Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia

Different mechanisms of apolipoprotein E isoform–dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia

(2015) Xianwu Li et al.   FASEB JOURNAL

The Poly(I:C)-induced maternal immune activation model in preclinical neuropsychiatric drug discovery

(2015) Sonali Reisinger et al.   PHARMACOLOGY & THERAPEUTICS

Synoviocyte Innate Immune Responses: I. Differential Regulation of Interferon Responses and the JNK Pathway by MAPK Kinases

(2014) T. Yoshizawa et al.   JOURNAL OF IMMUNOLOGY

Targeting Poly(I:C) to the TLR3-Independent Pathway Boosts Effector CD8 T Cell Differentiation through IFN- / 

(2014) S. M. Ngoi et al.   JOURNAL OF IMMUNOLOGY

RIG-1 receptor expression in the pathology of Alzheimer’s disease

(2014) Juan de Rivero Vaccari et al.   Journal of Neuroinflammation

Histone deacetylase inhibitors valproic acid and sodium butyrate enhance prostaglandins release in lipopolysaccharide-activated primary microglia

(2014) V. Singh et al.   NEUROSCIENCE

IRF3 and ERK MAP-kinases control nitric oxide production from macrophages in response to poly-I:C

(2013) Tyler C. Moore et al.   FEBS LETTERS

Spinal Toll-like receptor signaling and nociceptive processing: Regulatory balance between TIRAP and TRIF cascades mediated by TNF and IFNβ

(2013) Jennifer A. Stokes et al.   PAIN

Evidences for a progressive microglial activation and increase in iNOS expression in rats submitted to a neurodevelopmental model of schizophrenia: Reversal by clozapine

(2013) Bruna Mara Machado Ribeiro et al.   SCHIZOPHRENIA RESEARCH

Toll-like receptor 3 activation promotes desensitization of histamine response in human gingival fibroblasts

(2012) Gloria Gutiérrez-Venegas et al.   CELLULAR IMMUNOLOGY

Immunological Treatment Options for Schizophrenia

(2012) Norbert Muller et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Eicosanoid receptor subtype-mediated opposing regulation of TLR-stimulated expression of astrocyte glial-derived neurotrophic factor

(2012) Xianwu Li et al.   FASEB JOURNAL

Viral-toxin interactions and Parkinson’s disease: poly(I:C) priming enhanced the neurodegenerative effects of paraquat

(2012) Jessica Bobyn et al.   Journal of Neuroinflammation

Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia

(2012) Antonio CP de Oliveira et al.   Journal of Neuroinflammation

Emerging role of Toll-like receptors in the control of pain and itch

(2012) Tong Liu et al.   Neuroscience Bulletin

Prenatal activation of Toll-like receptors-3 by administration of the viral mimetic poly(I:C) changes synaptic proteins, N-methyl-D-aspartate receptors and neurogenesis markers in offspring

(2012) Caroline M Forrest et al.   Molecular Brain

Aspects of Innate Immunity and Parkinson’s Disease

(2012) Yue Huang et al.   Frontiers in Pharmacology

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Toll-like receptor 3-elicited MAPK activation induces stabilization of interferon-β mRNA

(2011) Ingvild Bjellmo Johnsen et al.   CYTOKINE

A synthetic double-stranded RNA, poly I:C, induces a rapid apoptosis of human CD34+ cells

(2011) Jiajia Liu et al.   EXPERIMENTAL HEMATOLOGY

Suppressed microglial E prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation

(2011) Xianwu Li et al.   GLIA

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway

(2011) Leonid Tarassishin et al.   Journal of Neuroinflammation

Spinal Toll like Receptor 3 is Involved in Chronic Pancreatitis-Induced Mechanical Allodynia of Rat

(2011) Nian-Song Qian et al.   Molecular Pain

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration

(2010) Robert Field et al.   BRAIN BEHAVIOR AND IMMUNITY

Activation of the NLRP3 inflammasome by intracellular poly I:C

(2010) Jayant V. Rajan et al.   FEBS LETTERS

Suppressive Effects of Procaterol on Expression of IP-10/CXCL 10 and RANTES/CCL 5 by Bronchial Epithelial Cells

(2010) Ka-Pan Lam et al.   INFLAMMATION

Akt Contributes to Activation of the TRIF-Dependent Signaling Pathways of TLRs by Interacting with TANK-Binding Kinase 1

(2010) S. M. Joung et al.   JOURNAL OF IMMUNOLOGY

The Toll-Like Receptor-3 Agonist Polyinosinic:Polycytidylic Acid Triggers Nigrostriatal Dopaminergic Degeneration

(2010) M. Deleidi et al.   JOURNAL OF NEUROSCIENCE

The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells

(2010) Sandra Ribes et al.   NEUROSCIENCE LETTERS

TLR3 and TLR4 are innate antiviral immune receptors in human microglia: Role of IRF3 in modulating antiviral and inflammatory response in the CNS

(2009) Hyeon-Sook Suh et al.   VIROLOGY

Toll-like receptors in neurodegeneration

(2008) Eitan Okun et al.   BRAIN RESEARCH REVIEWS

Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: Evidence for uncoupled regulation of mPGES-1 and COX-2

(2008) Antonio Carlos Pinheiro de Oliveira et al.   GLIA

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

poly(I:C) and LPS induce distinct IRF3 and NF-κB signaling during type-I IFN and TNF responses in human macrophages

(2008) Thornik Reimer et al.   JOURNAL OF LEUKOCYTE BIOLOGY