Targeting disease through novel pathways of apoptosis and autophagy

Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL

(2016) Yan Chen Shang et al.   Aging-US

Targeting Conserved Pathways: Mitochondrial Dysfunction and Beyond

(2013) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

Microarray expression analysis of genes and pathways involved in growth plate cartilage injury responses and bony repair

(2012) Carmen E. Macsai et al.   BONE

Mammalian target of rapamycin signaling in diabetic cardiovascular disease

(2012) Zhao Chong et al.   Cardiovascular Diabetology

Wnt1 Inducible Signaling Pathway Protein 1 (WISP1) Blocks Neurodegeneration through Phosphoinositide 3 Kinase/Akt1 and Apoptotic Mitochondrial Signaling Involving Bad, Bax, Bim, and Bcl-xL

(2012) Shaohui Wang et al.   CURRENT NEUROVASCULAR RESEARCH

Mapping Autophagy on to Your Metabolic Radar

(2012) E. Yamada et al.   DIABETES

SIRT1: new avenues of discovery for disorders of oxidative stress

(2012) Zhao Zhong Chong et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies HarboringPIK3CAMutations

(2012) Filip Janku et al.   JOURNAL OF CLINICAL ONCOLOGY

GLP1-derived nonapeptide GLP1(28–36)amide protects pancreatic β-cells from glucolipotoxicity

(2012) Zhengu Liu et al.   JOURNAL OF ENDOCRINOLOGY

Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/ -Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair

(2012) F. L'Episcopo et al.   JOURNAL OF NEUROSCIENCE

Autophagy induced by resveratrol prevents human prion protein-mediated neurotoxicity

(2012) Jae-Kyo Jeong et al.   NEUROSCIENCE RESEARCH

Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function

(2012) N. Jaber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity

(2012) Emmanouil Fokas et al.   Radiation Oncology

Cardiovascular Disease and mTOR Signaling

(2012) Zhao Zhong Chong et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation

(2012) Vojo Deretic et al.   TRENDS IN CELL BIOLOGY

Neuroprotective cytokines repress PUMA induction in the 1-methyl-4-phenylpyridinium (MPP+) model of Parkinson’s disease

(2011) Yeon-Hee Kook et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Single bout of running exercise changes LC3-II expression in rat cardiac muscle

(2011) Yuji Ogura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial longevity pathways

(2011) M.H. Vendelbo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The functions of mTOR in ischemic diseases

(2011) Seo-Kyoung Hwang et al.   BMB Reports

Erufosine simultaneously induces apoptosis and autophagy by modulating the Akt–mTOR signaling pathway in oral squamous cell carcinoma

(2011) Vaishali Kapoor et al.   CANCER LETTERS

FoxO3 induces reversible cardiac atrophy and autophagy in a transgenic mouse model

(2011) Tobias G. Schips et al.   CARDIOVASCULAR RESEARCH

GABARAPL1 Negatively Regulates Wnt/β-catenin Signaling by Mediating Dvl2 Degradation through the Autophagy Pathway

(2011) Yanquan Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Synthesis and Comparison of Antioxidant Properties of Indole-Based Melatonin Analogue Indole Amino Acid Derivatives

(2011) Sibel Suzen et al.   Chemical Biology & Drug Design

Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimers Disease

(2011) D. F.F. Silva et al.   Current Alzheimer Research

The Hypomethylation Agent Bisdemethoxycurcumin Acts on the WIF-1 Promoter, Inhibits the Canonical Wnt Pathway and Induces Apoptosis in Human Non-Small-Cell Lung Cancer

(2011) Y.-L. Liu et al.   CURRENT CANCER DRUG TARGETS

Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia

(2011) Yan Chen Shang et al.   CURRENT NEUROVASCULAR RESEARCH

EPO Relies upon Novel Signaling of Wnt1 that Requires Akt1, FoxO3a,GSK-3β, and β-Catenin to Foster Vascular Integrity during Experimental Diabetes

(2011) Zhao Zhong Chong et al.   CURRENT NEUROVASCULAR RESEARCH

Knockdown of RON Inhibits AP-1 Activity and Induces Apoptosis and Cell Cycle Arrest Through the Modulation of Akt/FoxO Signaling in Human Colorectal Cancer Cells

