Role of the viral polymerase during adaptation of influenza A viruses to new hosts

Highly pathogenic avian influenza A(H5N1) virus infection in farmed minks, Spain, October 2022

(2023) Montserrat Agüero et al.   Eurosurveillance

Characterization of neurotropic HPAI H5N1 viruses with novel genome constellations and mammalian adaptive mutations in free-living mesocarnivores in Canada

(2023) Tamiru N. Alkie et al.   Emerging Microbes & Infections

BTN3A3 evasion promotes the zoonotic potential of influenza A viruses

(2023) Rute Maria Pinto et al.   NATURE

The species-specific 282 residue in the PB2 subunit of the polymerase regulates RNA synthesis and replication of influenza A viruses infecting bat and non-bat hosts.

(2022) Saptarshi Banerjee et al.   JOURNAL OF VIROLOGY

PB1 S524G mutation of wild bird-origin H3N8 influenza A virus enhances virulence and fitness for transmission in mammals

(2021) Xinghai Zhang et al.   Emerging Microbes & Infections

Avian Influenza Human Infections at the Human-Animal Interface

(2020) Damien A M Philippon et al.   JOURNAL OF INFECTIOUS DISEASES

Swine ANP32A Supports Avian Influenza Virus Polymerase

(2020) Thomas P. Peacock et al.   JOURNAL OF VIROLOGY

Key Role of the Influenza A Virus PA Gene Segment in the Emergence of Pandemic Viruses

(2020) Michael M. Lutz et al.   Viruses-Basel

Structure and Function of Influenza Polymerase

(2020) Joanna M. Wandzik et al.   Cold Spring Harbor Perspectives in Medicine

Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A

(2020) Aldo R. Camacho-Zarco et al.   Nature Communications

PA mutations inherited during viral evolution act cooperatively to increase replication of contemporary H5N1 influenza virus with an expanded host range

(2020) Yasuha Arai et al.   JOURNAL OF VIROLOGY

Eukaryotic translation elongation factor 1 delta inhibits the nuclear import of nucleoprotein and PA-PB1 heterodimer of influenza A virus

(2020) Qingxia Gao et al.   JOURNAL OF VIROLOGY

Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin

(2020) Wenjuan Du et al.   PLoS Pathogens

Multiple polymerase acidic (PA) I38X substitutions in influenza A(H1N1)pdm09 virus permit polymerase activity and cause reduced baloxavir inhibition

(2020) Jeremy C Jones et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Host ANP32A mediates the assembly of the influenza virus replicase

(2020) Loïc Carrique et al.   NATURE

Influenza virus uses transportin 1 for vRNP debundling during cell entry

(2019) Yasuyuki Miyake et al.   Nature Microbiology

Fundamental contribution and host range determination of ANP32A and ANP32B in influenza A virus polymerase activity

(2019) Haili Zhang et al.   JOURNAL OF VIROLOGY

ANP32 proteins are essential for influenza virus replication in human cells

(2019) Ecco Staller et al.   JOURNAL OF VIROLOGY

Species specific differences in use of ANP32 proteins by influenza A virus

(2019) Jason S Long et al.   eLife

Host Determinants of Influenza RNA Synthesis

(2019) Thomas P. Peacock et al.   Annual Review of Virology

Structural insight into RNA synthesis by influenza D polymerase

(2019) Qi Peng et al.   Nature Microbiology

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

(2019) Haitian Fan et al.   NATURE

Structure and Function of the Influenza Virus Transcription and Replication Machinery

(2019) Ervin Fodor et al.   Cold Spring Harbor Perspectives in Medicine

Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice

(2018) Hui Li et al.   PLoS Pathogens

Structural and Functional Motifs in Influenza Virus RNAs

(2018) Damien Ferhadian et al.   Frontiers in Microbiology

Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates

(2018) Yasuha Arai et al.   Scientific Reports

Differential Splicing of ANP32A in Birds Alters Its Ability to Stimulate RNA Synthesis by Restricted Influenza Polymerase

