Advances in Nonviral mRNA Delivery Materials and Their Application as Vaccines for Melanoma Therapy

Structure and Function of Cationic and Ionizable Lipids for Nucleic Acid Delivery

(2023) Da Sun et al.   PHARMACEUTICAL RESEARCH

Polymer‐Based mRNA Delivery Strategies for Advanced Therapies

(2023) Wenqian Yang et al.   Advanced Healthcare Materials

Evolution and Progress of mRNA Vaccines in the Treatment of Melanoma: Future Prospects

(2023) Dimitrios Bafaloukos et al.   Vaccines

Lipid–Polymer Hybrid Nanoparticles Utilize B Cells and Dendritic Cells to Elicit Distinct Antigen-Specific CD4+ and CD8+ T Cell Responses

(2023) Michael H. Zhang et al.   ACS Applied Bio Materials

Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery

(2022) Masatoshi Maeki et al.   JOURNAL OF CONTROLLED RELEASE

Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis

(2022) Min Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy

(2022) Jin-Qing Liu et al.   JOURNAL OF CONTROLLED RELEASE

Cancer vaccines as promising immuno-therapeutics: platforms and current progress

(2022) Jian Liu et al.   Journal of Hematology & Oncology

SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis

(2022) Tobias Boettler et al.   JOURNAL OF HEPATOLOGY

Modification of Lipid-Based Nanoparticles: An Efficient Delivery System for Nucleic Acid-Based Immunotherapy

(2022) Chi Zhang et al.   MOLECULES

The clinical progress of mRNA vaccines and immunotherapies

(2022) Ann J. Barbier et al.   NATURE BIOTECHNOLOGY

Combinatorial optimization of mRNA structure, stability, and translation for RNA-based therapeutics

(2022) Kathrin Leppek et al.   Nature Communications

mRNA Vaccines: The Dawn of a New Era of Cancer Immunotherapy

(2022) Zhuoya Deng et al.   Frontiers in Immunology

Recent advancements in lipid–mRNA nanoparticles as a treatment option for cancer immunotherapy

(2022) Prajeena Karmacharya et al.   Journal of Pharmaceutical Investigation

Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

(2022) Yi Ju et al.   ACS Nano

The Treatment of Advanced Melanoma: Therapeutic Update

(2022) Alessia Villani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipid nanoparticles in the development of mRNA vaccines for COVID-19

(2022) Barnabas Wilson et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8 + T cell response

(2022) Jinjin Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety Challenges and Application Strategies for the Use of Dendrimers in Medicine

(2022) Xiang Li et al.   Pharmaceutics

The Future of Tissue-Targeted Lipid Nanoparticle-Mediated Nucleic Acid Delivery

(2022) Ruvanthi N. Kularatne et al.   Pharmaceuticals

The role of lipid components in lipid nanoparticles for vaccines and gene therapy

(2022) Camilla Hald Albertsen et al.   ADVANCED DRUG DELIVERY REVIEWS

Poly (beta‐amino ester) as an In Vivo Nanocarrier for Therapeutic Nucleic Acids

(2022) Muhammad Sadeqi Nezhad   BIOTECHNOLOGY AND BIOENGINEERING

Ionic liquid-mediated delivery of a BCL-2 inhibitor for topical treatment of skin melanoma

(2022) Md Nurul Huda et al.   JOURNAL OF CONTROLLED RELEASE

Clinical advances and ongoing trials of mRNA vaccines for cancer treatment

(2022) Cathrine Lund Lorentzen et al.   LANCET ONCOLOGY

Fluoroalkane modified cationic polymers for personalized mRNA cancer vaccines

(2022) Junyan Li et al.   CHEMICAL ENGINEERING JOURNAL

mRNA vaccines for cancer immunotherapy

(2022) Yashavantha L. Vishweshwaraiah et al.   Frontiers in Immunology

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

(2021) Eryn Blass et al.   Nature Reviews Clinical Oncology

Identification of 3′ UTR motifs required for mRNA localization to myelin sheaths in vivo

(2021) Katie M. Yergert et al.   PLOS BIOLOGY

Biological implications of decapping: beyond bulk mRNA decay

(2021) Fivos Borbolis et al.   FEBS Journal

mRNA vaccine for cancer immunotherapy

(2021) Lei Miao et al.   Molecular Cancer

mRNA in cancer immunotherapy: beyond a source of antigen

(2021) Lien Van Hoecke et al.   Molecular Cancer

Delivery of mRNA vaccine with a lipid-like material potentiates antitumor efficacy through Toll-like receptor 4 signaling

(2021) Hongxia Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anaphylactic reactions to novel mRNA SARS-CoV-2/COVID-19 vaccines

(2021) John M. Kelso   VACCINE

Polymeric Delivery of Therapeutic Nucleic Acids

(2021) Ramya Kumar et al.   CHEMICAL REVIEWS

Recent Advances in Preclinical Research Using PAMAM Dendrimers for Cancer Gene Therapy

(2021) Piotr Tarach et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipid Nanoparticles—From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement

(2021) Rumiana Tenchov et al.   ACS Nano

Treatment of Melanoma by Nano-conjugate-Delivered Wee1 siRNA

(2021) Xueyan Zhang et al.   MOLECULAR PHARMACEUTICS

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months

(2021) Stephen J. Thomas et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-throughput 5′ UTR engineering for enhanced protein production in non-viral gene therapies

(2021) Jicong Cao et al.   Nature Communications

CpG Oligodeoxynucleotide Developed to Activate Primate Immune Responses Promotes Antitumoral Effects in Combination with a Neoantigen-Based mRNA Cancer Vaccine

(2021) Qin Li et al.   Drug Design Development and Therapy

Chemistry of Lipid Nanoparticles for RNA Delivery

(2021) Yulia Eygeris et al.   ACCOUNTS OF CHEMICAL RESEARCH

Immunogenicity of In Vitro-Transcribed RNA

(2021) Xin Mu et al.   ACCOUNTS OF CHEMICAL RESEARCH

COVID 19 vaccine distribution solution to the last mile challenge: Experimental and simulation studies of ultra-low temperature refrigeration system

(2021) Jian Sun et al.   INTERNATIONAL JOURNAL OF REFRIGERATION-REVUE INTERNATIONALE DU FROID

Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale

(2021) Prasath Paramasivam et al.   JOURNAL OF CELL BIOLOGY

Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression

(2021) Lori A. Passmore et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An ionizable lipid toolbox for RNA delivery

(2021) Xuexiang Han et al.   Nature Communications

539 Phase 1 study of mRNA-2752, a lipid nanoparticle encapsulating mRNAs encoding human OX40L/IL-23/IL-36γ, for intratumoral (ITu) injection +/- durvalumab in advanced solid tumors and lymphoma

(2021) Manish Patel et al.   Journal for ImmunoTherapy of Cancer

New Applications of Lipid and Polymer-Based Nanoparticles for Nucleic Acids Delivery

(2021) Adelina-Gabriela Niculescu et al.   Pharmaceutics

mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients

(2021) Maryam Bidram et al.   Vaccines

Synthesis of low immunogenicity RNA with high-temperature in vitro transcription

(2020) Monica Z. Wu et al.   RNA

Integration of Polylactide into Polyethylenimine Facilitates the Safe and Effective Intracellular siRNA Delivery

(2020) Guo-Bin Ding et al.   Polymers

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

(2020) Abishek Wadhwa et al.   Pharmaceutics

PAMAM Dendrimer Nanomolecules Utilized as Drug Delivery Systems for Potential Treatment of Glioblastoma: A Systematic Review

(2020) Michael Fana et al.   International Journal of Nanomedicine

Non-adhesive and highly stable biodegradable nanoparticles that provide widespread and safe transgene expression in orthotopic brain tumors

(2020) Karina Negron et al.   Drug Delivery and Translational Research

Polymeric vehicles for nucleic acid delivery

(2020) Alexandra S. Piotrowski-Daspit et al.   ADVANCED DRUG DELIVERY REVIEWS

A randomized controlled phase II clinical trial on mRNA electroporated autologous monocyte-derived dendritic cells (TriMixDC-MEL) as adjuvant treatment for stage III/IV melanoma patients who are disease-free following the resection of macrometastases

(2020) Yanina Jansen et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities

(2020) Johan Karlsson et al.   Expert Opinion on Drug Delivery

Decoding mRNA translatability and stability from the 5′ UTR

(2020) Longfei Jia et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Immunotherapy in the Treatment of Metastatic Melanoma: Current Knowledge and Future Directions

(2020) Massimo Ralli et al.   Journal of Immunology Research

PEI fluorination reduces toxicity and promotes liver-targeted siRNA delivery

(2020) Lian Xue et al.   Drug Delivery and Translational Research

Emerging Roles of RNA 3′-end Cleavage and Polyadenylation in Pathogenesis, Diagnosis and Therapy of Human Disorders

(2020) Jamie Nourse et al.   Biomolecules

Leveraging mRNA Sequences and Nanoparticles to Deliver SARS‐CoV‐2 Antigens In Vivo

(2020) Chunxi Zeng et al.   ADVANCED MATERIALS

mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

(2020) Gal Cafri et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphodiester modifications in mRNA polyA tail prevent deadenylation without compromising protein expression

(2020) Dominika Strzelecka et al.   RNA

Selecting Target Antigens for Cancer Vaccine Development

(2020) Luigi Buonaguro et al.   Vaccines

Efficient ovalbumin delivery using a novel multifunctional micellar platform for targeted melanoma immunotherapy

(2019) Muye He et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Delivery technologies for cancer immunotherapy

(2019) Rachel S. Riley et al.   NATURE REVIEWS DRUG DISCOVERY

Multiple covalent fluorescence labeling of eukaryotic mRNA at the poly(A) tail enhances translation and can be performed in living cells

(2019) Lea Anhäuser et al.   NUCLEIC ACIDS RESEARCH

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

(2019) Piotr S. Kowalski et al.   MOLECULAR THERAPY

ALYREF links 3′‐end processing to nuclear export of non‐polyadenylated mRNAs

(2019) Jing Fan et al.   EMBO JOURNAL

A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA

(2019) Markus Baiersdörfer et al.   Molecular Therapy-Nucleic Acids

Tuning of mRNA stability through altering 3′-UTR sequences generates distinct output expression in a synthetic circuit driven by p53 oscillations

(2019) Woo Seuk Koh et al.   Scientific Reports

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

(2019) Lei Miao et al.   NATURE BIOTECHNOLOGY

Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response

(2019) Sergio Linares-Fernández et al.   TRENDS IN MOLECULAR MEDICINE

Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

(2019) F. Zhang et al.   Nature Communications

mRNA Recruiting eIF4 Factors Involved in Protein Synthesis and Its Regulation

(2019) Rishi Kumar Mishra et al.   BIOCHEMISTRY

Mechanistic insights into mRNA 3′-end processing

(2019) Ananthanarayanan Kumar et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

(2019) Ana Santos et al.   Materials

Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine

(2018) Hyokyoung Kwon et al.   BIOMATERIALS

Modified ARCA analogs providing enhanced translational properties of capped mRNAs

(2018) Ilona Kocmik et al.   CELL CYCLE

Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells

(2018) A. Le Moignic et al.   JOURNAL OF CONTROLLED RELEASE

Dendritic Cell–Based Cancer Vaccines

(2018) Patricia M. Santos et al.   JOURNAL OF IMMUNOLOGY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

An origin of the immunogenicity of in vitro transcribed RNA

(2018) Xin Mu et al.   NUCLEIC ACIDS RESEARCH

Intradermal delivery of STAT3 siRNA to treat melanoma via dissolving microneedles

(2018) Jingtong Pan et al.   Scientific Reports

Uridine Depletion and Chemical Modification Increase Cas9 mRNA Activity and Reduce Immunogenicity without HPLC Purification

(2018) Sriram Vaidyanathan et al.   Molecular Therapy-Nucleic Acids

Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

(2018) Kevin Van der Jeught et al.   ACS Nano

mRNA cap regulation in mammalian cell function and fate

(2018) Alison Galloway et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Worm-Like Biomimetic Nanoerythrocyte Carrying siRNA for Melanoma Gene Therapy

(2018) Yanming Wang et al.   Small

The Role of the Eukaryotic Translation Initiation Factor 4E (eIF4E) in Neuropsychiatric Disorders

(2018) Inês S. Amorim et al.   Frontiers in Genetics

Mechanism of action of mRNA-based vaccines

(2017) Carlo Iavarone et al.   Expert Review of Vaccines

Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them

(2017) Kathrin Leppek et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Short poly(A) tails are a conserved feature of highly expressed genes

(2017) Sarah Azoubel Lima et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Overview of the Changing Landscape of Treatment for Advanced Melanoma

(2017) Chung-Shien Lee et al.   PHARMACOTHERAPY

Architecture of eukaryotic mRNA 3′-end processing machinery

(2017) Ana Casañal et al.   SCIENCE

Short poly(A) tails are a conserved feature of highly expressed genes

(2017) Sarah Azoubel Lima et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Langerhans-type dendritic cells electroporated with TRP-2 mRNA stimulate cellular immunity against melanoma: Results of a phase I vaccine trial

(2017) David J. Chung et al.   OncoImmunology

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery

(2016) Xinwei Cheng et al.   ADVANCED DRUG DELIVERY REVIEWS

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Phase II Study of Autologous Monocyte-Derived mRNA Electroporated Dendritic Cells (TriMixDC-MEL) Plus Ipilimumab in Patients With Pretreated Advanced Melanoma

(2016) Sofie Wilgenhof et al.   JOURNAL OF CLINICAL ONCOLOGY

Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways

(2016) Man Li et al.   JOURNAL OF CONTROLLED RELEASE

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy

(2016) Matthias A. Oberli et al.   NANO LETTERS

mRNA capping: biological functions and applications

(2016) Anand Ramanathan et al.   NUCLEIC ACIDS RESEARCH

Processing and transcriptome expansion at the mRNA 3′ end in health and disease: finding the right end

(2016) Anton Ogorodnikov et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A general method for rapid and cost-efficient large-scale production of 5′ capped RNA

(2016) Anna-Lisa Fuchs et al.   RNA

Lipopolyplex for Therapeutic Gene Delivery and Its Application for the Treatment of Parkinson’s Disease

(2016) Wei Chen et al.   Frontiers in Aging Neuroscience

pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences

(2016) Alexandra E Grier et al.   Molecular Therapy-Nucleic Acids

mRNA-transfected dendritic cell vaccine in combination with metronomic cyclophosphamide as treatment for patients with advanced malignant melanoma

(2016) Troels Holz Borch et al.   OncoImmunology

Immune response and long-term clinical outcome in advanced melanoma patients vaccinated with tumor-mRNA-transfected dendritic cells

(2016) Jon Amund Kyte et al.   OncoImmunology

Topical and Targeted Delivery of siRNAs to Melanoma Cells Using a Fusion Peptide Carrier

(2016) Renquan Ruan et al.   Scientific Reports

Induction of HIV-1 gag specific immune responses by cationic micelles mediated delivery of gag mRNA

(2015) Mengnan Zhao et al.   DRUG DELIVERY

Tweaking dendrimers and dendritic nanoparticles for controlled nano-bio interactions: potential nanocarriers for improved cancer targeting

(2015) Jason Bugno et al.   JOURNAL OF DRUG TARGETING

Dual Stimuli-Responsive Poly(β-amino ester) Nanoparticles for On-Demand Burst Release

(2015) Jung Seok Lee et al.   MACROMOLECULAR BIOSCIENCE

Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy

(2015) Panagiotis Mastorakos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intranodal vaccination with mRNA-optimized dendritic cells in metastatic melanoma patients