(2011) Cho-Yun Chung et al.   DIGESTIVE DISEASES AND SCIENCES

Increased Oxidative DNA Damage in Lean Normoglycemic Offspring of Type 2 Diabetic Patients

(2011) A. Zengi et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

A novel cardioprotective p38-MAPK/mTOR pathway

(2011) Gonzalo Hernández et al.   EXPERIMENTAL CELL RESEARCH

Emodin-induced microglial apoptosis is associated with TRB3 induction

(2011) Xueping Zhou et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Mechanical Stretch Induces Epithelial-Mesenchymal Transition in Alveolar Epithelia via Hyaluronan Activation of Innate Immunity

(2011) Rebecca L. Heise et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erythropoietin mediated bone formation is regulated by mTOR signaling

(2011) Jinkoo Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation

(2011) Venkatapuram Seenu Reddy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

(2011) Rui-Hong Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy

(2011) Prakashsrinivasan Shanmugam et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Momordica charantia (bitter melon) attenuates high-fat diet-associated oxidative stress and neuroinflammation

(2011) Pratibha V Nerurkar et al.   Journal of Neuroinflammation

Severe Global Cerebral Ischemia-Induced Programmed Necrosis of Hippocampal CA1 Neurons in Rat Is Prevented by 3-Methyladenine: A Widely Used Inhibitor of Autophagy

(2011) Jin-Ye Wang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Silymarin protects neurons from oxidative stress associated damages in focal cerebral ischemia: A behavioral, biochemical and immunohistological study in Wistar rats

(2011) Syed Shadab Raza et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Nicotinamide Attenuates the Decrease of Astrocytic Phosphoprotein PEA-15 in Focal Cerebral Ischemic Injury

(2011) Phil-Ok KOH   JOURNAL OF VETERINARY MEDICAL SCIENCE

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

Forced treadmill exercise prevents oxidative stress and memory deficits following chronic cerebral hypoperfusion in the rat

(2011) Fernanda Cechetti et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Phospho-Rb Mediating Cell Cycle Reentry Induces Early Apoptosis Following Oxygen–Glucose Deprivation in Rat Cortical Neurons

(2011) Ying Yu et al.   NEUROCHEMICAL RESEARCH

Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders

(2011) Zhao Zhong Chong et al.   Oxidative Medicine and Cellular Longevity

Therapeutic benefits of the group B3 vitamin nicotinamide in mice with lethal endotoxemia and polymicrobial sepsis

(2011) Hongmei Yuan et al.   PHARMACOLOGICAL RESEARCH

Nicotinamide Inhibits Alkylating Agent-Induced Apoptotic Neurodegeneration in the Developing Rat Brain

(2011) Najeeb Ullah et al.   PLoS One

Differential Expression of Wnts after Spinal Cord Contusion Injury in Adult Rats

(2011) Carmen María Fernández-Martos et al.   PLoS One

Exposure to16O-Particle Radiation Causes Aging-Like Decrements in Rats through Increased Oxidative Stress, Inflammation and Loss of Autophagy

(2011) Shibu M. Poulose et al.   RADIATION RESEARCH

Genome-Wide Analysis of a Wnt1-Regulated Transcriptional Network Implicates Neurodegenerative Pathways

(2011) E. M. Wexler et al.   Science Signaling

Vascular Incompetence in Dialysis Patients-Protein-Bound Uremic Toxins and Endothelial Dysfunction

(2011) Noémie Jourde-Chiche et al.   SEMINARS IN DIALYSIS

The Wnt/beta-catenin pathway is activated during advanced arterial aging in humans

(2010) Alexandre Marchand et al.   AGING CELL

Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia

(2010) Ai-Ping Qin et al.   Autophagy

Dasatinib induces autophagic cell death in human ovarian cancer

(2010) Xiao-Feng Le et al.   CANCER

Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1

(2010) Emmani B.M. Nascimento et al.   CELLULAR SIGNALLING

Wnt1, FoxO3a, and NF-κB oversee microglial integrity and activation during oxidant stress

(2010) Yan Chen Shang et al.   CELLULAR SIGNALLING

WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte death

(2010) Balachandar Venkatesan et al.   CELLULAR SIGNALLING

Early Apoptotic Vascular Signaling is Determined by Sirt1 Through Nuclear Shuttling, Forkhead Trafficking, Bad, and Mitochondrial Caspase Activation

(2010) Jinling Hou et al.   CURRENT NEUROVASCULAR RESEARCH

The inhibitor of phagocytosis, O-phospho-l-serine, suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina

(2010) Travis J. Bailey et al.   EXPERIMENTAL EYE RESEARCH

Phosphoinositide 3-Kinase Signaling Mediates β-Catenin Activation in Intestinal Epithelial Stem and Progenitor Cells in Colitis

(2010) Goo Lee et al.   GASTROENTEROLOGY

Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure

(2010) Masaya Tanno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cells through inhibition of Wnt/β-catenin signaling

(2010) Jin-Ran Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

(2010) Denghong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Novel Avenues of Drug Discovery and Biomarkers for Diabetes Mellitus

(2010) Kenneth Maiese et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy

(2010) Chutikorn Nopparat et al.   JOURNAL OF PINEAL RESEARCH

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

(2010) Long Chen et al.   LABORATORY INVESTIGATION

FOXO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling

(2010) Jinling Hou et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Activation of autophagy during cell death requires the engulfment receptor Draper

(2010) Christina K. McPhee et al.   NATURE

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

(2010) F. L'Episcopo et al.   NEUROBIOLOGY OF DISEASE

Wnt1 Neuroprotection Translates into Improved Neurological Function during Oxidant Stress and Cerebral Ischemia ThroughAKT1and Mitochondrial Apoptotic Pathways

(2010) Zhao Zhong Chong et al.   Oxidative Medicine and Cellular Longevity

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cells

(2010) Nathalie Carayol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/ -Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth

(2009) N. Baryawno et al.   CANCER RESEARCH

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

(2009) S Luo et al.   CELL DEATH AND DIFFERENTIATION

The Forkhead Transcription Factor FOXO3a Controls Microglial Inflammatory Activation and Eventual Apoptotic Injury through Caspase 3

(2009) Yan Shang et al.   CURRENT NEUROVASCULAR RESEARCH

FoxO3a Governs Early Microglial Proliferation and Employs Mitochondrial Depolarization with Caspase 3, 8, and 9 Cleavage During Oxidant Induced Apoptosis

(2009) Yan Shang et al.   CURRENT NEUROVASCULAR RESEARCH

The role of local protein synthesis and degradation in axon regeneration

(2009) Laura F. Gumy et al.   EXPERIMENTAL NEUROLOGY

mTOR/S6 Kinase Pathway Contributes to Astrocyte Survival during Ischemia

(2009) María Dolores Pastor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endostatin induces autophagy in endothelial cells by modulating Beclin 1 and β-catenin levels

(2009) Tri Minh Bui Nguyen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death

(2009) Kyou-Chan Choi et al.   JOURNAL OF NEUROCHEMISTRY

Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in  -Synuclein Models of Parkinson's and Lewy Body Diseases

(2009) B. Spencer et al.   JOURNAL OF NEUROSCIENCE

Autophagy-mediated stress response in motor neuron after transient ischemia in rabbits

(2009) Hironori Baba et al.   JOURNAL OF VASCULAR SURGERY

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

(2009) Kiran Bhaskar et al.   Molecular Neurodegeneration

The Vitamin Nicotinamide: Translating Nutrition into Clinical Care

(2009) Kenneth Maiese et al.   MOLECULES

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy

(2009) Maria Xilouri et al.   PLoS One

Effect of rapamycin therapy on coronary artery physiology early after cardiac transplantation

(2008) Seema S. Sinha et al.   AMERICAN HEART JOURNAL

Caspase-3 Is Enriched in Postsynaptic Densities and Increased in Alzheimer's Disease

(2008) Natalia Louneva et al.   AMERICAN JOURNAL OF PATHOLOGY

Rogue proliferation versus restorative protection: Where do we draw the line for Wnt and Forkhead signaling?

(2008) Kenneth Maiese et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

β-Catenin Levels Influence Rapid Mechanical Responses in Osteoblasts

(2008) Natasha Case et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Life Span Extension and Neuronal Cell Protection byDrosophilaNicotinamidase

(2008) Vitaly Balan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Wnt signaling pathway: Aging gracefully as a protectionist?

(2008) Kenneth Maiese et al.   PHARMACOLOGY & THERAPEUTICS