(2018) Steven F. Baker et al.   Cell Reports

A PB1-K577E Mutation in H9N2 Influenza Virus Increases Polymerase Activity and Pathogenicity in Mice

(2018) Haruhiko Kamiki et al.   Viruses-Basel

Novel insights into bat influenza A viruses

(2017) Kevin Ciminski et al.   JOURNAL OF GENERAL VIROLOGY

Mutations in the PA Protein of Avian H5N1 Influenza Viruses Affect Polymerase Activity and Mouse Virulence

(2017) Gongxun Zhong et al.   JOURNAL OF VIROLOGY

Structural insights into RNA synthesis by the influenza virus transcription-replication machine

(2017) Alexander Pflug et al.   VIRUS RESEARCH

Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy

(2017) Shu-Ming Kuo et al.   mBio

Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction

(2017) Patricia Domingues et al.   Cell Reports

Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and Pathogenicity

(2016) Guanlong Xu et al.   JOURNAL OF VIROLOGY

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains

(2016) Eric Thierry et al.   MOLECULAR CELL

Species difference in ANP32A underlies influenza A virus polymerase host restriction

(2016) Jason S. Long et al.   NATURE

Structural basis of an essential interaction between influenza polymerase and Pol II CTD

(2016) Maria Lukarska et al.   NATURE

Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis

(2016) Aartjan J. W. te Velthuis et al.   NATURE REVIEWS MICROBIOLOGY

Expression of importin-α isoforms in human nasal mucosa: implication for adaptation of avian influenza A viruses to human host

(2016) Khwansiri Ninpan et al.   Virology Journal

Characteristic amino acid changes of influenza A(H1N1)pdm09 virus PA protein enhance A(H7N9) viral polymerase activity

(2016) Jun Liu et al.   VIRUS GENES

The host protein CLUH participates in the subnuclear transport of influenza virus ribonucleoprotein complexes

(2016) Tomomi Ando et al.   Nature Microbiology

The role of the priming loop in influenza A virus RNA synthesis

(2016) Aartjan J. W. te Velthuis et al.   Nature Microbiology

Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus

(2016) Meng Hu et al.   Scientific Reports

Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I

(2015) Michaela Weber et al.   Cell Host & Microbe

Adaptive mutation PB2 D701N promotes nuclear import of influenza vRNPs in mammalian cells

(2015) Hanna Sediri et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice

(2015) Adriana Forero et al.   JOURNAL OF VIROLOGY

Mammalian Adaptive Mutations of the PA Protein of Highly Pathogenic Avian H5N1 Influenza Virus

(2015) Reina Yamaji et al.   JOURNAL OF VIROLOGY

Fitness Inference from Short-Read Data: Within-Host Evolution of a Reassortant H5N1 Influenza Virus

(2015) Christopher J.R. Illingworth   MOLECULAR BIOLOGY AND EVOLUTION

Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 Å Resolution

(2015) Shenghai Chang et al.   MOLECULAR CELL

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus

(2015) Narin Hengrung et al.   NATURE

Human Infection with a Novel Avian Influenza A(H5N6) Virus

(2015) Zi-Feng Yang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Determinants for Nuclear Import of Influenza A PB2 by Importin α Isoforms 3 and 7

(2015) Ruth A. Pumroy et al.   STRUCTURE

Mx GTPases: dynamin-like antiviral machines of innate immunity

(2015) Otto Haller et al.   TRENDS IN MICROBIOLOGY

pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA

(2015) Kenji Sugiyama et al.   eLife

The Nucleoprotein of Newly Emerged H7N9 Influenza A Virus Harbors a Unique Motif Conferring Resistance to Antiviral Human MxA

(2014) David Riegger et al.   JOURNAL OF VIROLOGY

Crucial role of PA in virus life cycle and host adaptation of influenza A virus

(2014) Jiao Hu et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Structural insight into cap-snatching and RNA synthesis by influenza polymerase

(2014) Stefan Reich et al.   NATURE

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

At the centre: influenza A virus ribonucleoproteins

(2014) Amie J. Eisfeld et al.   NATURE REVIEWS MICROBIOLOGY

Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus

(2014) Juan Pu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication

(2014) Wenjun Song et al.   Nature Communications

The Human Interferon-Induced MxA Protein Inhibits Early Stages of Influenza A Virus Infection by Retaining the Incoming Viral Genome in the Cytoplasm

(2013) Han Xiao et al.   JOURNAL OF VIROLOGY

PB2-588I Enhances 2009 H1N1 Pandemic Influenza Virus Virulence by Increasing Viral Replication and Exacerbating PB2 Inhibition of Beta Interferon Expression

(2013) Z. Zhao et al.   JOURNAL OF VIROLOGY

Virulence-Affecting Amino Acid Changes in the PA Protein of H7N9 Influenza A Viruses

(2013) S. Yamayoshi et al.   JOURNAL OF VIROLOGY

Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses

(2013) Di Liu et al.   LANCET

Exploration of Binary Virus–Host Interactions Using an Infectious Protein Complementation Assay

(2013) Sandie Munier et al.   MOLECULAR & CELLULAR PROTEOMICS

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

(2013) Rongbao Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Isolation and characterization of the positive-sense replicative intermediate of a negative-strand RNA virus

(2013) A. York et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleoprotein

(2013) Benjamin Mänz et al.   PLoS Pathogens

The butyrophilin (BTN) gene family: from milk fat to the regulation of the immune response

(2012) Hassnae Afrache et al.   IMMUNOGENETICS

Cellular Protein HAX1 Interacts with the Influenza A Virus PA Polymerase Subunit and Impedes Its Nuclear Translocation

(2012) W.-B. Hsu et al.   JOURNAL OF VIROLOGY

Key Molecular Factors in Hemagglutinin and PB2 Contribute to Efficient Transmission of the 2009 H1N1 Pandemic Influenza Virus

(2012) Ying Zhang et al.   JOURNAL OF VIROLOGY

Functional Balance of the Hemagglutinin and Neuraminidase Activities Accompanies the Emergence of the 2009 H1N1 Influenza Pandemic

(2012) R. Xu et al.   JOURNAL OF VIROLOGY

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

(2012) Masaki Imai et al.   NATURE

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Human-like PB2 627K Influenza Virus Polymerase Activity Is Regulated by Importin-α1 and -α7

(2012) Ben Hudjetz et al.   PLoS Pathogens

Interaction of the Influenza A Virus Polymerase PB2 C-terminal Region with Importin α Isoforms Provides Insights into Host Adaptation and Polymerase Assembly

(2011) Stephane Boivin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Viral Nucleoprotein Determines Mx Sensitivity of Influenza A Viruses

(2011) P. Zimmermann et al.   JOURNAL OF VIROLOGY

Cellular Human CLE/C14orf166 Protein Interacts with Influenza Virus Polymerase and Is Required for Viral Replication

(2011) A. Rodriguez et al.   JOURNAL OF VIROLOGY

Reassortment and Mutation of the Avian Influenza Virus Polymerase PA Subunit Overcome Species Barriers

(2011) A. Mehle et al.   JOURNAL OF VIROLOGY

The Multibasic Cleavage Site of the Hemagglutinin of Highly Pathogenic A/Vietnam/1203/2004 (H5N1) Avian Influenza Virus Acts as a Virulence Factor in a Host-Specific Manner in Mammals

(2011) A. L. Suguitan et al.   JOURNAL OF VIROLOGY

RAB11A Is Essential for Transport of the Influenza Virus Genome to the Plasma Membrane

(2011) A. J. Eisfeld et al.   JOURNAL OF VIROLOGY

Comprehensive Proteomic Analysis of Influenza Virus Polymerase Complex Reveals a Novel Association with Mitochondrial Proteins and RNA Polymerase Accessory Factors

(2011) B. G. Bradel-Tretheway et al.   JOURNAL OF VIROLOGY

PA Residues in the 2009 H1N1 Pandemic Influenza Virus Enhance Avian Influenza Virus Polymerase Activity in Mammalian Cells

(2011) K. A. Bussey et al.   JOURNAL OF VIROLOGY

Replication-Coupled and Host Factor-Mediated Encapsidation of the Influenza Virus Genome by Viral Nucleoprotein

