Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus

A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase

(2016) Shuofeng Yuan et al.   Scientific Reports

Cross-Protection of Influenza A Virus Infection by a DNA Aptamer Targeting the PA Endonuclease Domain

(2015) Shuofeng Yuan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Human infection with an avian influenza A (H9N2) virus in the middle region of China

(2015) Yiwei Huang et al.   JOURNAL OF MEDICAL VIROLOGY

Dissemination, divergence and establishment of H7N9 influenza viruses in China

(2015) Tommy Tsan-Yuk Lam et al.   NATURE

Human Infection with a Novel Avian Influenza A(H5N6) Virus

(2015) Zi-Feng Yang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virus

(2015) Andrew S. Taft et al.   Nature Communications

Poultry farms as a source of avian influenza A (H7N9) virus reassortment and human infection

(2015) Donglin Wu et al.   Scientific Reports

Dual E627K and D701N mutations in the PB2 protein of A(H7N9) influenza virus increased its virulence in mammalian models

(2015) Wenfei Zhu et al.   Scientific Reports

Identification of Amino Acid Changes That May Have Been Critical for the Genesis of A(H7N9) Influenza Viruses

(2014) G. Neumann et al.   JOURNAL OF VIROLOGY

Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study

(2014) HaiYing Chen et al.   LANCET

Identification of the N-Terminal Domain of the Influenza Virus PA Responsible for the Suppression of Host Protein Synthesis

(2013) E. A. Desmet et al.   JOURNAL OF VIROLOGY

Adaptation of Avian Influenza A Virus Polymerase in Mammals To Overcome the Host Species Barrier

(2013) B. Manz et al.   JOURNAL OF VIROLOGY

Virulence-Affecting Amino Acid Changes in the PA Protein of H7N9 Influenza A Viruses

(2013) S. Yamayoshi et al.   JOURNAL OF VIROLOGY

The PA and HA Gene-Mediated High Viral Load and Intense Innate Immune Response in the Brain Contribute to the High Pathogenicity of H5N1 Avian Influenza Virus in Mallard Ducks

(2013) J. Hu et al.   JOURNAL OF VIROLOGY

The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity

(2013) B. Tefsen et al.   JOURNAL OF VIROLOGY

Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice

(2013) Jessica A. Belser et al.   NATURE

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

(2013) Rongbao Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

The PA-Gene-Mediated Lethal Dissemination and Excessive Innate Immune Response Contribute to the High Virulence of H5N1 Avian Influenza Virus in Mice

(2012) J. Hu et al.   JOURNAL OF VIROLOGY

The Hemagglutinin Protein of Highly Pathogenic H5N1 Influenza Viruses Overcomes an Early Block in the Replication Cycle To Promote Productive Replication in Macrophages

(2012) Troy D. Cline et al.   JOURNAL OF VIROLOGY

Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase

(2012) Erin Noble et al.   VIROLOGY

Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells

(2012) Benjamin Mänz et al.   Nature Communications

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

(2012) Eva Kowalinski et al.   PLoS Pathogens

Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing

(2012) Mohammed Selman et al.   Emerging Microbes & Infections

Identification of BPR3P0128 as an Inhibitor of Cap-Snatching Activities of Influenza Virus

(2011) John T.-A. Hsu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

D225G mutation in hemagglutinin of pandemic influenza H1N1 (2009) virus enhances virulence in mice

(2011) Bojian Zheng et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Virulence determinants of pandemic influenza viruses

(2011) Donna M. Tscherne et al.   JOURNAL OF CLINICAL INVESTIGATION

PA Residues in the 2009 H1N1 Pandemic Influenza Virus Enhance Avian Influenza Virus Polymerase Activity in Mammalian Cells

(2011) K. A. Bussey et al.   JOURNAL OF VIROLOGY

Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA

(2010) Eiryo Kawakami et al.   JOURNAL OF VIROLOGICAL METHODS

The PA Protein Directly Contributes to the Virulence of H5N1 Avian Influenza Viruses in Domestic Ducks

(2010) J. Song et al.   JOURNAL OF VIROLOGY

Virulence-Associated Substitution D222G in the Hemagglutinin of 2009 Pandemic Influenza A(H1N1) Virus Affects Receptor Binding

(2010) S. Chutinimitkul et al.   JOURNAL OF VIROLOGY

Mutational and Metal Binding Analysis of the Endonuclease Domain of the Influenza Virus Polymerase PA Subunit

(2010) T. Crepin et al.   JOURNAL OF VIROLOGY

Permissive Secondary Mutations Enable the Evolution of Influenza Oseltamivir Resistance

(2010) J. D. Bloom et al.   SCIENCE

Role of host-specific amino acids in the pathogenicity of avian H5N1 influenza viruses in mice

(2009) J. H. Kim et al.   JOURNAL OF GENERAL VIROLOGY

Adaptive Mutations Resulting in Enhanced Polymerase Activity Contribute to High Virulence of Influenza A Virus in Mice

(2009) T. Rolling et al.   JOURNAL OF VIROLOGY

The Polymerase Acidic Protein Gene of Influenza A Virus Contributes to Pathogenicity in a Mouse Model

(2009) M.-S. Song et al.   JOURNAL OF VIROLOGY

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

(2009) Puwei Yuan et al.   NATURE

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

(2009) Alexandre Dias et al.   NATURE

The N-Terminal Region of the PA Subunit of the RNA Polymerase of Influenza A/HongKong/156/97 (H5N1) Influences Promoter Binding

(2009) Takahito Kashiwagi et al.   PLoS One

Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus

(2008) B.-J. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

QMEAN: A comprehensive scoring function for model quality assessment

(2007) Pascal Benkert et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding

(2007) Helena J. Maier et al.   VIROLOGY