Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth

TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species

(2013) Francisco J. Roca et al.   CELL

Integration of Chemical and RNAi Multiparametric Profiles Identifies Triggers of Intracellular Mycobacterial Killing

(2013) Varadharajan Sundaramurthy et al.   Cell Host & Microbe

Serotonin Skews Human Macrophage Polarization through HTR2B and HTR7

(2013) M. de las Casas-Engel et al.   JOURNAL OF IMMUNOLOGY

Corticosteroids for prevention of mortality in people with tuberculosis: a systematic review and meta-analysis

(2013) Julia A Critchley et al.   LANCET INFECTIOUS DISEASES

Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32

(2013) S. A. Stanley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening

(2012) Sarah A. Stanley et al.   ACS Chemical Biology

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

(2012) David M. Tobin et al.   CELL

Mycobacterium tuberculosis-Driven Targeted Recalibration of Macrophage Lipid Homeostasis Promotes the Foamy Phenotype

(2012) Varshneya Singh et al.   Cell Host & Microbe

Efferocytosis Is an Innate Antibacterial Mechanism

(2012) Constance J. Martin et al.   Cell Host & Microbe

Abelson Tyrosine Kinase Controls Phagosomal Acidification Required for Killing of Mycobacterium tuberculosis in Human Macrophages

(2012) H. Bruns et al.   JOURNAL OF IMMUNOLOGY

Linezolid for Treatment of Chronic Extensively Drug-Resistant Tuberculosis

(2012) Myungsun Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Successful Shortening of Tuberculosis Treatment Using Adjuvant Host-Directed Therapy with FDA-Approved Phosphodiesterase Inhibitors in the Mouse Model

(2012) Mamoudou Maiga et al.   PLoS One

Adjunctive TNF Inhibition with Standard Treatment Enhances Bacterial Clearance in a Murine Model of Necrotic TB Granulomas

(2012) Ciaran Skerry et al.   PLoS One

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

Imatinib-Sensitive Tyrosine Kinases Regulate Mycobacterial Pathogenesis and Represent Therapeutic Targets against Tuberculosis

(2011) Ruth J. Napier et al.   Cell Host & Microbe

Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Isoniazid Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice

(2011) Mi-Sun Koo et al.   PLoS One

Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans

(2011) J. L. Warner-Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs

(2011) Selvakumar Subbian et al.   PLoS Pathogens

Genome-wide Analysis of the Host Intracellular Network that Regulates Survival of Mycobacterium tuberculosis

(2010) Dhiraj Kumar et al.   CELL

Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis

(2010) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

(2010) J. B. Spangler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Host-Dependent Survival Factors for Intracellular Mycobacterium tuberculosis through an siRNA Screen

(2010) Shilpi Jayaswal et al.   PLoS Pathogens

The Epidermal Growth Factor Receptor (EGFR) Promotes Uptake of Influenza A Viruses (IAV) into Host Cells

(2010) Thorsten Eierhoff et al.   PLoS Pathogens

Mycobacterium tuberculosis Eis Regulates Autophagy, Inflammation, and Cell Death through Redox-dependent Signaling

(2010) Dong-Min Shin et al.   PLoS Pathogens

Chemical Tools for Dissecting Bacterial Physiology and Virulence

(2009) Sarah A. Stanley et al.   BIOCHEMISTRY

Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP

(2009) Jemma L Webber et al.   EMBO JOURNAL

Epidermal Growth Factor Receptor Activation Protects Gastric Epithelial Cells From Helicobacter pylori-Induced Apoptosis

(2009) Fang Yan et al.   GASTROENTEROLOGY

Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice

(2009) Hannelie Korf et al.   JOURNAL OF CLINICAL INVESTIGATION

Voltage Gated Calcium Channels Negatively Regulate Protective Immunity to Mycobacterium tuberculosis

(2009) Shashank Gupta et al.   PLoS One

High Content Screening Identifies Decaprenyl-Phosphoribose 2′ Epimerase as a Target for Intracellular Antimycobacterial Inhibitors

(2009) Thierry Christophe et al.   PLoS Pathogens

Mycobacterium tuberculosis Prevents Inflammasome Activation

(2008) Sharon S. Master et al.   Cell Host & Microbe

Infections Due to Various Atypical Mycobacteria in a Norwegian Multiplex Family with Dominant Interferon-  Receptor Deficiency

(2008) H. Glosli et al.   CLINICAL INFECTIOUS DISEASES

Epidermal Growth Factor Receptor Signaling to Erk1/2 and STATs Control the Intensity of the Epithelial Inflammatory Responses to Rhinovirus Infection

(2008) Kenneth Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2and LXA4in the induction of macrophage death

(2008) Minjian Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Probing Host Pathogen Cross-Talk by Transcriptional Profiling of Both Mycobacterium tuberculosis and Infected Human Dendritic Cells and Macrophages

(2008) Ludovic Tailleux et al.   PLoS One

Host-Directed Drug Targeting of Factors Hijacked by Pathogens

(2008) A. Schwegmann et al.   Science Signaling

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens