Recent Advances in Preclinical Research Using PAMAM Dendrimers for Cancer Gene Therapy

Self-Assembled Nanoparticles Prepared from Low-Molecular-Weight PEI and Low-Generation PAMAM for EGFRvIII-Chimeric Antigen Receptor Gene Loading and T-Cell Transient Modification

(2020) Qianru Yu et al.   International Journal of Nanomedicine

Nanoscale Self-Assembly for Therapeutic Delivery

(2020) Santosh Yadav et al.   Frontiers in Bioengineering and Biotechnology

Guanidyl and imidazolyl integration group‐modified PAMAM for gastric adenocarcinoma gene therapy

(2020) Dongli Wang et al.   JOURNAL OF GENE MEDICINE

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study

(2020) Jeremy S Abramson et al.   LANCET

Nanopharmaceuticals for Eye Administration: Sterilization, Depyrogenation and Clinical Applications

(2020) Aleksandra Zielińska et al.   Biology-Basel

Co-delivery of Sorafenib and CRISPR/Cas9 Based on Targeted Core–Shell Hollow Mesoporous Organosilica Nanoparticles for Synergistic HCC Therapy

(2020) Bing-Chen Zhang et al.   ACS Applied Materials & Interfaces

Nanoassemblies with Effective Serum Tolerance Capability Achieving Robust Gene Silencing Efficacy for Breast Cancer Gene Therapy

(2020) Hongmei Liu et al.   ADVANCED MATERIALS

Aptamer-Functionalized Dendrimer Delivery of Plasmid-Encoding lncRNA MEG3 Enhances Gene Therapy in Castration-Resistant Prostate Cancer

(2020) Zongguang Tai et al.   International Journal of Nanomedicine

Early Phase Clinical Immunogenicity of Valoctocogene Roxaparvovec, an AAV5-Mediated Gene Therapy for Hemophilia A

(2020) Brian R. Long et al.   MOLECULAR THERAPY

Lipodendriplexes mediated enhanced gene delivery: a cellular to pre-clinical investigation

(2020) Imran Tariq et al.   Scientific Reports

Polyplexes of Functional PAMAM Dendrimer/Apoptin Gene Induce Apoptosis of Human Primary Glioma Cells In Vitro

(2019) Yoonhee Bae et al.   Polymers

The next generation of CRISPR–Cas technologies and applications

(2019) Adrian Pickar-Oliver et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alpha-Herpesvirus Thymidine Kinase Genes Mediate Viral Virulence and Are Potential Therapeutic Targets

(2019) Ying Xie et al.   Frontiers in Microbiology

Onasemnogene Abeparvovec: First Global Approval

(2019) Sheridan M. Hoy   DRUGS

CAR T cells for brain tumors: Lessons learned and road ahead

(2019) David Akhavan et al.   IMMUNOLOGICAL REVIEWS

Aptamer-based Targeted Delivery of a G-quadruplex Ligand in Cervical Cancer Cells

(2019) Josué Carvalho et al.   Scientific Reports

A boronic acid–rich dendrimer with robust and unprecedented efficiency for cytosolic protein delivery and CRISPR-Cas9 gene editing

(2019) Chongyi Liu et al.   Science Advances

Zwitterion-functionalized dendrimer-entrapped gold nanoparticles for serum-enhanced gene delivery to inhibit cancer cell metastasis

(2019) Zhijuan Xiong et al.   Acta Biomaterialia

Co-delivery of p53 and MDM2 inhibitor RG7388 using a hydroxyl terminal PAMAM dendrimer derivative for synergistic cancer therapy

(2019) Kang Chen et al.   Acta Biomaterialia

Development and Clinical Translation of Approved Gene Therapy Products for Genetic Disorders

(2019) Alireza Shahryari et al.   Frontiers in Genetics

Co-delivery of doxorubicin and TRAIL plasmid by modified PAMAM dendrimer in colon cancer cells, in vitro and in vivo evaluation

