Leishmania infantum Modulates Host Macrophage Mitochondrial Metabolism by Hijacking the SIRT1-AMPK Axis

Functional Dichotomy of Dendritic Cells following Interaction with Leishmania braziliensis: Infected Cells Produce High Levels of TNF- , whereas Bystander Dendritic Cells Are Activated to Promote T Cell Responses

(2014) L. P. Carvalho et al.   JOURNAL OF IMMUNOLOGY

Extracellular Vesicles from Leishmania-Infected Macrophages Confer an Anti-infection Cytokine-Production Profile to Naïve Macrophages

(2014) André Cronemberger-Andrade et al.   PLoS Neglected Tropical Diseases

Impairment of T Cell Function in Parasitic Infections

(2014) Vasco Rodrigues et al.   PLoS Neglected Tropical Diseases

Host Metabolism Regulates Intracellular Growth of Trypanosoma cruzi

(2013) Kacey L. Caradonna et al.   Cell Host & Microbe

Leishmania-Infected MHC Class IIhigh Dendritic Cells Polarize CD4+ T Cells toward a Nonprotective T-bet+ IFN- + IL-10+ Phenotype

(2013) M. Resende et al.   JOURNAL OF IMMUNOLOGY

Exoproteome dynamics in Leishmania infantum

(2013) Nuno Santarém et al.   Journal of Proteomics

Characterization of the biology and infectivity of Leishmania infantum viscerotropic and dermotropic strains isolated from HIV+ and HIV- patients in the murine model of visceral leishmaniasis

(2013) Joana Cunha et al.   Parasites & Vectors

Cytokine and nitric oxide patterns in dogs immunized with LBSap vaccine, before and after experimental challenge with Leishmania chagasi plus saliva of Lutzomyia longipalpis

(2013) Lucilene Aparecida Resende et al.   VETERINARY PARASITOLOGY

STAT6 promotes bi-directional modulation of PKM2 in liver and adipose inflammatory cells in Rosiglitazone-treated mice

(2013) Tatjana Sajic et al.   Scientific Reports

Immunomodulatory Impact of Leishmania-Induced Macrophage Exosomes: A Comparative Proteomic and Functional Analysis

(2013) Kasra Hassani et al.   PLoS Neglected Tropical Diseases

Feeding Uninvited Guests: mTOR and AMPK Set the Table for Intracellular Pathogens

(2013) Jason Brunton et al.   PLoS Pathogens

PGC1  and mitochondrial metabolism - emerging concepts and relevance in ageing and neurodegenerative disorders

(2012) S. Austin et al.   JOURNAL OF CELL SCIENCE

Impact of Continuous Axenic Cultivation in Leishmania infantum Virulence

(2012) Diana Moreira et al.   PLoS Neglected Tropical Diseases

Transcriptomic Signature of Leishmania Infected Mice Macrophages: A Metabolic Point of View

(2012) Imen Rabhi et al.   PLoS Neglected Tropical Diseases

Leishmania Repression of Host Translation through mTOR Cleavage Is Required for Parasite Survival and Infection

(2011) Maritza Jaramillo et al.   Cell Host & Microbe

Modulation of mammalian apoptotic pathways by intracellular protozoan parasites

(2011) V. Rodrigues et al.   CELLULAR MICROBIOLOGY

SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice

(2011) Erin L. Seifert et al.   FASEB JOURNAL

The Leishmania nicotinamidase is essential for NAD+ production and parasite proliferation

(2011) E. Gazanion et al.   MOLECULAR MICROBIOLOGY

Viruses and the fuel sensor: the emerging link between AMPK and virus replication

(2011) Jamel Mankouri et al.   REVIEWS IN MEDICAL VIROLOGY

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial Fusion Is Required for mtDNA Stability in Skeletal Muscle and Tolerance of mtDNA Mutations

(2010) Hsiuchen Chen et al.   CELL

Activated macrophages utilize glycolytic ATP to maintain mitochondrial membrane potential and prevent apoptotic cell death

(2010) A Garedew et al.   CELL DEATH AND DIFFERENTIATION

AMPK inhibition in health and disease

(2010) Benoit Viollet et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

A Membrane Protease Regulates Energy Production in Macrophages by Activating Hypoxia-inducible Factor-1 via a Non-proteolytic Mechanism

(2010) Takeharu Sakamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

(2010) Eric Verdin et al.   TRENDS IN BIOCHEMICAL SCIENCES

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

(2008) Marcella Fulco et al.   DEVELOPMENTAL CELL

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY