Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control

The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by interferon-γ

(2015) Rui Appelberg et al.   IMMUNOLOGY

The balance between protective and pathogenic immune responses in the TB-infected lung

(2015) Ian M Orme et al.   NATURE IMMUNOLOGY

BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells

(2015) Andrea Cruz et al.   VACCINE

SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages

(2014) Ae Sin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A novel role of SIRT1 in gammaherpesvirus latency and replication

(2014) Meilan He et al.   CELL CYCLE

Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT2 down-regulates its enzymatic activity

(2014) Takeshi Tsusaka et al.   GENES TO CELLS

Activation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) by Inhibitors of Class III Histone Deacetylases: Identification of Sirtuin 1 as a Regulator of the KSHV Life Cycle

(2014) Q. Li et al.   JOURNAL OF VIROLOGY

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

SIRT2 Deficiency Modulates Macrophage Polarization and Susceptibility to Experimental Colitis

(2014) Giuseppe Lo Sasso et al.   PLoS One

Sirtuins Are Evolutionarily Conserved Viral Restriction Factors

(2014) Emre Koyuncu et al.   mBio

Sirt2 suppresses inflammatory responses in collagen-induced arthritis

(2013) Jiangtao Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TB: the Yin and Yang of lipid mediators

(2013) David M Tobin et al.   CURRENT OPINION IN PHARMACOLOGY

The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

(2013) Teresa Faria Pais et al.   EMBO JOURNAL

Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages

(2013) Maria Teixeira-Coelho et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

PEP-1–SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages

(2013) Mi Jin Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatitis C virus core protein induces hepatic metabolism disorders through down-regulation of the SIRT1–AMPK signaling pathway

(2013) Jian-Wu Yu et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Sirtuin 1 Regulates Hepatitis B Virus Transcription and Replication by Targeting Transcription Factor AP-1

(2013) J.-H. Ren et al.   JOURNAL OF VIROLOGY

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response

(2013) Jenny Carmona et al.   PLoS One

Myeloid Cell Sirtuin-1 Expression Does Not Alter Host Immune Responses to Gram-Negative Endotoxemia or Gram-Positive Bacterial Infection

(2013) Laura E. Crotty Alexander et al.   PLoS One

A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection

(2013) H. A. Eskandarian et al.   SCIENCE

Are sirtuins viable targets for improving healthspan and lifespan?

(2012) Joseph A. Baur et al.   NATURE REVIEWS DRUG DISCOVERY

For better or for worse: the immune response against Mycobacterium tuberculosis balances pathology and protection

(2011) Anca Dorhoi et al.   IMMUNOLOGICAL REVIEWS

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

TLR2 deficiency by compromising p19 (IL-23) expression limits Th 17 cell responses to Mycobacterium tuberculosis

(2010) Maria Teixeira-Coelho et al.   INTERNATIONAL IMMUNOLOGY

SIRT2 regulates NF- B-dependent gene expression through deacetylation of p65 Lys310

(2010) K. M. Rothgiesser et al.   JOURNAL OF CELL SCIENCE

Cell-Mediated Immune Responses in Tuberculosis

(2009) Andrea M. Cooper   Annual Review of Immunology

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

(2009) J. van Loosdregt et al.   BLOOD

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages

(2009) Ran Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T Cell Hyperactivation

(2008) Hye-Sook Kwon et al.   Cell Host & Microbe