(2019) Elham Pishavar et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Cholesterol‐conjugated PEGylated PAMAM as an Efficient Nanocarrier for Plasmid Encoding Interleukin‐12 Immunogene Delivery towards Colon Cancer Cells

(2019) Elham Pishavar et al.   BIOTECHNOLOGY PROGRESS

Multi-functional self-assembled nanoparticles for pVEGF-shRNA loading and anti-tumor targeted therapy

(2019) Sai Lu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Functionalization of Halloysite Nanotubes via Grafting of Dendrimer for Efficient Intracellular Delivery of siRNA

(2018) Zheru Long et al.   BIOCONJUGATE CHEMISTRY

RNA-Targeted Therapeutics

(2018) Stanley T. Crooke et al.   Cell Metabolism

Inhibition of cell proliferation and migration through nucleobase-modified polyamidoamine-mediated p53 delivery

(2018) Haobo Han et al.   International Journal of Nanomedicine

Hyaluronic acid-modified polyamidoamine dendrimer G5-entrapped gold nanoparticles delivering METase gene inhibits gastric tumor growth via targeting CD44+ gastric cancer cells

(2018) Yi-Fan Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Gene therapy clinical trials worldwide to 2017: An update

(2018) Samantha L. Ginn et al.   JOURNAL OF GENE MEDICINE

Clinical use of lentiviral vectors

(2018) Michael C. Milone et al.   LEUKEMIA

Dendrimers for Drug Delivery

(2018) Abhay Chauhan   MOLECULES

Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies

(2018) Zhenyi An et al.   ONCOGENE

UTMD-Promoted Co-Delivery of Gemcitabine and miR-21 Inhibitor by Dendrimer-Entrapped Gold Nanoparticles for Pancreatic Cancer Therapy

(2018) Lizhou Lin et al.   Theranostics

Intrinsic Fluorescence of PAMAM Dendrimers—Quenching Studies

(2018) Malgorzata Konopka et al.   Polymers

Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization

(2018) Susan Hua et al.   Frontiers in Pharmacology

In situ anti-cancer agent derived from [188re]rhenium nitro-imidazole ligand loaded poly-l-lysine dendrimer administrated by direct CT guided stereotactic intrahepatic injection.

(2018) Hafid Belhadj-Tahar et al.   JOURNAL OF CLINICAL ONCOLOGY

Modified PAMAM vehicles for effective TRAIL gene delivery to colon adenocarcinoma: in vitro and in vivo evaluation

(2018) Elham Pishavar et al.   Artificial Cells Nanomedicine and Biotechnology

Evaluation of cellular and transcriptional targeting of breast cancer stem cells via anti-HER2 nanobody conjugated PAMAM dendrimers

(2018) Azadeh Reshadmanesh et al.   Artificial Cells Nanomedicine and Biotechnology

Synthetic materials at the forefront of gene delivery

(2018) Irene Lostalé-Seijo et al.   Nature Reviews Chemistry

ROS-Response-Induced Zwitterionic Dendrimer for Gene Delivery

(2018) Shengran Li et al.   LANGMUIR

Aptamer-targeted delivery of Bcl-xL shRNA using alkyl modified PAMAM dendrimers into lung cancer cells

(2017) Sara Ayatollahi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

In vitro studies of phospholipid-modified PAMAM-siMDR1 complexes for the reversal of multidrug resistance in human breast cancer cells

(2017) Jing Liu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Apoptin Gene Delivery by the Functionalized Polyamidoamine Dendrimer Derivatives Induces Cell Death of U87-MG Glioblastoma Cells

(2017) Yoonhee Bae et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65 -mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial

(2017) Stephen Russell et al.   LANCET

Complex role of connexin 43 in astrocytic tumors and possible promotion of glioma-associated epileptic discharge

