Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

Inhibition of hepatitis C viral RNA-dependent RNA polymerase by α-P-boranophosphate nucleotides: Exploring a potential strategy for mechanism-based HCV drug design

(2013) Marcus Adrian Cheek et al.   ANTIVIRAL RESEARCH

Cap-binding complex (CBC)

(2013) Thomas Gonatopoulos-Pournatzis et al.   BIOCHEMICAL JOURNAL

Sp-2-propylthio-ATP-α-B and Sp-2-propylthio-ATP-α-B,β-γ-dichloromethylene are novel potent and specific agonists of the human P2Y11 receptor

(2013) Michael Haas et al.   BIOCHEMICAL PHARMACOLOGY

Magnetic-Nanoparticle-Decorated Polypyrrole Microvessels: Toward Encapsulation of mRNA Cap Analogues

(2013) Krystyna Kijewska et al.   BIOMACROMOLECULES

Drug-Induced Nanocarrier Assembly as a Strategy for the Cellular Delivery of Nucleotides and Nucleotide Analogues

(2013) Giovanna Giacalone et al.   BIOMACROMOLECULES

Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding

(2013) Anna Wypijewska del Nogal et al.   FEBS Journal

Potential therapeutic applications of RNA cap analogs

(2013) Marcin Ziemniak et al.   Future Medicinal Chemistry

Treatment of Breast and Lung Cancer Cells with a N-7 Benzyl Guanosine Monophosphate Tryptamine Phosphoramidate Pronucleotide (4Ei-1) Results in Chemosensitization to Gemcitabine and Induced eIF4E Proteasomal Degradation

(2013) Shui Li et al.   MOLECULAR PHARMACEUTICS

Synthesis and hydrolytic properties of thymidine boranomonophosphate

(2013) Zhihong Xu et al.   TETRAHEDRON LETTERS

Chemical conjugation of an mRNA cap analogue with a cell-penetrating peptide as a potential membrane permeable translation inhibitor

(2013) Karolina Piecyk et al.   TETRAHEDRON LETTERS

7-Methylguanosine Diphosphate (m7GDP) Is Not Hydrolyzed but Strongly Bound by Decapping Scavenger (DcpS) Enzymes and Potently Inhibits Their Activity

(2012) Anna Wypijewska et al.   BIOCHEMISTRY

Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis

(2012) Anna M. Rydzik et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA–Cap Interaction

(2012) Xiaoqi Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reduction of metal ions by boranephosphonate DNA

(2012) Subhadeep Roy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Preparation of Synthetically Challenging Nucleotides Using Cyanoethyl P-Imidazolides and Microwaves

(2012) Malwina Strenkowska et al.   ORGANIC LETTERS

mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end

(2012) W. Su et al.   RNA

Cap in hand: Targeting eIF4E

(2011) Peter M. Fischer   CELL CYCLE

Boranophosphate Isoster Controls P2Y-Receptor Subtype Selectivity and Metabolic Stability of Dinucleoside Polyphosphate Analogues

(2011) Shir Yelovitch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Oligo(α-d-glycosyl phosphate) Derivatives by a Phosphoramidite Method via Boranophosphate Intermediates

(2011) Shoichi Fujita et al.   JOURNAL OF ORGANIC CHEMISTRY

Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH

(2011) W. Su et al.   RNA

Squalenoyl nucleoside monophosphate nanoassemblies: New prodrug strategy for the delivery of nucleotide analogues

(2010) Joachim Caron et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity

(2010) S. Kreiter et al.   CANCER RESEARCH

Targeting Eukaryotic Translation Initiation Factor 4E (eIF4E) in Cancer

(2010) A. C. Hsieh et al.   CLINICAL CANCER RESEARCH

Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies

(2010) Anna Wypijewska et al.   FEBS Journal

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

(2010) A N Kuhn et al.   GENE THERAPY

Efficient overcoming of drug resistance to anticancer nucleoside analogs by nanodelivery of active phosphorylated drugs

(2010) Carlos M. Galmarini et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Diadenosine 5′,5′′-(Boranated)polyphosphonate Analogues as Selective Nucleotide Pyrophosphatase/Phosphodiesterase Inhibitors⊥

(2010) Shay Eliahu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

(2010) Jacek Jemielity et al.   NEW JOURNAL OF CHEMISTRY

Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications

(2010) Malwina Strenkowska et al.   NEW JOURNAL OF CHEMISTRY

P1,P2-Diimidazolyl derivatives of pyrophosphate and bis-phosphonates – synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs

(2010) Ivan B. Yanachkov et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Nontoxic Chemical Interdiction of the Epithelial-to-Mesenchymal Transition by Targeting Cap-Dependent Translation

(2009) Brahma Ghosh et al.   ACS Chemical Biology

Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation

(2009) Joanna Kowalska et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

eIF4E: New Family Members, New Binding Partners, New Roles

(2009) Robert E. Rhoads   JOURNAL OF BIOLOGICAL CHEMISTRY

Drosophila miR2 Primarily Targets the m7GpppN Cap Structure for Translational Repression

(2009) Agnieszka Zdanowicz et al.   MOLECULAR CELL

Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5′,5′ bridge containing methylenebis(phosphonate) modification

(2009) Anna Maria Rydzik et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of boranoate, selenoate, and thioate analogs of AZTp4A and Ap4A

(2009) Qianwei Han et al.   TETRAHEDRON

DcpS as a Therapeutic Target for Spinal Muscular Atrophy

(2008) Jasbir Singh et al.   ACS Chemical Biology

eIF4E, the mRNA cap-binding protein: from basic discovery to translational researchThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.

(2008) Nahum Sonenberg   Biochemistry and Cell Biology

Chemical synthesis of diastereomeric diadenosine boranophosphates (ApbA) from 2′-O-(2-cyanoethoxymethyl)adenosine by the boranophosphotriester method

(2008) Yukiko Enya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

(2008) J. R. Graff et al.   CANCER RESEARCH

Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

(2008) J. Kowalska et al.   RNA