Microfluidic technologies and devices for lipid nanoparticle-based RNA delivery

Design of SARS-CoV-2 hFc-Conjugated Receptor-Binding Domain mRNA Vaccine Delivered via Lipid Nanoparticles

(2021) Uri Elia et al.   ACS Nano

Ultra-small lipid nanoparticles encapsulating sorafenib and midkine-siRNA selectively-eradicate sorafenib-resistant hepatocellular carcinoma in vivo

(2021) Mahmoud A. Younis et al.   JOURNAL OF CONTROLLED RELEASE

Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach

(2021) Takeshi Terada et al.   LANGMUIR

Ionizable lipid nanoparticles for in utero mRNA delivery

(2021) Rachel S. Riley et al.   Science Advances

Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3

(2021) Min Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

(2021) Federica Sebastiani et al.   ACS Nano

Double flow focusing microfluidic-assisted based preparation of methotrexate–loaded liposomal nanoparticles: Encapsulation efficacy, drug release and stability

(2021) Halimeh Aghaei et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

(2021) Linde Schoenmaker et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Impact of lipid nanoparticle size on mRNA vaccine immunogenicity

(2021) Kimberly J. Hassett et al.   JOURNAL OF CONTROLLED RELEASE

Continuous Production of Lipid Nanoparticles by Ultrasound‐Assisted Microfluidic Antisolvent Precipitation

(2021) Holger Bolze et al.   CHEMICAL ENGINEERING & TECHNOLOGY

Parametric Study of the Factors Influencing Liposome Physicochemical Characteristics in a Periodic Disturbance Mixer

(2021) Rubén R. López et al.   LANGMUIR

Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device

(2021) Sarah J. Shepherd et al.   NANO LETTERS

Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant

(2021) Jamie Lopez Bernal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

(2020) Margaret M. Billingsley et al.   NANO LETTERS

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

(2020) Siddharth Patel et al.   Nature Communications

Microfluidic-Based Holonomic Constraints of siRNA in the Kernel of Lipid/Polymer Hybrid Nanoassemblies for Improving Stable and Safe In Vivo Delivery

(2020) Wei Wei et al.   ACS Applied Materials & Interfaces

Microfluidic Shrinking Droplet Concentrator for Analyte Detection and Phase Separation of Protein Solutions

(2020) Marie R. G. Kopp et al.   ANALYTICAL CHEMISTRY

Using microfluidics for scalable manufacturing of nanomedicines from bench to GMP: A case study using protein-loaded liposomes

(2020) Cameron Webb et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Microfluidic fabrication and characterization of Sorafenib-loaded lipid-polymer hybrid nanoparticles for controlled drug delivery

(2020) Nayab Tahir et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Global efforts on vaccines for COVID-19: Since, sooner or later, we all will catch the coronavirus

(2020) Raju Mukherjee   JOURNAL OF BIOSCIENCES

Hydrophobic Domain Structure of Linear-Dendritic Poly(ethylene glycol) Lipids Affects RNA Delivery of Lipid Nanoparticles

(2020) Kejin Zhou et al.   MOLECULAR PHARMACEUTICS

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Paper-Based Device for the Facile Colorimetric Determination of Lithium Ions in Human Whole Blood

(2020) Takeshi Komatsu et al.   ACS Sensors

Development of a Microfluidic-Based Post-Treatment Process for Size-Controlled Lipid Nanoparticles and Application to siRNA Delivery

(2020) Niko Kimura et al.   ACS Applied Materials & Interfaces

Self‐Degradable Lipid‐Like Materials Based on “Hydrolysis accelerated by the intra‐Particle Enrichment of Reactant (HyPER)” for Messenger RNA Delivery

(2020) Hiroki Tanaka et al.   ADVANCED FUNCTIONAL MATERIALS

In silico design and 3D printing of microfluidic chips for the preparation of size-controllable siRNA nanocomplexes

(2020) Yongquan Li et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Resveratrol Enhances mRNA and siRNA Lipid Nanoparticles Primary CLL Cell Transfection

(2020) Edo Kon et al.   Pharmaceutics

Real-Time Measurement of Protein Crystal Growth Rates within the Microfluidic Device to Understand the Microspace Effect

(2020) Masatoshi Maeki et al.   ACS Omega

COVID-19 Vaccine Frontrunners and Their Nanotechnology Design

(2020) Young Hun Chung et al.   ACS Nano

SARS-CoV-2 vaccines in development

(2020) Florian Krammer   NATURE

Preparation of cetyl palmitate-based PEGylated solid lipid nanoparticles by microfluidic technique

(2020) Ilaria Arduino et al.   Acta Biomaterialia

One-step non-competitive fluorescence polarization immunoassay based on a Fab fragment for C-reactive protein quantification

(2020) Keine Nishiyama et al.   SENSORS AND ACTUATORS B-CHEMICAL

Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfluidics

(2020) Carla B. Roces et al.   Pharmaceutics

Rapid, sensitive universal paper-based device enhances competitive immunoassays of small molecules

(2020) Takeshi Komatsu et al.   ANALYTICA CHIMICA ACTA

The effect of different organic solvents in liposome properties produced in a periodic disturbance mixer: Transcutol®, a potential organic solvent replacement

(2020) Rubén R. López et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Lipid nanoparticles loaded with ribonucleoprotein–oligonucleotide complexes synthesized using a microfluidic device exhibit robust genome editing and hepatitis B virus inhibition

(2020) Yuichi Suzuki et al.   JOURNAL OF CONTROLLED RELEASE

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

(2019) Kimberly J. Hassett et al.   Molecular Therapy-Nucleic Acids

Formulation and manufacturing of lymphatic targeting liposomes using microfluidics

(2019) Swapnil Khadke et al.   JOURNAL OF CONTROLLED RELEASE

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

(2018) Jayesh A. Kulkarni et al.   ACS Nano

Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems

(2018) Masatoshi Maeki et al.   ADVANCED DRUG DELIVERY REVIEWS

Ionizable Amino-Polyesters Synthesized via Ring Opening Polymerization of Tertiary Amino-Alcohols for Tissue Selective mRNA Delivery

(2018) Piotr S. Kowalski et al.   ADVANCED MATERIALS

A Versatile, Low-Cost, Multiway Microfluidic Sorter for Droplets, Cells, and Embryos

(2018) Ramesh Utharala et al.   ANALYTICAL CHEMISTRY

Evaluation of siRNA and cationic liposomes complexes as a model for in vitro siRNA delivery to cancer cells

(2018) Ismail Eş et al.   COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

Wearable sensors: modalities, challenges, and prospects

(2018) J. Heikenfeld et al.   LAB ON A CHIP

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy

(2018) Saranya Sridhar et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

(2018) Jonathan D. Finn et al.   Cell Reports

Recent Progress in Microfluidics-Based Biosensing

(2018) Yanling Song et al.   ANALYTICAL CHEMISTRY

Systemic messenger RNA as an etiological treatment for acute intermittent porphyria

(2018) Lei Jiang et al.   NATURE MEDICINE

Recent advances in engineering microparticles and their nascent utilization in biomedical delivery and diagnostic applications

(2017) Andrew Choi et al.   LAB ON A CHIP

Progress of crystallization in microfluidic devices

(2017) Huan-huan Shi et al.   LAB ON A CHIP

pPB Peptide-Mediated siRNA-Loaded Stable Nucleic Acid Lipid Nanoparticles on Targeting Therapy of Hepatic Fibrosis

(2017) Zongxiang Jia et al.   MOLECULAR PHARMACEUTICS

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

(2017) Kapil Bahl et al.   MOLECULAR THERAPY

Core/Shell Nanocomposites Produced by Superfast Sequential Microfluidic Nanoprecipitation

(2017) Dongfei Liu et al.   NANO LETTERS

Single-step microfluidic synthesis of transferrin-conjugated lipid nanoparticles for siRNA delivery

(2017) Yujing Li et al.   Nanomedicine-Nanotechnology Biology and Medicine

Dual-functional lipid-like nanoparticles for delivery of mRNA and MRI contrast agents

(2017) X. Luo et al.   Nanoscale

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

(2017) Hao Yin et al.   NATURE BIOTECHNOLOGY

Systemic delivery of factor IX messenger RNA for protein replacement therapy

(2017) Suvasini Ramaswamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

(2017) Ding An et al.   Cell Reports

Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers

(2017) Masatoshi Maeki et al.   PLoS One

Core–Shell Chitosan Microcapsules for Programmed Sequential Drug Release

(2016) Xiu-Lan Yang et al.   ACS Applied Materials & Interfaces

Paper-Based Microfluidic Devices: Emerging Themes and Applications

(2016) Yuanyuan Yang et al.   ANALYTICAL CHEMISTRY

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA

(2016) Jason B. Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo

(2016) Kevin J. Kauffman et al.   BIOMATERIALS

Microfluidics based manufacture of liposomes simultaneously entrapping hydrophilic and lipophilic drugs

(2016) Sameer Joshi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery

(2016) Yusuke Sato et al.   JOURNAL OF CONTROLLED RELEASE

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

(2016) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo

(2016) Justin B Lee et al.   Molecular Therapy-Nucleic Acids

Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo

(2016) Genc Basha et al.   Molecular Therapy-Nucleic Acids

Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles

(2015) Srinivas Ramishetti et al.   ACS Nano

Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems

(2015) Alex K. K. Leung et al.   JOURNAL OF PHYSICAL CHEMISTRY B

An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo

(2015) Bin Li et al.   NANO LETTERS

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

High-Throughput Continuous Flow Production of Nanoscale Liposomes by Microfluidic Vertical Flow Focusing

(2015) Renee R. Hood et al.   Small

A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure

(2015) Masatoshi Maeki et al.   RSC Advances

Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration

(2014) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

A facile route to the synthesis of monodisperse nanoscale liposomes using 3D microfluidic hydrodynamic focusing in a concentric capillary array

(2014) Renee R. Hood et al.   LAB ON A CHIP

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

(2014) Varun Kumar et al.   Molecular Therapy-Nucleic Acids

Analysis of Flow and Mixing Characteristics of Planar Asymmetric Split-and-Recombine (P-SAR) Micromixers with Fan-Shaped Cavities

(2012) Guodong Xia et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation

(2012) Delai Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bottom-Up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores Using Millisecond Microfluidic Mixing

(2012) Igor V. Zhigaltsev et al.   LANGMUIR

Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

(2012) Nathan M Belliveau et al.   Molecular Therapy-Nucleic Acids

Microfluidic Mixing and the Formation of Nanoscale Lipid Vesicles

(2010) Andreas Jahn et al.   ACS Nano

Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment

(2009) Marc T Abrams et al.   MOLECULAR THERAPY