCH
- Microglial Dysfunction and Defective -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
- (2008) S. E. Hickman et al. JOURNAL OF NEUROSCIENCE
- Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
- (2008) S.-M. Maira et al. MOLECULAR CANCER THERAPEUTICS
- The anti-amnesic and neuroprotective effects of donepezil against amyloid β25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor
- (2006) J Meunier et al. BRITISH JOURNAL OF PHARMACOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now