Immune Cell Regulatory Pathways Unexplored as Host-Directed Therapeutic Targets forMycobacterium tuberculosis: An Opportunity to Apply Precision Medicine Innovations to Infectious Diseases

Atorvastatin protects cardiomyocytes from oxidative stress by inhibiting LOX-1 expression and cardiomyocyte apoptosis

(2015) Lei Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Endoplasmic Reticulum Stress in Immunity

(2015) Sarah E. Bettigole et al.   Annual Review of Immunology

Tauroursodeoxycholic acid prevents stress induced aggregation of proteins in vitro and promotes PERK activation in HepG2 cells

(2015) Amina R. Gani et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Activation of AMPA receptor promotes TNF-α release via the ROS-cSrc-NFκB signaling cascade in RAW264.7 macrophages

(2015) Xiu-Li Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

(2015) James Ozanne et al.   BIOCHEMICAL JOURNAL

Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies

(2015) Wenguang Chang et al.   Biochemistry and Cell Biology

Antiasthmatic Effects of Resveratrol in Ovalbumin-Induced Asthma Model Mice Involved in the Upregulation of PTEN

(2015) Guo Chen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Wnt/β-Catenin signaling reduces Bacillus Calmette-Guerin-induced macrophage necrosis through a ROS -mediated PARP/AIF-dependent pathway

(2015) Xiaoling Wu et al.   BMC IMMUNOLOGY

Phase 2 study of MK-2206, an allosteric inhibitor of AKT, as second-line therapy for advanced gastric and gastroesophageal junction cancer: A SWOG cooperative group trial (S1005)

(2015) Ramesh K. Ramanathan et al.   CANCER

PTEN inhibits macrophage polarization from M1 to M2 through CCL2 and VEGF-A reduction and NHERF-1 synergism

(2015) Ning Li et al.   CANCER BIOLOGY & THERAPY

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

Targeting PI3K/AKT/mTOR network for treatment of leukemia

(2015) Jessika Bertacchini et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Wnt1 Positively Regulates CD36 Expression via TCF4 and PPAR-γ in Macrophages

(2015) Shuai Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Quest for Correlates of Protection against Tuberculosis

(2015) Kamlesh Bhatt et al.   Clinical and Vaccine Immunology

Development of Small Molecules Targeting the Wnt Signaling Pathway in Cancer Stem Cells for the Treatment of Colorectal Cancer

(2015) Lele Song et al.   Clinical Colorectal Cancer

Phase I Study of S-Trans, Trans-Farnesylthiosalicylic Acid (Salirasib), a Novel Oral RAS Inhibitor in Patients With Refractory Hematologic Malignancies

(2015) Talha Badar et al.   Clinical Lymphoma Myeloma & Leukemia

Regression of Oxidative Stress by Targeting eNOS and Nrf2/ARE Signaling: A Guided Drug Target for Cardiovascular Diseases

(2015) Tharmarajan Ramprasath et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Perampanel in the treatment of partial seizures: Time to onset and duration of most common adverse events from pooled Phase III and extension studies

(2015) David Ko et al.   EPILEPSY & BEHAVIOR

Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages

(2015) James P. Barrett et al.   EXPERIMENTAL CELL RESEARCH

Clinical efficacy of mTOR inhibitors in solid tumors: a systematic review

(2015) Zebo Huang et al.   Future Oncology

TLR4 is a critical regulator of angiotensin II-induced vascular remodeling: the roles of extracellular SOD and NADPH oxidase

(2015) Tadaaki Nakashima et al.   HYPERTENSION RESEARCH

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

(2015) Julianna Blagih et al.   IMMUNITY

Sensing ofMycobacterium tuberculosisand consequences to both host and bacillus

(2015) Chelsea E. Stamm et al.   IMMUNOLOGICAL REVIEWS

Toll-Like Receptor 2-Dependent Extracellular Signal-Regulated Kinase Signaling in Mycobacterium tuberculosis-Infected Macrophages Drives Anti-Inflammatory Responses and Inhibits Th1 Polarization of Responding T Cells

