Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression

Control of RNA Stability in Immunity

(2021) Shizuo Akira et al.   Annual Review of Immunology

LARP1 and LARP4: up close with PABP for mRNA 3’ poly(A) protection and stabilization

(2021) Sandy Mattijssen et al.   RNA Biology

The Dynamics of Cytoplasmic mRNA Metabolism

(2020) Timothy J. Eisen et al.   MOLECULAR CELL

Codon and amino acid content are associated with mRNA stability in mammalian cells

(2020) Megan E. Forrest et al.   PLoS One

Viral hijacking of the TENT4–ZCCHC14 complex protects viral RNAs via mixed tailing

(2020) Dongwan Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation

(2020) Chyi-Ying A Chen et al.   RNA

The Ccr4-Not complex monitors the translating ribosome for codon optimality

(2020) Robert Buschauer et al.   SCIENCE

Pat1 increases the range of decay factors and RNA bound by the Lsm1-7 complex

(2020) Joseph H Lobel et al.   RNA

Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes

(2020) Eric J. Montemayor et al.   RNA

Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails

(2020) Sandy Mattijssen et al.   eLife

Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways

(2019) Ken Ikeuchi et al.   EMBO JOURNAL

RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not

(2019) Michael W Webster et al.   eLife

Molecular Basis for poly(A) RNP Architecture and Recognition by the Pan2-Pan3 Deadenylase

(2019) Ingmar B. Schäfer et al.   CELL

Ccr4–Not maintains genomic integrity by controlling the ubiquitylation and degradation of arrested RNAPII

(2019) Haoyang Jiang et al.   GENES & DEVELOPMENT

Quality and quantity control of gene expression by nonsense-mediated mRNA decay

(2019) Tatsuaki Kurosaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases

(2019) Terence T. L. Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylation

(2019) Tobias Raisch et al.   Nature Communications

FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control

(2019) Ivano Legnini et al.   NATURE METHODS

Coding regions affect mRNA stability in human cells

(2019) Ashrut Narula et al.   RNA

Nanopore native RNA sequencing of a human poly(A) transcriptome

(2019) Rachael E. Workman et al.   NATURE METHODS

Mechanism of ribosome stalling during translation of a poly(A) tail

(2019) Viswanathan Chandrasekaran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

mRNA structure regulates protein expression through changes in functional half-life

(2019) David M. Mauger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular choreography of pre-mRNA splicing by the spliceosome

(2019) Ruixue Wan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts

(2019) Petr Tesina et al.   EMBO JOURNAL

Unique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs

(2019) René M Arvola et al.   NUCLEIC ACIDS RESEARCH

mRNA Deadenylation Is Coupled to Translation Rates by the Differential Activities of Ccr4-Not Nucleases

(2018) Michael W. Webster et al.   MOLECULAR CELL

PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay

(2018) Hyerim Yi et al.   MOLECULAR CELL

Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation

(2018) Jaechul Lim et al.   SCIENCE

Codon choice directs constitutive mRNA levels in trypanosomes

(2018) Janaina de Freitas Nascimento et al.   eLife

Attenuated Codon Optimality Contributes to Neural-Specific mRNA Decay in Drosophila

(2018) Dana A. Burow et al.   Cell Reports

Spatial Organization of Single mRNPs at Different Stages of the Gene Expression Pathway

(2018) Srivathsan Adivarahan et al.   MOLECULAR CELL

Revisiting the Closed-Loop Model and the Nature of mRNA 5′–3′ Communication

(2018) Quentin Vicens et al.   MOLECULAR CELL

Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins

(2018) Aaron C. Goldstrohm et al.   TRENDS IN GENETICS

PARN Modulates Y RNA Stability and Its 3′-End Formation

(2017) Siddharth Shukla et al.   MOLECULAR AND CELLULAR BIOLOGY

Codon optimality, bias and usage in translation and mRNA decay

(2017) Gavin Hanson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Short poly(A) tails are a conserved feature of highly expressed genes

(2017) Sarah Azoubel Lima et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4–NOT complex to elicit repression of mRNA targets

(2017) Annamaria Sgromo et al.   RNA

Cis -regulatory elements explain most of the mRNA stability variation across genes in yeast

(2017) Jun Cheng et al.   RNA

A CAF40-binding motif facilitates recruitment of the CCR4-NOT complex to mRNAs targeted by Drosophila Roquin

(2017) Annamaria Sgromo et al.   Nature Communications

Short poly(A) tails are a conserved feature of highly expressed genes

(2017) Sarah Azoubel Lima et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Analysis of the association between codon optimality and mRNA stability in Schizosaccharomyces pombe

(2016) Yuriko Harigaya et al.   BMC GENOMICS

The RNase PARN-1 Trims piRNA 3′ Ends to Promote Transcriptome Surveillance in C. elegans

(2016) Wen Tang et al.   CELL

The DEAD-Box Protein Dhh1p Couples mRNA Decay and Translation by Monitoring Codon Optimality

(2016) Aditya Radhakrishnan et al.   CELL

Distinct modes of recruitment of the CCR4–NOT complex byDrosophilaand vertebrate Nanos

