Key Role of the Influenza A Virus PA Gene Segment in the Emergence of Pandemic Viruses

Identification of Amino Acid Residues in Influenza A Virus PA-X That Contribute to Enhanced Shutoff Activity

(2019) Kohei Oishi et al.   Frontiers in Microbiology

Influenza virus polymerase inhibitors in clinical development

(2019) Frederick G. Hayden et al.   CURRENT OPINION IN INFECTIOUS DISEASES

The Influenza A Virus Endoribonuclease PA-X Usurps Host mRNA Processing Machinery to Limit Host Gene Expression

(2019) Lea Gaucherand et al.   Cell Reports

Scoring amino acid mutation to predict pandemic risk of avian influenza virus

(2019) Xiaoli Qiang et al.   BMC BIOINFORMATICS

Species specific differences in use of ANP32 proteins by influenza A virus

(2019) Jason S Long et al.   eLife

Structures of influenza A virus RNA polymerase offer insight into viral genome replication

(2019) Haitian Fan et al.   NATURE

Priming and realignment by the influenza a virus RdRp is dependent on the length of the host primers and the extent of base pairing to viral RNA

(2019) Corey De Vlugt et al.   VIROLOGY

Synergistic PA and HA mutations confer mouse adaptation of a contemporary A/H3N2 influenza virus

(2019) Mariana Baz et al.   Scientific Reports

Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer

(2019) Kuang-Yu Chen et al.   PLoS Pathogens

N-terminal acetylation: an essential protein modification emerges as an important regulator of stress responses

(2018) Eric Linster et al.   JOURNAL OF EXPERIMENTAL BOTANY

A Mechanism for the Activation of the Influenza Virus Transcriptase

(2018) Itziar Serna Martin et al.   MOLECULAR CELL

Identification of novel amino acid residues of influenza virus PA-X that are important for PA-X shutoff activity by using yeast

(2018) Kohei Oishi et al.   VIROLOGY

Adaptive Mutations in Influenza A/California/07/2009 Enhance Polymerase Activity and Infectious Virion Production

(2018) Patrick Slaine et al.   Viruses-Basel

Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors

(2018) Jeremy C. Jones et al.   mBio

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil

(2018) Shinya Omoto et al.   Scientific Reports

Host Interaction Analysis of PA-N155 and PA-N182 in Chicken Cells Reveals an Essential Role of UBA52 for Replication of H5N1 Avian Influenza Virus

(2018) Qiao Wang et al.   Frontiers in Microbiology

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents

(2018) Frederick G. Hayden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates

(2018) Yasuha Arai et al.   Scientific Reports

N-Terminal Acetylation by NatB Is Required for the Shutoff Activity of Influenza A Virus PA-X

(2018) Kohei Oishi et al.   Cell Reports

Host and viral determinants of influenza A virus species specificity

(2018) Jason S. Long et al.   NATURE REVIEWS MICROBIOLOGY

Insight into Influenza: A Virus Cap-Snatching

(2018) Corey De Vlugt et al.   Viruses-Basel

Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activity

(2018) Chutikarn Chaimayo et al.   PLoS Pathogens

A Mechanism for Priming and Realignment during Influenza A Virus Replication

(2017) Judith Oymans et al.   JOURNAL OF VIROLOGY

PA-X protein decreases replication and pathogenicity of swine influenza virus in cultured cells and mouse models

(2017) Xiao-Qian Gong et al.   VETERINARY MICROBIOLOGY

Influenza A virus cap-snatches host RNAs based on their abundance early after infection

(2017) Dorota Sikora et al.   VIROLOGY

Selective incorporation of vRNP into influenza A virions determined by its specific interaction with M1 protein

(2017) Chutikarn Chaimayo et al.   VIROLOGY

Structural insights into RNA synthesis by the influenza virus transcription-replication machine

(2017) Alexander Pflug et al.   VIRUS RESEARCH

Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction

(2017) Lingyan Wang et al.   Nature Communications

Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction

(2017) Patricia Domingues et al.   Cell Reports

Viral internal ribosomal entry sites: four classes for one goal

(2017) Justine Mailliot et al.   Wiley Interdisciplinary Reviews-RNA

Generation and Comprehensive Analysis of Host Cell Interactome of the PA Protein of the Highly Pathogenic H5N1 Avian Influenza Virus in Mammalian Cells

