Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis

Identification of a small-molecule inhibitor of influenza virus via disrupting the subunits interaction of the viral polymerase

(2016) Shuofeng Yuan et al.   ANTIVIRAL RESEARCH

Influenza Virus and Chromatin: Role of the CHD1 Chromatin Remodeler in the Virus Life Cycle

(2016) Laura Marcos-Villar et al.   JOURNAL OF VIROLOGY

RNA-Free and Ribonucleoprotein-Associated Influenza Virus Polymerases Directly Bind the Serine-5-Phosphorylated Carboxyl-Terminal Domain of Host RNA Polymerase II

(2016) Mónica Martínez-Alonso et al.   JOURNAL OF VIROLOGY

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains

(2016) Eric Thierry et al.   MOLECULAR CELL

Species difference in ANP32A underlies influenza A virus polymerase host restriction

(2016) Jason S. Long et al.   NATURE

A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase

(2016) Shuofeng Yuan et al.   Scientific Reports

The role of the priming loop in influenza A virus RNA synthesis

(2016) Aartjan J. W. te Velthuis et al.   Nature Microbiology

Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5

(2016) Christopher Swale et al.   Scientific Reports

Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter

(2015) Piotr Gerlach et al.   CELL

Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy

(2015) Bo Liang et al.   CELL

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

(2015) Shashank Tripathi et al.   Cell Host & Microbe

Learning from structure-based drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza

(2015) Alexandre Monod et al.   Expert Opinion on Drug Discovery

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits

(2015) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication

(2015) Lorena S. Ver et al.   JOURNAL OF VIROLOGY

Identification of a Novel Viral Protein Expressed from the PB2 Segment of Influenza A Virus

(2015) Seiya Yamayoshi et al.   JOURNAL OF VIROLOGY

Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 Å Resolution

(2015) Shenghai Chang et al.   MOLECULAR CELL

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus

(2015) Narin Hengrung et al.   NATURE

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

Sequencing the cap-snatching repertoire of H1N1 influenza provides insight into the mechanism of viral transcription initiation

(2015) David Koppstein et al.   NUCLEIC ACIDS RESEARCH

Influenza A virus preferentially snatches noncoding RNA caps

(2015) Weifeng Gu et al.   RNA

Structural basis for RNA replication by the hepatitis C virus polymerase

(2015) T. C. Appleby et al.   SCIENCE

Influenza virus–host interactomes as a basis for antiviral drug development

(2015) Tokiko Watanabe et al.   Current Opinion in Virology

Phosphorylation at the Homotypic Interface Regulates Nucleoprotein Oligomerization and Assembly of the Influenza Virus Replication Machinery

(2015) Arindam Mondal et al.   PLoS Pathogens

pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA

(2015) Kenji Sugiyama et al.   eLife

Preclinical Activity of VX-787, a First-in-Class, Orally Bioavailable Inhibitor of the Influenza Virus Polymerase PB2 Subunit

(2014) Randal A. Byrn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development

(2014) Tokiko Watanabe et al.   Cell Host & Microbe

Common and unique features of viral RNA-dependent polymerases

(2014) Aartjan J. W. te Velthuis   CELLULAR AND MOLECULAR LIFE SCIENCES

Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease

(2014) Hye Yeon Sagong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2

(2014) Michael P. Clark et al.   JOURNAL OF MEDICINAL CHEMISTRY

Specific Residues of PB2 and PA Influenza Virus Polymerase Subunits Confer the Ability for RNA Polymerase II Degradation and Virus Pathogenicity in Mice

(2014) C. M. Llompart et al.   JOURNAL OF VIROLOGY

DnaJA1/Hsp40 Is Co-Opted by Influenza A Virus To Enhance Its Viral RNA Polymerase Activity

(2014) M. Cao et al.   JOURNAL OF VIROLOGY

Interactome Analysis of the Influenza A Virus Transcription/Replication Machinery Identifies Protein Phosphatase 6 as a Cellular Factor Required for Efficient Virus Replication

(2014) A. York et al.   JOURNAL OF VIROLOGY

Regulation of Influenza A Virus Nucleoprotein Oligomerization by Phosphorylation

(2014) Lauren Turrell et al.   JOURNAL OF VIROLOGY

Structural insight into cap-snatching and RNA synthesis by influenza polymerase

(2014) Stefan Reich et al.   NATURE

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

Coupling mRNA processing with transcription in time and space

(2014) David L. Bentley   NATURE REVIEWS GENETICS

Single-molecule FRET reveals a corkscrew RNA structure for the polymerase-bound influenza virus promoter

(2014) A. I. Tomescu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanisms enhancing the proteome of influenza A viruses: An overview of recently discovered proteins

(2014) A.V. Vasin et al.   VIRUS RESEARCH

Conserved and host-specific features of influenza virion architecture

(2014) Edward C. Hutchinson et al.   Nature Communications

Deep sequencing reveals the eight facets of the influenza A/HongKong/1/1968 (H3N2) virus cap-snatching process

(2014) Dorota Sikora et al.   Scientific Reports

Recruitment of RED-SMU1 Complex by Influenza A Virus RNA Polymerase to Control Viral mRNA Splicing

(2014) Guillaume Fournier et al.   PLoS Pathogens

Mechanism of Action of T-705 Ribosyl Triphosphate against Influenza Virus RNA Polymerase

(2013) Hidehiro Sangawa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High-throughput docking for the identification of new influenza A virus polymerase inhibitors targeting the PA–PB1 protein–protein interaction

(2013) Cristina Tintori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New 7-Methylguanine Derivatives Targeting the Influenza Polymerase PB2 Cap-Binding Domain

(2013) Stéphane Pautus et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isolation and characterization of the positive-sense replicative intermediate of a negative-strand RNA virus

(2013) A. York et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biogenesis, assembly, and export of viral messenger ribonucleoproteins in the influenza A virus infected cell

(2013) Ashley York et al.   RNA Biology

Transport of the Influenza Virus Genome from Nucleus to Nucleus

(2013) Edward Hutchinson et al.   Viruses-Basel

The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes

(2013) Lauren Turrell et al.   Nature Communications

The polymerase of negative-stranded RNA viruses

(2013) Benjamin Morin et al.   Current Opinion in Virology

Cellular RNA Binding Proteins NS1-BP and hnRNP K Regulate Influenza A Virus RNA Splicing

(2013) Pei-Ling Tsai et al.   PLoS Pathogens

Monomeric Nucleoprotein of Influenza A Virus

(2013) Sylvie Chenavas et al.   PLoS Pathogens

A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly

(2012) Chunfeng Li et al.   FEBS Journal

A Small-RNA Enhancer of Viral Polymerase Activity

(2012) J. T. Perez et al.   JOURNAL OF VIROLOGY

Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase

(2012) G. Muratore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of Native Influenza Virion Ribonucleoproteins

(2012) R. Arranz et al.   SCIENCE

Organization of the Influenza Virus Replication Machinery

(2012) A. Moeller et al.   SCIENCE

Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells

(2012) Benjamin Mänz et al.   Nature Communications

Emerging Roles for the Influenza A Virus Nuclear Export Protein (NEP)

(2012) Duncan Paterson et al.   PLoS Pathogens

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

(2012) Rebecca M. DuBois et al.   PLoS Pathogens

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

(2012) Eva Kowalinski et al.   PLoS Pathogens

CHD6 chromatin remodeler is a negative modulator of influenza virus replication that relocates to inactive chromatin upon infection

(2011) Roberto Alfonso et al.   CELLULAR MICROBIOLOGY

Characterization of the interaction between the influenza A virus polymerase subunit PB1 and the host nuclear import factor Ran-binding protein 5

(2011) E. C. Hutchinson et al.   JOURNAL OF GENERAL VIROLOGY

The accumulation of influenza A virus segment 7 spliced mRNAs is regulated by the NS1 protein

(2011) N. C. Robb et al.   JOURNAL OF GENERAL VIROLOGY

Cellular cap-binding proteins associate with influenza virus mRNAs

(2011) K. Bier et al.   JOURNAL OF GENERAL VIROLOGY

Cellular Human CLE/C14orf166 Protein Interacts with Influenza Virus Polymerase and Is Required for Viral Replication

(2011) A. Rodriguez et al.   JOURNAL OF VIROLOGY

Comprehensive Proteomic Analysis of Influenza Virus Polymerase Complex Reveals a Novel Association with Mitochondrial Proteins and RNA Polymerase Accessory Factors

(2011) B. G. Bradel-Tretheway et al.   JOURNAL OF VIROLOGY

The Influenza A Virus NS1 Protein Interacts with the Nucleoprotein of Viral Ribonucleoprotein Complexes

(2011) N. C. Robb et al.   JOURNAL OF VIROLOGY

Replication-Coupled and Host Factor-Mediated Encapsidation of the Influenza Virus Genome by Viral Nucleoprotein

(2011) A. Kawaguchi et al.   JOURNAL OF VIROLOGY

The influenza virus RNA synthesis machine

(2011) Patricia Resa-Infante et al.   RNA Biology

Host- and Strain-Specific Regulation of Influenza Virus Polymerase Activity by Interacting Cellular Proteins

(2011) E. Bortz et al.   mBio

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

(2011) Franck Tarendeau et al.   PLoS Pathogens

The Splicing Factor Proline-Glutamine Rich (SFPQ/PSF) Is Involved in Influenza Virus Transcription

(2011) Sara Landeras-Bueno et al.   PLoS Pathogens

Influenza Virus Ribonucleoprotein Complexes Gain Preferential Access to Cellular Export Machinery through Chromatin Targeting

(2011) Geoffrey P. Chase et al.   PLoS Pathogens

Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase

(2010) Kerstin Wunderlich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Antiviral Activity of Favipiravir (T-705) against Drug-Resistant Influenza and 2009 A(H1N1) Viruses

(2010) K. Sleeman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Disruption of the Viral Polymerase Complex Assembly as a Novel Approach to Attenuate Influenza A Virus

(2010) Benjamin Mänz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Analysis of the Influenza Virus H5N1 Nucleoprotein Tail Loop Reveals Amino Acids That Are Crucial for Oligomerization and Ribonucleoprotein Activities

(2010) W.-H. Chan et al.   JOURNAL OF VIROLOGY

Structural and Functional Characterization of an Influenza Virus RNA Polymerase-Genomic RNA Complex

(2010) Patricia Resa-Infante et al.   JOURNAL OF VIROLOGY

Association of the Influenza Virus RNA Polymerase Subunit PB2 with the Host Chaperonin CCT

(2010) T. Fislova et al.   JOURNAL OF VIROLOGY

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication

(2010) Alexander Karlas et al.   NATURE

Influenza A virus-generated small RNAs regulate the switch from transcription to replication

(2010) J. T. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human importin alpha and RNA do not compete for binding to influenza A virus nucleoprotein

(2010) Sébastien Boulo et al.   VIROLOGY

Influenza A Virus Expresses High Levels of an Unusual Class of Small Viral Leader RNAs in Infected Cells

(2010) J. L. Umbach et al.   mBio

The role of the influenza virus RNA polymerase in host shut-off

(2010) Frank T. Vreede et al.   Virulence

A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection

(2009) Sagi D. Shapira et al.   CELL

The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

(2009) Abraham L. Brass et al.   CELL

Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase

(2009) Kanako Sugiyama et al.   EMBO JOURNAL

NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome

(2009) Nicole C. Robb et al.   JOURNAL OF GENERAL VIROLOGY

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

(2009) Puwei Yuan et al.   NATURE

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

(2009) Alexandre Dias et al.   NATURE

Human host factors required for influenza virus replication

(2009) Renate König et al.   NATURE

The use of Random Homozygous Gene Perturbation to identify novel host-oriented targets for influenza

(2009) Baoquan Sui et al.   VIROLOGY

Mechanisms and functional implications of the degradation of host RNA polymerase II in influenza virus infected cells

(2009) Frank T. Vreede et al.   VIROLOGY

Genetic trans-Complementation Establishes a New Model for Influenza Virus RNA Transcription and Replication

(2009) Núria Jorba et al.   PLoS Pathogens

Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design

(2008) Andy Ka-Leung Ng et al.   FASEB JOURNAL

Oligomerization of the influenza virus polymerase complex in vivo

(2008) N. Jorba et al.   JOURNAL OF GENERAL VIROLOGY

Interaction of the Influenza A Virus Nucleocapsid Protein with the Viral RNA Polymerase Potentiates Unprimed Viral RNA Replication

(2008) L. L. Newcomb et al.   JOURNAL OF VIROLOGY

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

(2008) Eiji Obayashi et al.   NATURE

Drosophila RNAi screen identifies host genes important for influenza virus replication

(2008) Linhui Hao et al.   NATURE

The structural basis for cap binding by influenza virus polymerase subunit PB2

(2008) Delphine Guilligay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Host-Dependent Interaction of α-Importins with Influenza PB2 Polymerase Subunit Is Required for Virus RNA Replication

(2008) Patricia Resa-Infante et al.   PLoS One

Analysis of the interaction of influenza virus polymerase complex with human cell factors

(2008) Núria Jorba et al.   PROTEOMICS