(2017) Hui Dong et al.   Molecular Medicine Reports

Gene Therapy for Hemophilia

(2017) Arthur W. Nienhuis et al.   MOLECULAR THERAPY

Evolving Gene Therapy in Primary Immunodeficiency

(2017) Adrian J. Thrasher et al.   MOLECULAR THERAPY

Chimeric Antigen Receptors: A Cell and Gene Therapy Perspective

(2017) Isabelle Rivière et al.   MOLECULAR THERAPY

Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy

(2017) Livia Palmerston Mendes et al.   MOLECULES

Gene Therapy in a Patient with Sickle Cell Disease

(2017) Jean-Antoine Ribeil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

Apoptin Gene Delivery by the Functionalized Polyamidoamine (PAMAM) Dendrimer Modified with Ornithine Induces Cell Death of HepG2 Cells

(2017) Yoonhee Bae et al.   Polymers

PEGylated PAMAM dendrimers: Enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery

(2016) Duy Luong et al.   Acta Biomaterialia

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

CAR-T Cell Therapy for Lymphoma

(2016) Carlos A. Ramos et al.   Annual Review of Medicine

Phenylboronic acid-functionalized polyamidoamine-mediated Bcl-2 siRNA delivery for inhibiting the cell proliferation

(2016) Di Wu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Dipeptide-functionalized polyamidoamine dendrimer-mediated apoptin gene delivery facilitates apoptosis of human primary glioma cells

(2016) Yoonhee Bae et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Reversal of multidrug resistance in breast cancer MCF-7/ADR cells by h-R3-siMDR1-PAMAM complexes

(2016) Jun Li et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Solubility enhancement and targeted delivery of a potent anticancer flavonoid analogue to cancer cells using ligand decorated dendrimer nano-architectures

(2016) Duy Luong et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

To exploit the tumor microenvironment: Since the EPR effect fails in the clinic, what is the future of nanomedicine?

(2016) F. Danhier   JOURNAL OF CONTROLLED RELEASE

A review on comparative study of PPI and PAMAM dendrimers

(2016) Daljeet Kaur et al.   JOURNAL OF NANOPARTICLE RESEARCH

Gene therapy for metachromatic leukodystrophy

(2016) Jonathan B. Rosenberg et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Chemosensitization of doxorubicin in multidrug-resistant cells by unimolecular micelles via increased cellular accumulation and apoptosis

(2016) Meng Wang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Elucidating Electrostatic Self-Assembly: Molecular Parameters as Key to Thermodynamics and Nanoparticle Shape

(2016) Giacomo Mariani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioactive cell-like hybrids coassembled from (glyco)dendrimersomes with bacterial membranes

(2016) Qi Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody h-R3-dendrimer mediated siRNA has excellent endosomal escape and tumor targeted delivery ability, and represents efficient siPLK1 silencing and inhibition of cell proliferation, migration and invasion

(2016) Jun Li et al.   Oncotarget

Expression of a gap junction protein, connexin43, in a large panel of human gliomas: new insights

(2016) Sophie Crespin et al.   Cancer Medicine

Multifunctional polyamidoamine-modified selenium nanoparticles dual-delivering siRNA and cisplatin to A549/DDP cells for reversal multidrug resistance

(2015) Wenjing Zheng et al.   Acta Biomaterialia

Combination of Nanoparticle-Delivered siRNA for Astrocyte Elevated Gene-1 (AEG-1) and All-trans Retinoic Acid (ATRA): An Effective Therapeutic Strategy for Hepatocellular Carcinoma (HCC)

(2015) Devaraja Rajasekaran et al.   BIOCONJUGATE CHEMISTRY

Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges

(2015) Lin-ping Wu et al.   BIOCONJUGATE CHEMISTRY

Supramolecular Architectures of Dendritic Amphiphiles in Water

(2015) Bala N. S. Thota et al.   CHEMICAL REVIEWS

Safety of Nanoparticles in Medicine

(2015) Joy Wolfram et al.   CURRENT DRUG TARGETS

Alipogene Tiparvovec: A Review of Its Use in Adults with Familial Lipoprotein Lipase Deficiency

(2015) Lesley J. Scott   DRUGS

Dendrimers as tunable vectors of drug delivery systems and biomedical and ocular applications

(2015) Nikos Chaniotakis et al.   International Journal of Nanomedicine

PAMAM dendrimers as promising nanocarriers for RNAi therapeutics

(2015) Prashant Kesharwani et al.   Materials Today

Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation

(2015) E. Merit Reyes-Reyes et al.   Molecular Oncology

Plasmid pORF-hTRAIL targeting to glioma using transferrin-modified polyamidoamine dendrimer

(2015) Bing Hao et al.   Drug Design Development and Therapy

RNA-Based TWIST1 Inhibition via Dendrimer Complex to Reduce Breast Cancer Cell Metastasis

(2015) James Finlay et al.   Biomed Research International

Enhanced Gene Silencing through Human Serum Albumin-Mediated Delivery of Polyethylenimine-siRNA Polyplexes

(2015) Elena Nicolì et al.   PLoS One

Surface-Engineered Dendrimers with a Diaminododecane Core Achieve Efficient Gene Transfection and Low Cytotoxicity

(2014) Hong Chang et al.   BIOCONJUGATE CHEMISTRY

Tumor targeting RGD conjugated bio-reducible polymer for VEGF siRNA expressing plasmid delivery

(2014) Hyun Ah Kim et al.   BIOMATERIALS

AAV-Mediated Gene Therapy for Atherosclerosis

(2014) Michael Lehrke et al.   Current Atherosclerosis Reports

EPR: Evidence and fallacy

(2014) Joseph W. Nichols et al.   JOURNAL OF CONTROLLED RELEASE

How to study dendrimers and dendriplexes III. Biodistribution, pharmacokinetics and toxicity in vivo

(2014) Dzmitry Shcharbin et al.   JOURNAL OF CONTROLLED RELEASE

Emerging concepts in dendrimer-based nanomedicine: from design principles to clinical applications

(2014) R. M. Kannan et al.   JOURNAL OF INTERNAL MEDICINE

Effects of Surface Displayed Targeting Ligand GE11 on Liposome Distribution and Extravasation in Tumor

(2014) Hailing Tang et al.   MOLECULAR PHARMACEUTICS

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

(2014) M. L. Davila et al.   Science Translational Medicine

Dendrimers: synthesis, applications, and properties

(2014) Elham Abbasi et al.   Nanoscale Research Letters

Therapeutic antisense oligonucleotides against cancer: hurdling to the clinic

(2014) Pedro M. D. Moreno et al.   Frontiers in Chemistry

Gene therapy on the move

(2013) Kerstin B. Kaufmann et al.   EMBO Molecular Medicine

Poly(amidoamine) dendrimer complexes as a platform for gene delivery

(2013) Dzmitry Shcharbin et al.   Expert Opinion on Drug Delivery

A novel dendritic nanocarrier of polyamidoamine-polyethylene glycol-cyclic RGD for “smart” small interfering RNA delivery and in vitro antitumor effects by human ether-à-go-go-related gene silencing in anaplastic thyroid carcinoma cells

(2013) Guanhua Li et al.   International Journal of Nanomedicine

Nonviral gene therapy in vivo with PAM-RG4/apoptin as a potential brain tumor therapeutic

(2013) Jong-Sang Park et al.   International Journal of Nanomedicine

Arginine modified PAMAM dendrimer for interferon beta gene delivery to malignant glioma

(2013) Cheng Zhe Bai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Supramolecular self-assemblies as functional nanomaterials

(2013) Eric Busseron et al.   Nanoscale

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Poly(amido amine) is an ideal carrier of miR-7 for enhancing gene silencing effects on the EGFR pathway in U251 glioma cells

(2013) XIAOZHI LIU et al.   ONCOLOGY REPORTS

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Dendrimer-entrapped gold nanoparticles modified with folic acid for targeted gene delivery applications

(2013) Tongyu Xiao et al.   Biomaterials Science

Enhanced docetaxel-mediated cytotoxicity in human prostate cancer cells through knockdown of cofilin-1 by carbon nanohorn delivered siRNA

(2012) Francisco C. Pérez-Martínez et al.   BIOMATERIALS

A review of RGD-functionalized nonviral gene delivery vectors for cancer therapy

(2012) J Park et al.   CANCER GENE THERAPY

Suicide gene therapy in cancer: Where do we stand now?

