Article
Plant Sciences
Ying Feng, Han Dong, Liyan Zheng
Summary: Ligustrazine was found to inhibit inflammation in Endometriosis (EMs) by regulating the STAT3/IGF2BP1/RELA axis. These findings propose a new agent against EMs and support the development of ligustrazine-based treatment strategies for EMs.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ana Claudia Lima, Diana Amorim, Ines Laranjeira, Armando Almeida, Rui L. Reis, Helena Ferreira, Filipa Pinto-Ribeiro, Nuno M. Neves
Summary: The immobilization of anti-TNF-α and anti-IL-6 antibodies on polymeric nanoparticles extended and increased therapeutic efficacy while avoiding off-target effects. Biofunctionalized nanoparticles showed greater efficiency in reducing inflammation compared to soluble antibodies, offering a promising therapeutic option for inflammatory conditions with a safe profile and prolonged action.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Leanne Mooney, Colette E. Jackson, Carly Adamson, Alex McConnachie, Paul Welsh, Rachel C. Myles, John J. V. McMurray, Pardeep S. Jhund, Mark C. Petrie, Ninian N. Lang
Summary: Circulating levels of interleukin-6 may identify patients at greater risk of adverse outcomes following hospitalization with heart failure with preserved ejection fraction.
CIRCULATION-HEART FAILURE
(2023)
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Areej Al-Roub, Ashraf Al Madhoun, Nadeem Akhter, Reeby Thomas, Lavina Miranda, Texy Jacob, Ebaa Al-Ozairi, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Summary: The overexpression of IL-6 in the adipose tissue of obese individuals may lead to insulin resistance. IL-1 beta and TNF alpha, which are increased in obese adipose tissue, cooperate to enhance the production of IL-6 in adipocytes. This cooperative interaction depends on CREB binding and H3K14 acetylation and provides an interesting pathophysiological connection among IL-1 beta, TNF alpha, and IL-6 in obesity settings.
Article
Medicine, General & Internal
Alireza Peyman, Mohammad Namgar, Awat Feizi, Mazdak Ganjalikhani Hakemi, Fahimeh Hosseini Nasab, Mohsen Pourazizi
Summary: The study found that levels of tumor necrosis factor-alpha and interleukin-6 in tears of patients with keratoconus were significantly higher compared to healthy controls, and these inflammatory markers were associated with the severity of the disease.
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Panagiotis Tsioufis, Panagiotis Theofilis, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: Coronary atherosclerosis is a chronic disease involving inflammation, endothelial dysfunction, and lipoprotein dysregulation. Inflammatory cytokines, such as interleukins, tumor necrosis factor-alpha, and chemokines, play a role in the development and progression of coronary artery disease. Targeting these cytokines with drugs like IL-1 beta and colchicine has shown promise in reducing cardiovascular risk. Other cytokine-targeted treatments are being explored, but more research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Qing-Qing Yang, Hao-Nan Li, Yu-Tong Xia, Xue Tian, Fan Feng, Jian Yang, Ya-Li Xu, Juan Guo, Xiao-Qi Li, Jun-Yang Wang, Xiao-Yan Zeng
Summary: Our study reveals that rubral interleukin-6 (IL-6) plays a role in descending facilitation and pain sensation through the activation of JAK2/STAT3 and/or ERK pathways, resulting in the upregulation of spinal pro-inflammatory cytokines and downregulation of spinal anti-inflammatory cytokines. These findings provide potential therapeutic targets for the treatment of pathological pain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Stefan Teufel, Petra Koeckemann, Christine Fabritius, Lena Wolff, Jessica Bertrand, Thomas Pap, Christine Hartmann
Summary: Agonists and antagonists of the canonical Wnt signaling pathway have an impact on rheumatoid arthritis, primarily modifying bone loss and soft-tissue inflammation. WNT9a levels are elevated in the pannus tissue of RA patients, suggesting a specific role in TNF-triggered RA.
CELL DEATH & DISEASE
(2021)
Article
Psychiatry
Rajesh Das, Md. Prova Zaman Emon, Mohammad Shahriar, Zabun Nahar, Sardar Mohammad Ashraful Islam, Mohiuddin Ahmed Bhuiyan, Sheikh Nazrul Islam, Md. Rabiul Islam
Summary: The study found that serum IL-1 beta and TNF-alpha levels are increased in MDD patients and are positively correlated with the severity of depression. Elevated levels of serum IL-1 beta and TNF-alpha could potentially be used as risk assessment indicators for depression.
PSYCHIATRY RESEARCH
(2021)
Article
Immunology
Carol G. Chitko-McKown, Stacy L. Bierman, Larry A. Kuehn, Gary L. Bennett, Keith D. DeDonder, Michael D. Apley, Gregory P. Harhay, Michael L. Clawson, Bradley J. White, Robert L. Larson, Sarah F. Capik, Brian V. Lubbers
Summary: The study aimed to develop a multiplex assay for bovine inflammatory cytokines IL-113, IL-6, and TNF alpha using the U-PLEX platform. Commercially available Do-It-Yourself ELISA kits containing polyclonal antibodies and specific recombinant bovine cytokine standards were purchased for each cytokine. The U-PLEX platform proved to be a viable means for developing custom analyte- and species-specific multiplex assays.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2021)
Article
Immunology
Kana Yokoyama, Hiroki Mitoma, Shotaro Kawano, Yusuke Yamauchi, Qiaolei Wang, Masahiro Ayano, Yasutaka Kimoto, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Summary: Systemic sclerosis is a multi-organ disease characterized by vascular damage, autoimmunity, and tissue fibrosis. Recent studies have shown that CEACAM-positive monocytes may be involved in tissue inflammation and fibrosis in early SSc. CEACAM-positive monocytes could potentially be biomarkers for detecting SSc patients with progressive ILD.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Aida Malek Mahdavi, Zeinab Javadivala
Summary: This study systematically reviewed the research on the influence of Coriandrum sativum L. on inflammatory mediators, finding that C. sativum consumption led to a considerable decrease in IL-1 beta, IL-6, and TNF-alpha levels. However, further investigations are needed to assess the impact of C. sativum on other inflammatory factors and the clinical consequences of inflammation-related diseases.
INFLAMMOPHARMACOLOGY
(2022)
Review
Immunology
Aida Malek Mahdavi, Zeinab Javadivala, Yeganeh Khalili, Majid Khalili
Summary: The aim of this systematic review was to gather research on the effect of quinoa on inflammatory parameters. The review included 20 animal and in vitro investigations and found that quinoa administration significantly decreased levels of IL-6, IL-1 beta, and TNF-alpha, indicating its potential in alleviating inflammatory factors.
INFLAMMOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Lianghui Cheng, Chunli Kong, Wenjia Wang, Andre Groeneveld, Arjen Nauta, Matthew R. Groves, Mensiena B. G. Kiewiet, Paul de Vos
Summary: Specific types of hMOs can attenuate TNF-alpha induced inflammation in fetal gut epithelial cells through TNFR1 in a structure-dependent fashion, suggesting the potential application of hMOs in the management of TNF-alpha dependent diseases.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Fahao Ma, Qian Wu, Mu Liu, Liren Zheng, Fengxia Tong, Zeyan Wang, Peng Wang, Yuanyuan Liu, Hefeng Cheng, Ying Dai, Zhaoke Zheng, Yuchen Fan, Baibiao Huang
Summary: Surface engineering plays a crucial role in enhancing the electrocatalytic performance of NiFe-PBA-F catalyst for oxygen evolution reaction (OER). The controlled removal of ligands through surface fluorination provides a pathway for maintaining the framework structure of NiFe-PBA, leading to the creation of more active sites for F-doped NiFeOOH. The lattice oxygen oxidation mechanism proposed for NiFe-PBA-F contributes to a better understanding of the reconstruction process and the OER mechanism.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Immunology
Yu Fang, Xiao-Dong Yuan, Hui-Hui Liu, Lin Xiang, La-Mei Chen, Yu-Chen Fan, Shuai Gao, Kai Wang
Summary: 5-Aza-2´-deoxycytidine treatment increased Tregs and Foxp3 expression in peripheral blood compared to control groups. HBV patients showed a pronounced increase in PD-1 expression, suggesting a potential effect of 5-Aza-2´-deoxycytidine on Treg differentiation in chronic HBV infection.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Lin Xiang, La-Mei Chen, Yu-Jia Zhai, Wei-Juan Sun, Jie-Ru Yang, Yu-Chen Fan, Kai Wang
Summary: In patients with HBV-associated HCC, the methylation level of SFRP2 was significantly higher compared to CHB patients and healthy controls, while mRNA level of SFRP2 was significantly lower in HCC patients. Moreover, the combination of SFRP2 methylation level and AFP showed a significantly improved diagnostic value in discriminating HBV-associated HCC from CHB, suggesting the potential of SFRP2 methylation level as a non-invasive biomarker for HCC diagnosis.
Article
Chemistry, Physical
Xiaolei Bao, Huiliang Li, Zeyan Wang, Fengxia Tong, Mu Liu, Zhaoke Zheng, Peng Wang, Hefeng Cheng, Yuanyuan Liu, Ying Dai, Yuchen Fan, Zhiyong Li, Baibiao Huang
Summary: In this study, a composite of TiO2 and Ti3C2 was developed to achieve efficient and selective oxidation of benzyl alcohol. The composite stabilizes active intermediates and enhances selectivity, leading to significantly improved conversion efficiency and selectivity compared to pristine TiO2.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2021)
Article
Immunology
Shuai Gao, Yu-Chen Fan, Li-Yan Han, Kai Wang
Summary: This study prospectively evaluated the predictive value of serum exosomal lncRNA NEAT1 for 90-day mortality of ACHBLF, showing that NEAT1 may be a better prognostic biomarker than MELD score. Higher levels of lncRNA NEAT1 were associated with poorer survival outcomes in ACHBLF patients.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yunqi Liu, Ximei Wang, Fuping Xu, Dengren Li, Huimin Yang, Nan Sun, Yu-Chen Fan, Xiangdong Yang
Summary: The study uncovered that the duration of HBV infection, Log(10) HBsAg, HBeAg-positive status, and dyslipidemia are risk factors for the development of chronic kidney disease during chronic HBV infection in the Chinese population.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Engineering, Environmental
Mu Liu, Xiaolei Bao, Fahao Ma, Minrui Wang, Liren Zheng, Zeyan Wang, Peng Wang, Yuanyuan Liu, Hefeng Cheng, Ying Dai, Yuchen Fan, Zhaoke Zheng, Baibiao Huang
Summary: The use of supercycle ALD technology has led to superior performance and stability for the TiO2@Cu system during CO2 reduction reaction, which was previously unattainable by traditional post-deposition TiO2 methods. This study has demonstrated a promising approach for enhancing the potential of ALD technique in the field of photocatalysis.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Cell Biology
Xiang-Fen Ji, Yu-Chen Fan, Fei Sun, Jing-Wei Wang, Kai Wang
Summary: Acute liver failure (ALF) is a deadly clinical disorder and has few effective treatments. This study revealed that Wnt5a/JNK signaling plays an important role in the development of ALF, and the Wnt5a antagonist Box5 has hepatoprotective effects in ALF.
Article
Public, Environmental & Occupational Health
He Wang, Yu Qian, Jing-Wen Wang, Yu Fang, Yu-Chen Fan, Hui-Hui Liu, Kai Wang
Summary: The methylation status of the T beta 4 promoter is associated with the severity of ACHBLF. Glucocorticoid treatment can reduce the methylation frequency and improve the treatment response and survival of patients with ACHBLF.
INTERNATIONAL HEALTH
(2023)
Article
Gastroenterology & Hepatology
Hui-Hui Liu, Ju Wang, Ying Zhang, Yu-Chen Fan, Kai Wang
Summary: This study reveals that increased expression of Ran in hepatocellular carcinoma (HCC) is associated with worse overall survival and immune infiltrates. Ran could serve as a biomarker for predicting the prognosis of HCC patients.
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2022)
Article
Oncology
Jie-Ru Yang, Ju Wang, Hai-Ming Li, Shuai Gao, Yu-Chen Fan, Kai Wang
Summary: The study found that the IL-6 promoter methylation level is significantly lower in patients with HBV-associated hepatocellular carcinoma, and it is independently associated with the development of liver cancer. The combined use of IL-6 methylation level and AFP can improve the diagnostic accuracy of liver cancer.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Yu Shi, Yuchen Fan, Tao Chen
FRONTIERS IN MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Xueqin Gong, Yujia Zhang, Yayang Xu, Guangyao Zhai, Xiaolei Liu, Xiaolei Bao, Zeyan Wang, Yuanyuan Liu, Peng Wang, Hefeng Cheng, Yuchen Fan, Ying Dai, Zhaoke Zheng, Baibiao Huang
Summary: This study introduces g-C3N4/Ag hybrids as a promising catalyst for CO2 cycloaddition. The coupling of a semiconductor into the plasmonic system enhances the activity of the reaction. The mechanism involves CO2 chemisorption by ACN and the activation of propylene oxide by photo-generated electrons from ACN transferring to Ag. Experimental evidence confirms the importance of plasmon excitation.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Medicine, Research & Experimental
Huihui Liu, Hui Lyu, Xuemei Jiang, Li Wang, Haiming Li, Xuefei Wei, Linlin Li, Jinyu Zhu, Yuchen Fan, Kai Wang
Summary: The study aimed to assess the prognostic efficacy of superoxide dismutase 2 (SOD2) for 90-day mortality in patients with hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). The results showed that SOD2 expression levels were significantly decreased in HBV-ACLF patients and were negatively correlated with serum total bilirubin and model for end-stage liver disease scores. SOD2 exhibited a higher predictive value for 90-day mortality than the MELD score, suggesting its potential as a promising predictor for HBV-ACLF patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Shuai Gao, Li-Yan Han, Yu-Chen Fan, Kai Wang
Summary: This study aimed to establish a noninvasive model for predicting the 90-day mortality in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) who received glucocorticoid therapy. The HITAS score, based on hepatic encephalopathy grade, INR, total bilirubin, age, and SIRS status, showed better predictive value for 90-day mortality of HBV-ACLF compared to other scoring systems. The HITAS score can help identify HBV-ACLF patients with favorable responses to glucocorticoid treatment.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)