(2015) Edward T. Richardson et al.   INFECTION AND IMMUNITY

Development of autophagy inducers in clinical medicine

(2015) Beth Levine et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes

(2015) Zhiyong Zhang et al.   JOURNAL OF IMMUNOLOGY

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors

(2015) Curt D. Haffner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adjunctive vitamin D for treatment of active tuberculosis in India: a randomised, double-blind, placebo-controlled trial

(2015) Peter Daley et al.   LANCET INFECTIOUS DISEASES

PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

(2015) Sara Martire et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells

(2015) Ozlem Kulak et al.   MOLECULAR AND CELLULAR BIOLOGY

Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance

(2015) Peter Bai   MOLECULAR CELL

Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy

(2015) Rosa Barreira da Silva et al.   NATURE IMMUNOLOGY

Taming the inflammasome

(2015) Maayan Levy et al.   NATURE MEDICINE

The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD

(2015) Jim Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

A New Initiative on Precision Medicine

(2015) Francis S. Collins et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bisbibenzyls, novel proteasome inhibitors, suppress androgen receptor transcriptional activity and expression accompanied by activation of autophagy in prostate cancer LNCaP cells

(2015) Zhongyi Hu et al.   PHARMACEUTICAL BIOLOGY

Telmisartan decreases inflammation by modulating TNF-α, IL-10, and RANK/RANKL in a rat model of ulcerative colitis

(2015) Gerlane C.B. Guerra et al.   Pharmacological Reports

Targeting the Wnt pathway in human cancers: Therapeutic targeting with a focus on OMP-54F28

(2015) Phuong N. Le et al.   PHARMACOLOGY & THERAPEUTICS

Effects of Silybum marianum (L.) Gaertn. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: A randomized, triple-blind, placebo-controlled clinical trial

(2015) Soraiya Ebrahimpour koujan et al.   PHYTOMEDICINE

Dendritic cell SIRT1–HIF1α axis programs the differentiation of CD4+T cells through IL-12 and TGF-β1

(2015) Guangwei Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery

(2015) Meenal Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T lymphocyte regulation by mevalonate metabolism

(2015) Martin Thurnher et al.   Science Signaling

Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models

(2015) Sevdican Üstün et al.   TRANSPLANT IMMUNOLOGY

Current treatment strategies for inhibiting mTOR in cancer

(2015) Francesca Chiarini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Angiotensins as therapeutic targets beyond heart disease

(2015) Danielle Gomes Passos-Silva et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

FDA-approved small-molecule kinase inhibitors

(2015) Peng Wu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Beyond adjuvants: Immunomodulation strategies to enhance T cell immunity

(2015) Alice O. Kamphorst et al.   VACCINE

The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control

(2015) Sravanth K. Hindupur et al.   Cold Spring Harbor Perspectives in Biology

Ursolic acid inhibits the development of nonalcoholic fatty liver disease by attenuating endoplasmic reticulum stress

(2015) Jian-Shuang Li et al.   Food & Function

New mechanisms of metformin action: Focusing on mitochondria and the gut

(2015) Kyu Yeon Hur et al.   Journal of Diabetes Investigation

The tuberculosis necrotizing toxin kills macrophages by hydrolyzing NAD

(2015) Jim Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia

(2015) Alice Cani et al.   Oncotarget

p53-induced autophagy and senescence

(2015) Xinbing Sui et al.   Oncotarget

Low Doses of Imatinib Induce Myelopoiesis and Enhance Host Anti-microbial Immunity

(2015) Ruth J. Napier et al.   PLoS Pathogens

Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis

(2015) Diana Moreira et al.   PLoS Pathogens

T lymphocyte regulation by mevalonate metabolism

(2015) Martin Thurnher et al.   Science Signaling

A review of the efficacy and safety of extended-release topiramate in the adjunctive treatment for refractory partial-onset seizures

(2015) Steve S. Chung   Therapeutic Advances in Neurological Disorders

Resveratrol Targets in Inflammation

(2015) Hiroyasu Inoue et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis

(2015) Mamoudou Maiga et al.   EBioMedicine

Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control

(2015) Filipa Cardoso et al.   PLoS One

The Role of High Mobility Group Box 1 Protein (HMGB1) in the Immunopathology of Experimental Pulmonary Tuberculosis

(2015) Rogelio Hernández-Pando et al.   PLoS One

Mycobacterium tuberculosis 38-kDa antigen induces endoplasmic reticulum stress-mediated apoptosis via toll-like receptor 2/4

(2014) Yun-Ji Lim et al.   APOPTOSIS

The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy

(2014) Chul-Su Yang et al.   Autophagy

The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma

(2014) A. Spencer et al.   BLOOD

Mammalian target of Rapamycin inhibition and mycobacterial survival are uncoupled in murine macrophages

(2014) Alfred J Zullo et al.   BMC BIOCHEMISTRY

DPP-4 Inhibitors Repress NLRP3 Inflammasome and Interleukin-1beta via GLP-1 Receptor in Macrophages Through Protein Kinase C Pathway

(2014) Yao Dai et al.   CARDIOVASCULAR DRUGS AND THERAPY

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration

(2014) Ying Zhang et al.   CELL AND TISSUE RESEARCH

A unique role for p53 in the regulation of M2 macrophage polarization

(2014) L Li et al.   CELL DEATH AND DIFFERENTIATION

Metformin: From Mechanisms of Action to Therapies

(2014) Marc Foretz et al.   Cell Metabolism

AMPK—Sensing Energy while Talking to Other Signaling Pathways

(2014) D. Grahame Hardie   Cell Metabolism

Oxidative Stress, Redox Signaling and Cancer Chemoresistance: Putting Together the Pieces of the Puzzle

(2014) Vanessa Victorino et al.   CURRENT MEDICINAL CHEMISTRY

Diabetes and immunity to tuberculosis

(2014) Nuria Martinez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sirtuin-dependent epigenetic regulation in the maintenance of genome integrity

(2014) Laia Bosch-Presegué et al.   FEBS Journal

Sirtuin inhibitors as anticancer agents

(2014) Jing Hu et al.   Future Medicinal Chemistry

Attenuation of the progression of adjuvant-induced arthritis by 3-aminobenzamide treatment

(2014) Sheikh Fayaz Ahmad et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Caspase-Dependent Pathway Is Involved in Wnt/β-Catenin Signaling Promoted Apoptosis in Bacillus Calmette-Guerin Infected RAW264.7 Macrophages

(2014) Xiaoling Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Simvastatin increases the in vivo activity of the first-line tuberculosis regimen

(2014) C. Skerry et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Sequential Actions of SIRT1-RELB-SIRT3 Coordinate Nuclear-Mitochondrial Communication during Immunometabolic Adaptation to Acute Inflammation and Sepsis

(2014) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome

(2014) Vidula T. Vachharajani et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Simvastatin interacts synergistically with tipifarnib to induce apoptosis in leukemia cells through the disruption of RAS membrane localization and ERK pathway inhibition

(2014) Tamer A. Ahmed et al.   LEUKEMIA RESEARCH

Metformin enhances nitric oxide production and diminishes Rho kinase activity in rats with hyperlipidemia

(2014) Yan Liu et al.   Lipids in Health and Disease

The Wnt/β-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria

(2014) Octavio Silva-García et al.   MEDIATORS OF INFLAMMATION

Mycobacterium bovis BCG promotes tumor cell survival from tumor necrosis factor-α-induced apoptosis

(2014) Sahana Holla et al.   Molecular Cancer

Interception of host angiogenic signalling limits mycobacterial growth

(2014) Stefan H. Oehlers et al.   NATURE

An update on PARP inhibitors—moving to the adjuvant setting

(2014) Amir Sonnenblick et al.   Nature Reviews Clinical Oncology

Targeting RAS–ERK signalling in cancer: promises and challenges

(2014) Ahmed A. Samatar et al.   NATURE REVIEWS DRUG DISCOVERY

PARP-1 activation causes neuronal death in the hippocampal CA1 region by increasing the expression of Ca2+-permeable AMPA receptors

(2014) E. Gerace et al.   NEUROBIOLOGY OF DISEASE

Phase II/III trial of a pre-transplant farnesyl transferase inhibitor in juvenile myelomonocytic leukemia: A report from the Children's Oncology Group

(2014) Elliot Stieglitz et al.   PEDIATRIC BLOOD & CANCER

Selective Inhibition of PI3K/Akt/mTOR Signaling Pathway Regulates Autophagy of Macrophage and Vulnerability of Atherosclerotic Plaque

(2014) Chungang Zhai et al.   PLoS One

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells

(2014) T. B. Sundberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Docosahexaenoic acid decreases TNF-α-induced lectin-like oxidized low-density lipoprotein receptor-1 expression in THP-1 cells

(2014) Kazuo Yamagata et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Metformin as adjunct antituberculosis therapy

(2014) A. Singhal et al.   Science Translational Medicine

Advances in kinase targeting: current clinical use and clinical trials

(2014) Mathias Rask-Andersen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Host-pathogen interactions in tuberculosis patients with type 2 diabetes mellitus

(2014) Blanca I. Restrepo et al.   TUBERCULOSIS

Sirtuins Are Evolutionarily Conserved Viral Restriction Factors

(2014) Emre Koyuncu et al.   mBio

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

Rapid Evolution of PARP Genes Suggests a Broad Role for ADP-Ribosylation in Host-Virus Conflicts

(2014) Matthew D. Daugherty et al.   PLoS Genetics

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth

(2014) Sarah A. Stanley et al.   PLoS Pathogens

Interaction of vitamin D with membrane-based signaling pathways

(2014) María Jesús Larriba et al.   Frontiers in Physiology

DPP-4 inhibitors repress foam cell formation by inhibiting scavenger receptors through protein kinase C pathway

(2013) Yao Dai et al.   ACTA DIABETOLOGICA

Induction of autophagy by Imatinib sequesters Bcr-Abl in autophagosomes and down-regulates Bcr-Abl protein

(2013) Baukje M. Elzinga et al.   AMERICAN JOURNAL OF HEMATOLOGY

Vitamin D Biology Revealed Through the Study of Knockout and Transgenic Mouse Models

(2013) Sylvia Christakos et al.   Annual Review of Nutrition

Rho/Rho-Associated Coiled-Coil Forming Kinase Pathway as Therapeutic Targets for Statins in Atherosclerosis

(2013) Naoki Sawada et al.   ANTIOXIDANTS & REDOX SIGNALING

Fasudil inhibits ER stress-induced VCAM-1 expression by modulating unfolded protein response in endothelial cells

(2013) Daiji Kawanami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IκB kinase ɛ (IKKɛ): A therapeutic target in inflammation and cancer

(2013) Kelly Verhelst et al.   BIOCHEMICAL PHARMACOLOGY

Anti-leprosy drug clofazimine inhibits growth of triple-negative breast cancer cells via inhibition of canonical Wnt signaling

(2013) A.V. Koval et al.   BIOCHEMICAL PHARMACOLOGY

Enhancement of Autophagy by Simvastatin through Inhibition of Rac1-mTOR Signaling Pathway in Coronary Arterial Myocytes

(2013) Yu-Miao Wei et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Therapeutic effect of farnesylthiosalicylic acid on adjuvant-induced arthritis through suppressed release of inflammatory cytokines

(2013) E. Aizman et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

NAD+metabolism: A therapeutic target for age-related metabolic disease

(2013) Laurent Mouchiroud et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Autophagy as an immune effector against tuberculosis

(2013) Steven B Bradfute et al.   CURRENT OPINION IN MICROBIOLOGY

The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing

(2013) S. Imai et al.   DIABETES OBESITY & METABOLISM

Advances in the development of Rho-associated protein kinase (ROCK) inhibitors

(2013) Peichen Pan et al.   DRUG DISCOVERY TODAY

AMPKα1: A glucose sensor that controls CD8 T-cell memory

(2013) Julia Rolf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endoplasmic Reticulum Stress Promotes Macrophage-derived Foam Cell Formation by Up-regulating Cluster of Differentiation 36 (CD36) Expression

(2013) Shutong Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho Kinases in Cardiovascular Physiology and Pathophysiology

(2013) Jianjian Shi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Sirtuins' modulation of autophagy

(2013) Fanny Ng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Essential Requirements of Zoledronate-Induced Cytokine and    T Cell Proliferative Responses

(2013) O. Nussbaumer et al.   JOURNAL OF IMMUNOLOGY

Wnt6 Is Expressed in Granulomatous Lesions of Mycobacterium tuberculosis-Infected Mice and Is Involved in Macrophage Differentiation and Proliferation