(2017) Zhao Gao et al.   Frontiers in Microbiology

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection

(2016) Nicholas S. Heaton et al.   IMMUNITY

Host cell interactome of PA protein of H5N1 influenza A virus in chicken cells

(2016) Qiao Wang et al.   Journal of Proteomics

Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and Pathogenicity

(2016) Guanlong Xu et al.   JOURNAL OF VIROLOGY

Critical Role of the PA-X C-Terminal Domain of Influenza A Virus in Its Subcellular Localization and Shutoff Activity

(2016) Tsuyoshi Hayashi et al.   JOURNAL OF VIROLOGY

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains

(2016) Eric Thierry et al.   MOLECULAR CELL

Species difference in ANP32A underlies influenza A virus polymerase host restriction

(2016) Jason S. Long et al.   NATURE

Structural basis of an essential interaction between influenza polymerase and Pol II CTD

(2016) Maria Lukarska et al.   NATURE

Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis

(2016) Aartjan J. W. te Velthuis et al.   NATURE REVIEWS MICROBIOLOGY

hCLE/C14orf166, a cellular protein required for viral replication, is incorporated into influenza virus particles

(2016) Ariel Rodriguez-Frandsen et al.   Scientific Reports

Selective Degradation of Host RNA Polymerase II Transcripts by Influenza A Virus PA-X Host Shutoff Protein

(2016) Denys A. Khaperskyy et al.   PLoS Pathogens

A systematic view on influenza induced host shutoff

(2016) Adi Bercovich-Kinori et al.   eLife

New Insight into Metal Ion-Driven Catalysis of Nucleic Acids by Influenza PA-Nter

(2016) Daria Kotlarek et al.   PLoS One

Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus

(2016) Meng Hu et al.   Scientific Reports

H5N1 influenza virulence, pathogenicity and transmissibility: what do we know?

(2015) Gabriele Neumann   Future Virology

Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity

(2015) Huijie Gao et al.   JOURNAL OF GENERAL VIROLOGY

PA-X is a virulence factor in avian H9N2 influenza virus

(2015) Huijie Gao et al.   JOURNAL OF GENERAL VIROLOGY

Mapping of a Region of the PA-X Protein of Influenza A Virus That Is Important for Its Shutoff Activity

(2015) Kohei Oishi et al.   JOURNAL OF VIROLOGY

Influenza A Virus Protein PA-X Contributes to Viral Growth and Suppression of the Host Antiviral and Immune Responses

(2015) Tsuyoshi Hayashi et al.   JOURNAL OF VIROLOGY

PA-X Decreases the Pathogenicity of Highly Pathogenic H5N1 Influenza A Virus in Avian Species by Inhibiting Virus Replication and Host Response

(2015) Jiao Hu et al.   JOURNAL OF VIROLOGY

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus

(2015) Narin Hengrung et al.   NATURE

Sequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation

(2015) David Koppstein et al.   NUCLEIC ACIDS RESEARCH

Influenza A virus preferentially snatches noncoding RNA caps

(2015) Weifeng Gu et al.   RNA

Synergistic Effect of S224P and N383D Substitutions in the PA of H5N1 Avian Influenza Virus Contributes to Mammalian Adaptation

(2015) Jiasheng Song et al.   Scientific Reports

Functions of the influenza A virus NS1 protein in antiviral defense

(2015) Robert M Krug   Current Opinion in Virology

The contribution of PA-X to the virulence of pandemic 2009 H1N1 and highly pathogenic H5N1 avian influenza viruses

(2015) Huijie Gao et al.   Scientific Reports

Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development

(2014) Tokiko Watanabe et al.   Cell Host & Microbe

PB2 Mutations D701N and S714R Promote Adaptation of an Influenza H5N1 Virus to a Mammalian Host

(2014) V. Czudai-Matwich et al.   JOURNAL OF VIROLOGY

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

Bat-derived influenza-like viruses H17N10 and H18N11

(2014) Ying Wu et al.   TRENDS IN MICROBIOLOGY

Deep sequencing reveals the eight facets of the influenza A/HongKong/1/1968 (H3N2) virus cap-snatching process

(2014) Dorota Sikora et al.   Scientific Reports

Ribosomal frameshifting used in influenza A virus expression occurs within the sequence UCC_UUU_CGU and is in the +1 direction

(2014) Firth   Open Biology

Identification of the N-Terminal Domain of the Influenza Virus PA Responsible for the Suppression of Host Protein Synthesis

(2013) E. A. Desmet et al.   JOURNAL OF VIROLOGY

Adaptation of Avian Influenza A Virus Polymerase in Mammals To Overcome the Host Species Barrier

(2013) B. Manz et al.   JOURNAL OF VIROLOGY

Virulence-Affecting Amino Acid Changes in the PA Protein of H7N9 Influenza A Viruses

