Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

(2011) Franck Tarendeau et al.   PLoS Pathogens

Introduction of Virulence Markers in PB2 of Pandemic Swine-Origin Influenza Virus Does Not Result in Enhanced Virulence or Transmission

(2010) S. Herfst et al.   JOURNAL OF VIROLOGY

Substitution of lysine at 627 position in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice

(2010) Huachen Zhu et al.   VIROLOGY

Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer

(2009) Amy Raymond et al.   BMC BIOTECHNOLOGY

Gene Composer: database software for protein construct design, codon engineering, and gene synthesis

(2009) Don Lorimer et al.   BMC BIOTECHNOLOGY

Structural Basis of the Influenza A Virus RNA Polymerase PB2 RNA-binding Domain Containing the Pathogenicity-determinant Lysine 627 Residue

(2009) Takashi Kuzuhara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ostrich Involvement in the Selection of H5N1 Influenza Virus Possessing Mammalian-Type Amino Acids in the PB2 Protein

(2009) K. Shinya et al.   JOURNAL OF VIROLOGY

Selection of H5N1 Influenza Virus PB2 during Replication in Humans

(2009) Q. M. Le et al.   JOURNAL OF VIROLOGY

Emergence and pandemic potential of swine-origin H1N1 influenza virus

(2009) Gabriele Neumann et al.   NATURE

Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air

(2009) N. Van Hoeven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N

(2009) John Steel et al.   PLoS Pathogens

An Inhibitory Activity in Human Cells Restricts the Function of an Avian-like Influenza Virus Polymerase

(2008) Andrew Mehle et al.   Cell Host & Microbe

Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread

(2008) H.-L. Yen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining the polymerase incomplete primer extension method for cloning and mutagenesis with microscreening to accelerate structural genomics efforts

(2007) Heath E. Klock et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS