mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation
Authors
Keywords
-
Journal
ONCOGENE
Volume 35, Issue 2, Pages 148-157
Publisher
Springer Nature
Online
2015-04-14
DOI
10.1038/onc.2015.79
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The eIF4E/eIF4G Interaction Inhibitor 4EGI-1 Augments TRAIL-Mediated Apoptosis through c-FLIP Down-regulation and DR5 Induction Independent of Inhibition of Cap-Dependent Protein Translation
- (2015) Songqing Fan et al. NEOPLASIA
- Where is mTOR and what is it doing there?
- (2014) Charles Betz et al. JOURNAL OF CELL BIOLOGY
- A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
- (2014) B. C. Grabiner et al. Cancer Discovery
- Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib
- (2014) N. Wagle et al. Cancer Discovery
- Inhibition of S6 kinase suppresses the apoptotic effect of eIF4E ablation by inducing TGF-β-dependent G1 cell cycle arrest
- (2013) Paige Yellen et al. CANCER LETTERS
- eRapa Restores a Normal Life Span in a FAP Mouse Model
- (2013) P. Hasty et al. Cancer Prevention Research
- Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance
- (2013) Agnieszka Kaczmarek et al. IMMUNITY
- Inactivation of the mTORC1-Eukaryotic Translation Initiation Factor 4E Pathway Alters Stress Granule Formation
- (2013) M.-J. Fournier et al. MOLECULAR AND CELLULAR BIOLOGY
- Hsp90 Inhibitors Promote p53-Dependent Apoptosis through PUMA and Bax
- (2013) Kan He et al. MOLECULAR CANCER THERAPEUTICS
- Crizotinib Induces PUMA-Dependent Apoptosis in Colon Cancer Cells
- (2013) X. Zheng et al. MOLECULAR CANCER THERAPEUTICS
- Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors
- (2013) G S Ducker et al. ONCOGENE
- Cancer Genome Landscapes
- (2013) B. Vogelstein et al. SCIENCE
- The cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction
- (2012) G Descamps et al. BRITISH JOURNAL OF CANCER
- Cancer statistics, 2012
- (2012) Rebecca Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies
- (2012) T. Alain et al. CANCER RESEARCH
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors
- (2012) Yanjie Zhang et al. CELL CYCLE
- The promise of mTOR inhibitors in the treatment of colorectal cancer
- (2012) Dae-Dong Kim et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- The PP242 Mammalian Target of Rapamycin (mTOR) Inhibitor Activates Extracellular Signal-regulated Kinase (ERK) in Multiple Myeloma Cells via a Target of Rapamycin Complex 1 (TORC1)/ Eukaryotic Translation Initiation Factor 4E (eIF-4E)/RAF Pathway and Activation Is a Mechanism of Resistance
- (2012) Bao Hoang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A unifying model for mTORC1-mediated regulation of mRNA translation
- (2012) Carson C. Thoreen et al. NATURE
- Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth
- (2012) C Dudgeon et al. ONCOGENE
- The Multi-Targeted Kinase Inhibitor Sunitinib Induces Apoptosis in Colon Cancer Cells via PUMA
- (2012) Jing Sun et al. PLoS One
- mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways
- (2011) P. Gulhati et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Smac Modulates Chemosensitivity in Head and Neck Cancer Cells through the Mitochondrial Apoptotic Pathway
- (2011) Q. Sun et al. CLINICAL CANCER RESEARCH
- Mitochondrial signaling in cell death via the Bcl-2 family
- (2010) Brian Leibowitz et al. CANCER BIOLOGY & THERAPY
- 4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors
- (2010) Qing-Bai She et al. CANCER CELL
- The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis
- (2010) Y J Kang et al. CELL DEATH AND DIFFERENTIATION
- PUMA Induction by FoxO3a Mediates the Anticancer Activities of the Broad-Range Kinase Inhibitor UCN-01
- (2010) C. Dudgeon et al. MOLECULAR CANCER THERAPEUTICS
- mTOR Signaling Pathway Is a Target for the Treatment of Colorectal Cancer
- (2009) Yan-Jie Zhang et al. ANNALS OF SURGICAL ONCOLOGY
- Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
- (2009) Nahum Sonenberg et al. CELL
- PUMA is directly activated by NF-κB and contributes to TNF-α-induced apoptosis
- (2009) P Wang et al. CELL DEATH AND DIFFERENTIATION
- Targeted Inhibition of Mammalian Target of Rapamycin Signaling Inhibits Tumorigenesis of Colorectal Cancer
- (2009) P. Gulhati et al. CLINICAL CANCER RESEARCH
- Targeting the extrinsic apoptosis pathway in cancer
- (2008) Avi Ashkenazi CYTOKINE & GROWTH FACTOR REVIEWS
- Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis
- (2008) Umut Ozcan et al. MOLECULAR CELL
- Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in Apc 716 mice
- (2008) T. Fujishita et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now