(2013) K. Schaale et al.   JOURNAL OF IMMUNOLOGY

Interferon-Stimulated Poly(ADP-Ribose) Polymerases Are Potent Inhibitors of Cellular Translation and Virus Replication

(2013) S. Atasheva et al.   JOURNAL OF VIROLOGY

Perifosine treatment in chronic lymphocytic leukemia: results of a phase II clinical trial andin vitrostudies

(2013) Daphne R. Friedman et al.   LEUKEMIA & LYMPHOMA

Phase I clinical, pharmacokinetic, and pharmacodynamic study of the Akt-inhibitor triciribine phosphate monohydrate in patients with advanced hematologic malignancies

(2013) Deepa Sampath et al.   LEUKEMIA RESEARCH

Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes

(2013) Carles Cantó et al.   MOLECULAR ASPECTS OF MEDICINE

Synergistic induction of human cathelicidin antimicrobial peptide gene expression by vitamin D and stilbenoids

(2013) Chunxiao Guo et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mycoplasma fermentans Inhibits the Activity of Cellular DNA Topoisomerase I by Activation of PARP1 and Alters the Efficacy of Its Anti-Cancer Inhibitor

(2013) Reuven Afriat et al.   PLoS One

PARP-1 Controls Immunosuppressive Function of Regulatory T Cells by Destabilizing Foxp3

(2013) Pin Zhang et al.   PLoS One

SMAD-PI3K-Akt-mTOR Pathway Mediates BMP-7 Polarization of Monocytes into M2 Macrophages

(2013) Crystal Rocher et al.   PLoS One

AMPK 2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6

(2013) B. Gongol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection

(2013) H. A. Eskandarian et al.   SCIENCE

Targeting the NF-κB Pathway in Cancer Therapy

(2013) Derek J. Erstad et al.   Surgical Oncology Clinics of North America

Effects of PARP-1 Deficiency on Th1 and Th2 Cell Differentiation

(2013) M. Sambucci et al.   TheScientificWorldJOURNAL

Mycobacterial HBHA induces endoplasmic reticulum stress-mediated apoptosis through the generation of reactive oxygen species and cytosolic Ca2+ in murine macrophage RAW 264.7 cells

(2013) J-A Choi et al.   Cell Death & Disease

Oral intake of phenylbutyrate with or without vitamin D3upregulates the cathelicidin LL-37 in human macrophages: a dose finding study for treatment of tuberculosis

(2013) Akhirunnesa Mily et al.   BMC Pulmonary Medicine

MicroRNA-155 Promotes Autophagy to Eliminate Intracellular Mycobacteria by Targeting Rheb

(2013) Jinli Wang et al.   PLoS Pathogens

Mycobacterium tuberculosis Nucleoside Diphosphate Kinase Inactivates Small GTPases Leading to Evasion of Innate Immunity

(2013) Jim Sun et al.   PLoS Pathogens

Suppression of the Rho/Rho-Kinase Pathway and Prevention of Cerebral Vasospasm by Combination Treatment with Statin and Fasudil After Subarachnoid Hemorrhage in Rabbit

(2013) Masato Naraoka et al.   Translational Stroke Research

Beyond DNA Repair: Additional Functions of PARP-1 in Cancer

(2013) Alice N. Weaver et al.   Frontiers in Oncology

Metformin inhibits inflammatory response via AMPK–PTEN pathway in vascular smooth muscle cells

(2012) Sun Ae Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

Amelioration of Glucolipotoxicity-Induced Endoplasmic Reticulum Stress by a “Chemical Chaperone” in Human THP-1 Monocytes

(2012) Raji Lenin et al.   Experimental Diabetes Research

Sirtuin 1 Is a Key Regulator of the Interleukin-12 p70/Interleukin-23 Balance in Human Dendritic Cells

(2012) Yolanda Alvarez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Mycobacterial Infection by the Tumor Suppressor PTEN

(2012) Guochang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin D Suppression of Endoplasmic Reticulum Stress Promotes an Antiatherogenic Monocyte/Macrophage Phenotype in Type 2 Diabetic Patients