(2015) Kalijn F Bol et al.   OncoImmunology

Adjuvant dendritic cell vaccination in high-risk uveal melanoma patients

(2015) Kalijn Bol et al.   Journal for ImmunoTherapy of Cancer

Oligopeptide-terminated poly(β-amino ester)s for highly efficient gene delivery and intracellular localization

(2014) Nathaly Segovia et al.   Acta Biomaterialia

Trigger-responsive, fast-degradable poly(β-amino ester)s for enhanced DNA unpackaging and reduced toxicity

(2014) Xiaojian Deng et al.   BIOMATERIALS

Long-term clinical outcome of melanoma patients treated with messenger RNA-electroporated dendritic cell therapy following complete resection of metastases

(2014) Sofie Wilgenhof et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

IL-2: The First Effective Immunotherapy for Human Cancer

(2014) S. A. Rosenberg   JOURNAL OF IMMUNOLOGY

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

(2014) Joanna Kowalska et al.   NUCLEIC ACIDS RESEARCH

Cholesterol level affects surface charge of lipid membranes in saline solution

(2014) Aniket Magarkar et al.   Scientific Reports

Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo

(2014) Yizhou Dong et al.   Advanced Healthcare Materials

A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients

(2013) S. Wilgenhof et al.   ANNALS OF ONCOLOGY

Immunotherapy of melanoma

(2013) John B.A.G. Haanen   EJC SUPPLEMENTS

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Transfection efficiency boost of cholesterol-containing lipoplexes

(2012) Daniela Pozzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy

(2012) S. Van Lint et al.   CANCER RESEARCH

Vaccination with mRNA-Electroporated Dendritic Cells Induces Robust Tumor Antigen-Specific CD4+ and CD8+ T Cells Responses in Stage III and IV Melanoma Patients

(2012) E. H. J. G. Aarntzen et al.   CLINICAL CANCER RESEARCH

Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery

(2012) Rachel J. Fields et al.   JOURNAL OF CONTROLLED RELEASE

Dendritic Cells Loaded With mRNA Encoding Full-length Tumor Antigens Prime CD4+ and CD8+ T Cells in Melanoma Patients

(2012) An MT Van Nuffel et al.   MOLECULAR THERAPY

Polymers and Drug Delivery Systems

(2012) Gemma Vilar et al.   Current Drug Delivery

Rational design of smart supramolecular assemblies for gene delivery: chemical challenges in the creation of artificial viruses

(2011) Kanjiro Miyata et al.   CHEMICAL SOCIETY REVIEWS

Therapeutic Vaccination With an Autologous mRNA Electroporated Dendritic Cell Vaccine in Patients With Advanced Melanoma

(2011) Sofie Wilgenhof et al.   JOURNAL OF IMMUNOTHERAPY

Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA

(2011) Federico Perche et al.   Nanomedicine-Nanotechnology Biology and Medicine

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

PEGylation Improves Nanoparticle Formation and Transfection Efficiency of Messenger RNA

(2011) Senta Üzgün et al.   PHARMACEUTICAL RESEARCH

The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation

(2010) Ranit Kedmi et al.   BIOMATERIALS

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

(2010) A N Kuhn et al.   GENE THERAPY

Dendrimer toxicity: Let's meet the challenge

(2010) Keerti Jain et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Targeted Nanoparticles Deliver siRNA to Melanoma

(2010) Yunching Chen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Many Pathways of RNA Degradation

(2009) Jonathan Houseley et al.   CELL

Single-Step Antigen Loading and Activation of Dendritic Cells by mRNA Electroporation for the Purpose of Therapeutic Vaccination in Melanoma Patients

(2009) A. Bonehill et al.   CLINICAL CANCER RESEARCH

Degradable polyethylenimines as DNA and small interfering RNA carriers

(2009) D Jere et al.   Expert Opinion on Drug Delivery

Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

(2009) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

Biological basis for restriction of microRNA targets to the 3′ untranslated region in mammalian mRNAs

(2009) Shuo Gu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

3′ end mRNA processing: molecular mechanisms and implications for health and disease

(2008) Sven Danckwardt et al.   EMBO JOURNAL

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

(2008) Hendrik Poeck et al.   NATURE MEDICINE