(2013) S. Yamayoshi et al.   JOURNAL OF VIROLOGY

The RNA polymerase II CTD coordinates transcription and RNA processing

(2012) J.-P. Hsin et al.   GENES & DEVELOPMENT

Evolutionary Conservation of the PA-X Open Reading Frame in Segment 3 of Influenza A Virus

(2012) M. Shi et al.   JOURNAL OF VIROLOGY

Cellular Protein HAX1 Interacts with the Influenza A Virus PA Polymerase Subunit and Impedes Its Nuclear Translocation

(2012) W.-B. Hsu et al.   JOURNAL OF VIROLOGY

Identification of Novel Influenza A Virus Proteins Translated from PA mRNA

(2012) Y. Muramoto et al.   JOURNAL OF VIROLOGY

Mutations in Polymerase Genes Enhanced the Virulence of 2009 Pandemic H1N1 Influenza Virus in Mice

(2012) Wenfei Zhu et al.   PLoS One

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB

(2012) P. Van Damme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response

(2012) B. W. Jagger et al.   SCIENCE

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

(2012) Eva Kowalinski et al.   PLoS Pathogens

Repetitive prime-and-realign mechanism converts short capped RNA leaders into longer ones that may be more suitable for elongation during rice stripe virus transcription initiation

(2011) M. Yao et al.   JOURNAL OF GENERAL VIROLOGY

Cellular Human CLE/C14orf166 Protein Interacts with Influenza Virus Polymerase and Is Required for Viral Replication

(2011) A. Rodriguez et al.   JOURNAL OF VIROLOGY

Reassortment and Mutation of the Avian Influenza Virus Polymerase PA Subunit Overcome Species Barriers

(2011) A. Mehle et al.   JOURNAL OF VIROLOGY

Comprehensive Proteomic Analysis of Influenza Virus Polymerase Complex Reveals a Novel Association with Mitochondrial Proteins and RNA Polymerase Accessory Factors

(2011) B. G. Bradel-Tretheway et al.   JOURNAL OF VIROLOGY

PA Residues in the 2009 H1N1 Pandemic Influenza Virus Enhance Avian Influenza Virus Polymerase Activity in Mammalian Cells

(2011) K. A. Bussey et al.   JOURNAL OF VIROLOGY

Conventional and unconventional mechanisms for capping viral mRNA

(2011) Etienne Decroly et al.   NATURE REVIEWS MICROBIOLOGY

Regulation of Influenza RNA Polymerase Activity and the Switch between Replication and Transcription by the Concentrations of the vRNA 5′ End, the Cap Source, and the Polymerase

(2010) Andrew C. Olson et al.   BIOCHEMISTRY

Inefficient Control of Host Gene Expression by the 2009 Pandemic H1N1 Influenza A Virus NS1 Protein

(2010) B. G. Hale et al.   JOURNAL OF VIROLOGY

Evidence for Avian and Human Host Cell Factors That Affect the Activity of Influenza Virus Polymerase

(2010) O. Moncorge et al.   JOURNAL OF VIROLOGY

Complete-Proteome Mapping of Human Influenza A Adaptive Mutations: Implications for Human Transmissibility of Zoonotic Strains

(2010) Olivo Miotto et al.   PLoS One

Influenza A virus-generated small RNAs regulate the switch from transcription to replication

(2010) J. T. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome

(2009) Nicole C. Robb et al.   JOURNAL OF GENERAL VIROLOGY

The Polymerase Acidic Protein Gene of Influenza A Virus Contributes to Pathogenicity in a Mouse Model

(2009) M.-S. Song et al.   JOURNAL OF VIROLOGY

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

(2009) Puwei Yuan et al.   NATURE

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

(2009) Alexandre Dias et al.   NATURE

Adaptive strategies of the influenza virus polymerase for replication in humans

(2009) Andrew Mehle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

The multifunctional NS1 protein of influenza A viruses

(2008) B. G. Hale et al.   JOURNAL OF GENERAL VIROLOGY

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

(2008) Eiji Obayashi et al.   NATURE

The structural basis for cap binding by influenza virus polymerase subunit PB2

(2008) Delphine Guilligay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus

(2008) Gülsah Gabriel et al.   PLoS Pathogens

Structural basis for suppression of a host antiviral response by influenza A virus

(2008) K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The biology of influenza viruses

(2008) Nicole M. Bouvier et al.   VACCINE

Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding

(2007) Helena J. Maier et al.   VIROLOGY