(2011) A. Kawaguchi et al.   JOURNAL OF VIROLOGY

High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses

(2011) Y. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets

(2011) H.-L. Yen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in PA, NP, and HA of a pandemic (H1N1) 2009 influenza virus contribute to its adaptation to mice

(2011) Saori Sakabe et al.   VIRUS RESEARCH

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

(2011) Gülsah Gabriel et al.   Nature Communications

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

(2011) Franck Tarendeau et al.   PLoS Pathogens

Eurasian-Origin Gene Segments Contribute to the Transmissibility, Aerosol Release, and Morphology of the 2009 Pandemic H1N1 Influenza Virus

(2011) Seema S. Lakdawala et al.   PLoS Pathogens

RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection

(2010) Jan Rehwinkel et al.   CELL

Cellular Networks Involved in the Influenza Virus Life Cycle

(2010) Tokiko Watanabe et al.   Cell Host & Microbe

Individual influenza A virus mRNAs show differential dependence on cellular NXF1/TAP for their nuclear export

(2010) E. K. C. Read et al.   JOURNAL OF GENERAL VIROLOGY

PB2 Residue 271 Plays a Key Role in Enhanced Polymerase Activity of Influenza A Viruses in Mammalian Host Cells

(2010) K. A. Bussey et al.   JOURNAL OF VIROLOGY

PB2 Residue 158 Is a Pathogenic Determinant of Pandemic H1N1 and H5 Influenza A Viruses in Mice

(2010) B. Zhou et al.   JOURNAL OF VIROLOGY

The Rab11 Pathway Is Required for Influenza A Virus Budding and Filament Formation

(2010) E. A. Bruce et al.   JOURNAL OF VIROLOGY

The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon

(2010) K. M. Graef et al.   JOURNAL OF VIROLOGY

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

(2010) Alexander Karlas et al.   NATURE

Human importin alpha and RNA do not compete for binding to influenza A virus nucleoprotein

(2010) Sébastien Boulo et al.   VIROLOGY

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

(2010) Shinya Yamada et al.   PLoS Pathogens

A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection

(2009) Sagi D. Shapira et al.   CELL

mRNA nuclear export at a glance

(2009) S. R. Carmody et al.   JOURNAL OF CELL SCIENCE

The Polymerase Acidic Protein Gene of Influenza A Virus Contributes to Pathogenicity in a Mouse Model

(2009) M.-S. Song et al.   JOURNAL OF VIROLOGY

Selection of H5N1 Influenza Virus PB2 during Replication in Humans

(2009) Q. M. Le et al.   JOURNAL OF VIROLOGY

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

(2009) Puwei Yuan et al.   NATURE

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

(2009) Alexandre Dias et al.   NATURE

Adaptive strategies of the influenza virus polymerase for replication in humans

(2009) Andrew Mehle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Innate immune responses to influenza A H5N1: friend or foe?

(2009) Joseph Sriyal Malik Peiris et al.   TRENDS IN IMMUNOLOGY

Host Restriction of Avian Influenza Viruses at the Level of the Ribonucleoproteins

(2008) Nadia Naffakh et al.   Annual Review of Microbiology

Influenza A Virus Strains Differ in Sensitivity to the Antiviral Action of Mx-GTPase

(2008) J. Dittmann et al.   JOURNAL OF VIROLOGY

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

(2008) Eiji Obayashi et al.   NATURE

Drosophila RNAi screen identifies host genes important for influenza virus replication

(2008) Linhui Hao et al.   NATURE

The structural basis for cap binding by influenza virus polymerase subunit PB2

(2008) Delphine Guilligay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Imaging and characterizing influenza A virus mRNA transport in living cells

(2008) W. Wang et al.   NUCLEIC ACIDS RESEARCH

The Host-Dependent Interaction of α-Importins with Influenza PB2 Polymerase Subunit Is Required for Virus RNA Replication

(2008) Patricia Resa-Infante et al.   PLoS One

Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus

(2008) Gülsah Gabriel et al.   PLoS Pathogens