Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis

(2022) Min Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines

(2022) Janos Szebeni et al.   Nature Nanotechnology

Influence of Poly(ethylene glycol) Molecular Architecture on Particle Assembly and Ex Vivo Particle–Immune Cell Interactions in Human Blood

(2021) Jiaying Song et al.   ACS Nano

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

(2021) Linde Schoenmaker et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Reactogenicity Following Receipt of mRNA-Based COVID-19 Vaccines

(2021) Johanna Chapin-Bardales et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Potential mechanisms of anaphylaxis to COVID-19 mRNA vaccines

(2021) Kimberly A. Risma et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The dawn of mRNA vaccines: The COVID-19 case

(2021) Rein Verbeke et al.   JOURNAL OF CONTROLLED RELEASE

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

(2021) David S. Khoury et al.   NATURE MEDICINE

Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies

(2021) Bing-Mae Chen et al.   ACS Nano

From influenza to COVID-19: Lipid nanoparticle mRNA vaccines at the frontiers of infectious diseases

(2021) Emily H. Pilkington et al.   Acta Biomaterialia

Anaphylaxis associated with the mRNA COVID-19 vaccines: Approach to allergy investigation

(2021) Viktorija Erdeljic Turk   CLINICAL IMMUNOLOGY

Safety and immunogenicity of SARS-CoV-2 variant mRNA vaccine boosters in healthy adults: an interim analysis

(2021) Angela Choi et al.   NATURE MEDICINE

Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel

(2021) Yinon M. Bar-On et al.   NEW ENGLAND JOURNAL OF MEDICINE

From COVID-19 to Cancer mRNA Vaccines: Moving From Bench to Clinic in the Vaccine Landscape

(2021) Chiranjib Chakraborty et al.   Frontiers in Immunology

The role and impact of polyethylene glycol on anaphylactic reactions to COVID-19 nano-vaccines

(2021) P. Bigini et al.   Nature Nanotechnology

On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles

(2021) Sean A. Dilliard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Importance of Poly(ethylene glycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation

(2020) Thai Thanh Hoang Thi et al.   Polymers

Anti-PEG antibodies: Properties, formation, testing and role in adverse immune reactions to PEGylated nano-biopharmaceuticals

(2020) Gergely Tibor Kozma et al.   ADVANCED DRUG DELIVERY REVIEWS

PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: Faster PEG shedding attenuates anti-PEG IgM production

(2020) Takuya Suzuki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Suspicions grow that nanoparticles in Pfizer’s COVID-19 vaccine trigger rare allergic reactions

(2020) Jop Vrieze   SCIENCE

Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles

(2019) Alessia C. G. Weiss et al.   ACS Nano

Interplay of protein corona and immune cells controls blood residency of liposomes

(2019) Francesca Giulimondi et al.   Nature Communications

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

The Human In Vivo Biomolecule Corona onto PEGylated Liposomes: A Proof-of-Concept Clinical Study

(2018) Marilena Hadjidemetriou et al.   ADVANCED MATERIALS

Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles

(2018) Vivian P. Vu et al.   Nature Nanotechnology

Biological Identity of Nanoparticles In Vivo : Clinical Implications of the Protein Corona

(2017) Giulio Caracciolo et al.   TRENDS IN BIOTECHNOLOGY

Personalized protein corona on nanoparticles and its clinical implications

(2017) Claudia Corbo et al.   Biomaterials Science

Analysis of Pre-existing IgG and IgM Antibodies against Polyethylene Glycol (PEG) in the General Population

(2016) Qi Yang et al.   ANALYTICAL CHEMISTRY

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals

(2016) Bing-Mae Chen et al.   ANALYTICAL CHEMISTRY

Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation

(2016) Peng Zhang et al.   JOURNAL OF CONTROLLED RELEASE

The Mystery of Antibodies Against Polyethylene Glycol (PEG) - What do we Know?

(2016) Christian Lubich et al.   PHARMACEUTICAL RESEARCH

The nanoparticle biomolecule corona: lessons learned – challenge accepted?

(2015) D. Docter et al.   CHEMICAL SOCIETY REVIEWS

Anti-PEG immunity: emergence, characteristics, and unaddressed questions

(2015) Qi Yang et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Role of the Methoxy Group in Immune Responses to mPEG-Protein Conjugates

(2012) Merry R. Sherman et al.   BIOCONJUGATE CHEMISTRY

Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents

(2012) Ricardo P Garay et al.   Expert Opinion on Drug Delivery

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

(2011) Carl D. Walkey et al.   CHEMICAL SOCIETY REVIEWS