(2016) Tobias Raisch et al.   EMBO JOURNAL

Codon identity regulates mRNA stability and translation efficiency during the maternal‐to‐zygotic transition

(2016) Ariel A Bazzini et al.   EMBO JOURNAL

mTAIL-seq reveals dynamic poly(A) tail regulation in oocyte-to-embryo development

(2016) Jaechul Lim et al.   GENES & DEVELOPMENT

Connections Underlying Translation and mRNA Stability

(2016) Aditya Radhakrishnan et al.   JOURNAL OF MOLECULAR BIOLOGY

Codon Usage and 3′ UTR Length Determine Maternal mRNA Stability in Zebrafish

(2016) Yuichiro Mishima et al.   MOLECULAR CELL

The deadenylase components Not2p, Not3p, and Not5p promote mRNA decapping

(2016) Najwa Alhusaini et al.   RNA

Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1

(2016) James A.W. Stowell et al.   Cell Reports

Codon Optimality Is a Major Determinant of mRNA Stability

(2015) Vladimir Presnyak et al.   CELL

Towards a molecular understanding of microRNA-mediated gene silencing

(2015) Stefanie Jonas et al.   NATURE REVIEWS GENETICS

Global mRNA selection mechanisms for translation initiation

(2015) Joseph Costello et al.   GENOME BIOLOGY

Poly(A)-binding proteins are required for diverse biological processes in metazoans

(2014) Richard W.P. Smith et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The “tale” of poly(A) binding protein: The MLLE domain and PAM2-containing proteins

(2014) Jingwei Xie et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Global Analysis of mRNA Isoform Half-Lives Reveals Stabilizing and Destabilizing Elements in Yeast

(2014) Joseph V. Geisberg et al.   CELL

Structural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylation

(2014) J. Wolf et al.   EMBO JOURNAL

TAIL-seq: Genome-wide Determination of Poly(A) Tail Length and 3′ End Modifications

(2014) Hyeshik Chang et al.   MOLECULAR CELL

A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing

(2014) Ying Chen et al.   MOLECULAR CELL

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

(2014) Hansruedi Mathys et al.   MOLECULAR CELL

Poly(A)-tail profiling reveals an embryonic switch in translational control

(2014) Alexander O. Subtelny et al.   NATURE

The structure of the Pan2–Pan3 core complex reveals cross-talk between deadenylase and pseudokinase

(2014) Ingmar B Schäfer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay

(2014) Stefanie Jonas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Poly(A) RNA-binding proteins and polyadenosine RNA: new members and novel functions

(2014) Callie P. Wigington et al.   Wiley Interdisciplinary Reviews-RNA

The role of the E3 ligase Not4 in cotranslational quality control

(2014) Olesya O. Panasenko   Frontiers in Genetics

Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action

(2013) Seth A. Brooks et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

(2013) Latifa Zekri et al.   EMBO JOURNAL

The role of disordered protein regions in the assembly of decapping complexes and RNP granules

(2013) S. Jonas et al.   GENES & DEVELOPMENT

Structure of the PAN3 Pseudokinase Reveals the Basis for Interactions with the PAN2 Deadenylase and the GW182 Proteins

(2013) Mary Christie et al.   MOLECULAR CELL

Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin

(2013) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional Interplay between RNA-Binding Protein HuR and microRNAs

(2012) Subramanya Srikantan et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Presence of Not5 and ubiquitinated Rps7A in polysome fractions depends upon the Not4 E3 ligase

(2012) Olesya O. Panasenko et al.   MOLECULAR MICROBIOLOGY

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA

(2012) Pradipta Kundu et al.   NUCLEIC ACIDS RESEARCH

Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming

(2012) H. Berndt et al.   RNA

Drosophila Pumilio Protein Contains Multiple Autonomous Repression Domains That Regulate mRNAs Independently of Nanos and Brain Tumor

(2011) C. A. Weidmann et al.   MOLECULAR AND CELLULAR BIOLOGY

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

Tethering of Poly(A)-binding Protein Interferes with Non-translated mRNA Decay from the 5′ End in Yeast

(2010) Tatsuhisa Tsuboi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAPKAP Kinase 2 Blocks Tristetraprolin-directed mRNA Decay by Inhibiting CAF1 Deadenylase Recruitment

(2010) Francesco P. Marchese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translational control from head to tail

(2009) Rachel Groppo et al.   CURRENT OPINION IN CELL BIOLOGY

Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development

(2009) Sarah P. Blagden et al.   DEVELOPMENTAL BIOLOGY

Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

(2009) Marc R. Fabian et al.   MOLECULAR CELL

Decapping is preceded by 3′ uridylation in a novel pathway of bulk mRNA turnover

(2009) Olivia S Rissland et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The BTG2 protein is a general activator of mRNA deadenylation

(2008) Fabienne Mauxion et al.   EMBO JOURNAL

Translation factors promote the formation of two states of the closed-loop mRNP

(2008) Nadia Amrani et al.   NATURE

Multifunctional deadenylase complexes diversify mRNA control

(2008) Aaron C. Goldstrohm et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY