Multiple polymerase acidic (PA) I38X substitutions in influenza A(H1N1)pdm09 virus permit polymerase activity and cause reduced baloxavir inhibition

A rapid pyrosequencing assay for the molecular detection of influenza viruses with reduced baloxavir susceptibility due to PA/I38X amino acid substitutions

(2020) Paulina Koszalka et al.   Influenza and Other Respiratory Viruses

Rapid detection of an I38T amino acid substitution in influenza polymerase acidic subunit associated with reduced susceptibility to baloxavir marboxil

(2020) Mina Nakauchi et al.   Influenza and Other Respiratory Viruses

Influenza Polymerase Inhibitors: Mechanisms of Action and Resistance

(2020) Emi Takashita   Cold Spring Harbor Perspectives in Medicine

Influenza A and B viruses with reduced baloxavir susceptibility display attenuated in vitro fitness but retain ferret transmissibility

(2020) Jeremy C. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive assessment of amino acid substitutions in the trimeric RNA polymerase complex of influenza A virus detected in clinical trials of baloxavir marboxil

(2020) Takashi Hashimoto et al.   Influenza and Other Respiratory Viruses

Baloxavir marboxil in Japanese patients with seasonal influenza: Dose response and virus type/subtype outcomes from a randomized phase 2 study

(2019) Akira Watanabe et al.   ANTIVIRAL RESEARCH

Comprehensive mapping of adaptation of the avian influenza polymerase protein PB2 to humans

(2019) YQ Shirleen Soh et al.   eLife

Impact of the Baloxavir-Resistant Polymerase Acid I38T Substitution on the Fitness of Contemporary Influenza A(H1N1)pdm09 and A(H3N2) Strains

(2019) Liva Checkmahomed et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonuclease acquires resistance against Baloxavir marboxil

(2019) Ryunosuke Yoshino et al.   Scientific Reports

Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

(2019) Masaki Imai et al.   Nature Microbiology

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil

(2018) Shinya Omoto et al.   Scientific Reports

Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents

(2018) Frederick G. Hayden et al.   NEW ENGLAND JOURNAL OF MEDICINE

A novel twelve class fluctuation test reveals higher than expected mutation rates for influenza A viruses

(2017) Matthew D Pauly et al.   eLife

Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor

(2016) Min-Suk Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational Analysis of the Binding Pockets of the Diketo Acid Inhibitor L-742,001 in the Influenza Virus PA Endonuclease

(2013) A. Stevaert et al.   JOURNAL OF VIROLOGY

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

(2012) Eva Kowalinski et al.   PLoS Pathogens