(2012) Amy E. Riek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive Oxygen Species in Health and Disease

(2012) Assim A. Alfadda et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Sitagliptin Exerts an Antinflammatory Action

(2012) Antoine Makdissi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Abelson Tyrosine Kinase Controls Phagosomal Acidification Required for Killing of Mycobacterium tuberculosis in Human Macrophages

(2012) H. Bruns et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis Modulates Macrophage Lipid-Sensing Nuclear Receptors PPAR  and TR4 for Survival

(2012) S. Mahajan et al.   JOURNAL OF IMMUNOLOGY

Natural Inhibitors of Poly(ADP-ribose) Polymerase-1

(2012) Marek Banasik et al.   MOLECULAR NEUROBIOLOGY

Endogenous viruses: insights into viral evolution and impact on host biology

(2012) Cédric Feschotte et al.   NATURE REVIEWS GENETICS

Uptake and Accumulation of Oxidized Low-Density Lipoprotein during Mycobacterium tuberculosis Infection in Guinea Pigs

(2012) Gopinath S. Palanisamy et al.   PLoS One

Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell tolerance

(2012) B. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-ribose) regulates post-transcriptional gene regulation in the cytoplasm

(2012) Anthony K.L. Leung et al.   RNA Biology

Signaling Mechanism of Poly(ADP-Ribose) Polymerase-1 (PARP-1) in Inflammatory Diseases

(2011) Xueqing Ba et al.   AMERICAN JOURNAL OF PATHOLOGY

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Small-Molecule Allosteric Activators of Sirtuins

(2011) David A. Sinclair et al.   Annual Review of Pharmacology and Toxicology

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

(2011) Véronique Plantevin Krenitsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

LOX-1 and Angiotensin Receptors, and Their Interplay

(2011) Xianwei Wang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Imatinib-Sensitive Tyrosine Kinases Regulate Mycobacterial Pathogenesis and Represent Therapeutic Targets against Tuberculosis

(2011) Ruth J. Napier et al.   Cell Host & Microbe

Recent Advances in the Therapeutic Perspectives of Nutlin-3

(2011) Paola Secchiero et al.   CURRENT PHARMACEUTICAL DESIGN

The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+

(2011) Zachary Gerhart-Hines et al.   MOLECULAR CELL

Coenzyme Q10 suppresses oxLDL-induced endothelial oxidative injuries by the modulation of LOX-1-mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway

(2011) Kun-Ling Tsai et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Sirtuins, Aging, and Medicine

(2011) Leonard Guarente   NEW ENGLAND JOURNAL OF MEDICINE

Endoplasmic Reticulum Stress Pathway-Mediated Apoptosis in Macrophages Contributes to the Survival of Mycobacterium tuberculosis

(2011) Yun-Ji Lim et al.   PLoS One

SIRT6 Promotes DNA Repair Under Stress by Activating PARP1

(2011) Z. Mao et al.   SCIENCE

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

CD36 deficiency attenuates experimental mycobacterial infection

(2010) Michael Hawkes et al.   BMC INFECTIOUS DISEASES

Endoplasmic reticulum stress response is involved inMycobacterium tuberculosisprotein ESAT-6-mediated apoptosis

(2010) Hong-Hee Choi et al.   FEBS LETTERS

Regulation of MKP-1 expression and MAPK activation by PARP-1 in oxidative stress: A new mechanism for the cytoplasmic effect of PARP-1 activation

(2010) Boglarka Racz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of High-Mobility Group Box 1 Protein and Poly(ADP-Ribose) Polymerase 1 Degradation in Chlamydia trachomatis-Induced Cytopathicity

(2010) H. Yu et al.   INFECTION AND IMMUNITY

Trypanosoma cruziInduces the Reactive Oxygen Species-PARP-1-RelA Pathway for Up-regulation of Cytokine Expression in Cardiomyocytes

(2010) Xueqing Ba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ellagic acid inhibits oxidized LDL-mediated LOX-1 expression, ROS generation, and inflammation in human endothelial cells

(2010) Wen-Jane Lee et al.   JOURNAL OF VASCULAR SURGERY

Induction of ER Stress in Macrophages of Tuberculosis Granulomas

(2010) Tracie A. Seimon et al.   PLoS One

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