(2012) Sónia Duarte et al.   CANCER LETTERS

Surface functionalization of nanoparticles for nanomedicine

(2012) Rubul Mout et al.   CHEMICAL SOCIETY REVIEWS

Dendrimer type bio-reducible polymer for efficient gene delivery

(2012) Hye Yeong Nam et al.   JOURNAL OF CONTROLLED RELEASE

Sequence-Dependent Synergistic Inhibition of Human Glioma Cell Lines by Combined Temozolomide and miR-21 Inhibitor Gene Therapy

(2012) Xiaomin Qian et al.   MOLECULAR PHARMACEUTICS

Odyssey of a cancer nanoparticle: From injection site to site of action

(2012) Joseph W. Nichols et al.   Nano Today

In vitro and in vivo double-enhanced suicide gene therapy mediated by generation 5 polyamidoamine dendrimers for PC-3 cell line

(2012) Yue Chen et al.   World Journal of Surgical Oncology

Multifunctional Triblock Nanocarrier (PAMAM-PEG-PLL) for the Efficient Intracellular siRNA Delivery and Gene Silencing

(2011) Mahesh L. Patil et al.   ACS Nano

Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma

(2011) Shixian Huang et al.   BIOMATERIALS

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dendritic effects: dependency of dendritic nano-periodic property patterns on critical nanoscale design parameters (CNDPs)

(2011) Donald A. Tomalia   NEW JOURNAL OF CHEMISTRY

Plasmid pORF-hTRAIL and doxorubicin co-delivery targeting to tumor using peptide-conjugated polyamidoamine dendrimer

(2010) Liang Han et al.   BIOMATERIALS

Polymeric Carriers for Gene Delivery: Chitosan and Poly(amidoamine) Dendrimers

(2010) Qingxing Xu et al.   CURRENT PHARMACEUTICAL DESIGN

Nonviral gene delivery to human ovarian cancer cells using arginine-grafted PAMAM dendrimer

(2010) Soo Hyun Jang et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Dendrimer-based drug and imaging conjugates: design considerations for nanomedical applications

(2010) Anupa R. Menjoge et al.   DRUG DISCOVERY TODAY

Co-delivery of as-miR-21 and 5-FU by Poly(amidoamine) Dendrimer Attenuates Human Glioma Cell Growth in Vitro

(2010) Yu Ren et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Dendrimer-triglycine-EGF nanoparticles for tumor imaging and targeted nucleic acid and drug delivery

(2010) Quan Yuan et al.   ORAL ONCOLOGY

Nimotuzumab, an Antitumor Antibody that Targets the Epidermal Growth Factor Receptor, Blocks Ligand Binding while Permitting the Active Receptor Conformation

(2009) A. Talavera et al.   CANCER RESEARCH

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Transfection efficiencies of PAMAM dendrimers correlate inversely with their hydrophobicity

(2009) Antos Shakhbazau et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of folate-PAMAM for the delivery of antisense oligonucleotides to rat C6 glioma cellsin vitroandin vivo

(2009) Chunsheng Kang et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Mimicking PAMAM Dendrimers with Amphoteric, Hybrid Triazine Dendrimers: A Comparison of Dispersity and Stability

(2009) Sanjiv Lalwani et al.   MACROMOLECULES

Galactose-poly(ethylene glycol)-polyethylenimine for improved lung gene transfer

(2008) Jun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

5-Fluorouracil: Mechanisms of Resistance and Reversal Strategies

(2008) Ning Zhang et al.   MOLECULES