Characterization of neurotropic HPAI H5N1 viruses with novel genome constellations and mammalian adaptive mutations in free-living mesocarnivores in Canada

Highly pathogenic avian influenza is an emerging disease threat to wild birds in North America

(2022) Andrew M. Ramey et al.   JOURNAL OF WILDLIFE MANAGEMENT

Infections with highly pathogenic avian influenza A virus (HPAIV) H5N8 in harbor seals at the German North Sea coast, 2021

(2022) Alexander Postel et al.   Emerging Microbes & Infections

Transatlantic spread of highly pathogenic avian influenza H5N1 by wild birds from Europe to North America in 2021

(2022) V. Caliendo et al.   Scientific Reports

Dynamic PB2-E627K substitution of influenza H7N9 virus indicates the in vivo genetic tuning and rapid host adaptation

(2020) William J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BEAST 2.5: An advanced software platform for Bayesian evolutionary analysis

(2019) Remco Bouckaert et al.   PLoS Computational Biology

A brief history of bird flu

(2019) Samantha J. Lycett et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammals

(2019) Yasuha Arai et al.   PLoS Pathogens

Human Clade 2.3.4.4 A/H5N6 Influenza Virus Lacks Mammalian Adaptation Markers and Does Not Transmit via the Airborne Route between Ferrets

(2018) Sander Herfst et al.   mSphere

Identification of polymerase gene mutations that affect viral replication in H5N1 influenza viruses isolated from pigeons

(2017) Emad Mohamed Elgendy et al.   JOURNAL OF GENERAL VIROLOGY

Characterization of H5N1 highly pathogenic mink influenza viruses in eastern China

(2017) Wenming Jiang et al.   VETERINARY MICROBIOLOGY

Use of Sequence-Independent, Single-Primer-Amplification (SISPA) for rapid detection, identification, and characterization of avian RNA viruses

(2017) Klaudia Chrzastek et al.   VIROLOGY

Highly Pathogenic Avian Influenza H5N6 Viruses Exhibit Enhanced Affinity for Human Type Sialic Acid Receptor and In-Contact Transmission in Model Ferrets

(2016) Honglei Sun et al.   JOURNAL OF VIROLOGY

Fatal influenza A (H5N1) virus Infection in zoo-housed Tigers in Yunnan Province, China

(2016) Tingsong Hu et al.   Scientific Reports

Surveillance for highly pathogenic H5 avian influenza virus in synanthropic wildlife associated with poultry farms during an acute outbreak

(2016) Susan A. Shriner et al.   Scientific Reports

Influenza Virus Adaptation PB2-627K Modulates Nucleocapsid Inhibition by the Pathogen Sensor RIG-I

(2015) Michaela Weber et al.   Cell Host & Microbe

Large-Scale Conformational Dynamics Control H5N1 Influenza Polymerase PB2 Binding to Importin α

(2015) Elise Delaforge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transmission of H7N9 Influenza Viruses with a Polymorphism at PB2 Residue 627 in Chickens and Ferrets

(2015) Geraldine S. M. Luk et al.   JOURNAL OF VIROLOGY

Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice

(2015) Xiaoxiao Feng et al.   JOURNAL OF VIROLOGY

Intercontinental Spread of Asian-Origin H5N8 to North America through Beringia by Migratory Birds

(2015) Dong-Hun Lee et al.   JOURNAL OF VIROLOGY

Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virus

(2015) Andrew S. Taft et al.   Nature Communications

Reassortant Highly Pathogenic Influenza A H5N2 Virus Containing Gene Segments Related to Eurasian H5N8 in British Columbia, Canada, 2014

(2015) John Pasick et al.   Scientific Reports

Amino Acid Substitutions in Polymerase Basic Protein 2 Gene Contribute to the Pathogenicity of the Novel A/H7N9 Influenza Virus in Mammalian Hosts

(2014) C. K. P. Mok et al.   JOURNAL OF VIROLOGY

Virulence-Affecting Amino Acid Changes in the PA Protein of H7N9 Influenza A Viruses

(2013) S. Yamayoshi et al.   JOURNAL OF VIROLOGY

Adaptive mutations in the H5N1 polymerase complex

(2013) Gülsah Gabriel et al.   VIRUS RESEARCH

Interaction of the Influenza A Virus Polymerase PB2 C-terminal Region with Importin α Isoforms Provides Insights into Host Adaptation and Polymerase Assembly

(2011) Stephane Boivin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Impact of the Host Adaptation-associated PB2 E627K Mutation on the Temperature-dependent RNA Synthesis Kinetics of Influenza A Virus Polymerase Complex

(2011) Shilpa Aggarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antigenic Drift in H5N1 Avian Influenza Virus in Poultry Is Driven by Mutations in Major Antigenic Sites of the Hemagglutinin Molecule Analogous to Those for Human Influenza Virus

(2011) G. Cattoli et al.   JOURNAL OF VIROLOGY

PB2 Residue 271 Plays a Key Role in Enhanced Polymerase Activity of Influenza A Viruses in Mammalian Host Cells

(2010) K. A. Bussey et al.   JOURNAL OF VIROLOGY

In Vitro Assessment of Attachment Pattern and Replication Efficiency of H5N1 Influenza A Viruses with Altered Receptor Specificity

(2010) S. Chutinimitkul et al.   JOURNAL OF VIROLOGY

Production and diagnostic application of monoclonal antibodies against influenza virus H5

(2009) Ming Yang et al.   JOURNAL OF VIROLOGICAL METHODS

Genetic and Pathobiologic Characterization of Pandemic H1N1 2009 Influenza Viruses from a Naturally Infected Swine Herd

(2009) H. M. Weingartl et al.   JOURNAL OF VIROLOGY

Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2

(2009) Junwei Li et al.   VIRUS RESEARCH

Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N

(2009) John Steel et al.   PLoS Pathogens

The Host-Dependent Interaction of α-Importins with Influenza PB2 Polymerase Subunit Is Required for Virus RNA Replication

(2008) Patricia Resa-Infante et al.   PLoS One

Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus

(2008) Gülsah Gabriel et al.   PLoS Pathogens

The biology of influenza viruses

(2008) Nicole M. Bouvier et al.   VACCINE

Development and application of monoclonal antibodies against avian influenza virus nucleoprotein

(2007) Ming Yang et al.   JOURNAL OF VIROLOGICAL METHODS