Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies

Erratum to: Enhancing the Antitumor Activity of Berberine Hydrochloride by Solid Lipid Nanoparticle Encapsulation

(2014) Lu Wang et al.   AAPS PHARMSCITECH

Obesity and Type 2 Diabetes in Children: Epidemiology and Treatment

(2014) Elizabeth R. Pulgaron et al.   Current Diabetes Reports

Pharmacokinetic and toxicological considerations for the treatment of diabetes in patients with liver disease

(2014) André J Scheen   Expert Opinion on Drug Metabolism & Toxicology

Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability

(2014) Meng Zhaojie et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Youth-Onset Type 2 Diabetes Mellitus: Lessons Learned From the TODAY Study

(2014) Sumana Narasimhan et al.   MAYO CLINIC PROCEEDINGS

Mitochondria and NMDA Receptor-Dependent Toxicity of Berberine Sensitizes Neurons to Glutamate and Rotenone Injury

(2014) Kai Kysenius et al.   PLoS One

The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice

(2013) Chunfen Mo et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

Standards of Medical Care in Diabetes--2014

(2013)   DIABETES CARE

Global estimates of diabetes prevalence for 2013 and projections for 2035

(2013) L. Guariguata et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Effects of berberine on lipid profile in subjects with low cardiovascular risk

(2013) Giuseppe Derosa et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice

(2013) Karina Huynh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles

(2013) Mei Xue et al.   International Journal of Nanomedicine

Berberine Ameliorates Cold and Mechanical Allodynia in a Rat Model of Diabetic Neuropathy

(2013) Si Oh Kim et al.   JOURNAL OF MEDICINAL FOOD

Effect of Berberine Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion

(2013) Karina G. Pérez-Rubio et al.   Metabolic Syndrome and Related Disorders

Berberine improves insulin resistance in cardiomyocytes via activation of 5′-adenosine monophosphate-activated protein kinase

(2013) Wenguang Chang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling

(2013) Xi Xie et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Metformin therapy and kidney disease: a review of guidelines and proposals for metformin withdrawal around the world

(2013) Farshad Kajbaf et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Berberine rescues d-galactose-induced synaptic/memory impairment by regulating the levels of Arc

(2013) Pei-Yan Zhan et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Berberine Inhibits the Release of Glutamate in Nerve Terminals from Rat Cerebral Cortex

(2013) Tzu-Yu Lin et al.   PLoS One

Effect of berberine on insulin resistance in women with polycystic ovary syndrome: study protocol for a randomized multicenter controlled trial

(2013) Yan Li et al.   Trials

Synthesis and structure–activity relationship of berberine analogues in LDLR up-regulation and AMPK activation

(2012) Yan-Xiang Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Berberine Attenuates Ischemia-Reperfusion Injury Via Regulation of Adenosine-5′-monophosphate Kinase Activity in Both Non-ischemic and Ischemic Areas of the Rat Heart

(2012) Wenguang Chang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Berberine activates Nrf2 nuclear translocation and protects against oxidative damage via a phosphatidylinositol 3-kinase/Akt-dependent mechanism in NSC34 motor neuron-like cells

(2012) Ya-Yun Hsu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Berberine suppresses high glucose-induced TGF-β1 and fibronectin synthesis in mesangial cells through inhibition of sphingosine kinase 1/AP-1 pathway

(2012) Tian Lan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hippocampal synaptic plasticity restoration and anti-apoptotic effect underlie berberine improvement of learning and memory in streptozotocin-diabetic rats

(2012) Hamid Kalalian-Moghaddam et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Berberine improves endothelial function by reducing endothelial microparticles-mediated oxidative stress in humans

(2012) Fei Cheng et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Safety evaluation of main alkaloids from Rhizoma Coptidis

(2012) Jun Yi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis

(2012) Ming Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats

(2012) Feng Ling Wang et al.   MOLECULAR BIOLOGY REPORTS

Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin

(2012) Duo Wu et al.   PHYTOMEDICINE

Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control

(2012) Francesco Di Pierro Francesco et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients

(2011) Giuseppe Marazzi et al.   ADVANCES IN THERAPY

The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications

(2011) Bianca Marmontel de Souza et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Berberine exerts anti-adipogenic activity through up-regulation of C/EBP inhibitors, CHOP and DEC2

(2011) Truc P.T. Pham et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

(2011) Ana P. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effect of berberine on expressions of uncoupling protein-2 mRNA and protein in hepatic tissue of non-alcoholic fatty liver disease in rats

(2011) Qin-he Yang et al.   Chinese Journal of Integrative Medicine

Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway

(2011) Xi Xie et al.   ENDOCRINE JOURNAL

Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver

(2011) Lian-Jun Xing et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Berberine-induced Haemolysis Revisited: Safety of Rhizoma coptidis and Cortex phellodendri in Chronic Haematological Diseases

(2011) Yeh-ching Linn et al.   PHYTOTHERAPY RESEARCH

Activation of AMP-Activated Protein Kinase Is Required for Berberine-Induced Reduction of Atherosclerosis in Mice: The Role of Uncoupling Protein 2

(2011) Qilong Wang et al.   PLoS One

Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK–S1P signaling pathway

(2010) Tian Lan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Berberine inhibits NADPH oxidase mediated superoxide anion production in macrophagesThis article is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Lindsei K. Sarna et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Protective effect of berberine on antioxidant enzymes and positive transcription elongation factor b expression in diabetic rat liver

(2010) Ji-Yin Zhou et al.   FITOTERAPIA

Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research

(2010) Minzhong Ye et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: Involvement of NF-κB signaling pathway

(2010) Qin Jiang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity

(2009) Woo Sik Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Modulation of glucagon-like peptide-1 release by berberine: In vivo and in vitro studies

(2009) Yunli Yu et al.   BIOCHEMICAL PHARMACOLOGY

Ameliorative effect of berberine on endothelial dysfunction in diabetic rats induced by high-fat diet and streptozotocin

(2009) Chunmei Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Berberine inhibits adipogenesis in high-fat diet-induced obesity mice

(2009) Yueshan Hu et al.   FITOTERAPIA

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

(2009) Hao Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Reduction of blood lipid by berberine in hyperlipidemic patients with chronic hepatitis or liver cirrhosis

(2008) Wei Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: A Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action

(2008) N. Turner et al.   DIABETES

Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine

(2008) Yifei Zhang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Berberine promotes glucagon-like peptide-1 (7–36) amide secretion in streptozotocin-induced diabetic rats

(2008) Shou-Si Lu et al.   JOURNAL OF ENDOCRINOLOGY

Efficacy of berberine in patients with type 2 diabetes mellitus

(2008) Jun Yin et al.   METABOLISM-CLINICAL AND EXPERIMENTAL