Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates

Identification of polymerase gene mutations that affect viral replication in H5N1 influenza viruses isolated from pigeons

(2017) Emad Mohamed Elgendy et al.   JOURNAL OF GENERAL VIROLOGY

Five distinct reassortants of H5N6 highly pathogenic avian influenza A viruses affected Japan during the winter of 2016–2017

(2017) Nobuhiro Takemae et al.   VIROLOGY

Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China

(2016) Yuhai Bi et al.   Cell Host & Microbe

Multiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human Cells

(2016) Benjamin Mänz et al.   JOURNAL OF VIROLOGY

Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and Pathogenicity

(2016) Guanlong Xu et al.   JOURNAL OF VIROLOGY

Shifting Clade Distribution, Reassortment, and Emergence of New Subtypes of Highly Pathogenic Avian Influenza A(H5) Viruses Collected from Vietnamese Poultry from 2012 to 2015

(2016) Diep T. Nguyen et al.   JOURNAL OF VIROLOGY

Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses

(2016) Yasuha Arai et al.   PLoS Pathogens

Novel Highly Pathogenic Avian A(H5N2) and A(H5N8) Influenza Viruses of Clade 2.3.4.4 from North America Have Limited Capacity for Replication and Transmission in Mammals

(2016) Bryan S. Kaplan et al.   mSphere

Genetic evolution of H5 highly pathogenic avian influenza virus in domestic poultry in Vietnam between 2011 and 2013

(2015) Eun-Kyoung Lee et al.   POULTRY SCIENCE

Characterization of H5N1 Influenza Virus Variants with Hemagglutinin Mutations Isolated from Patients

(2015) Yohei Watanabe et al.   mBio

Viral determinants of influenza A virus host range

(2014) A. V. Cauldwell et al.   JOURNAL OF GENERAL VIROLOGY

PB2 Mutations D701N and S714R Promote Adaptation of an Influenza H5N1 Virus to a Mammalian Host

(2014) V. Czudai-Matwich et al.   JOURNAL OF VIROLOGY

Structural insight into cap-snatching and RNA synthesis by influenza polymerase

(2014) Stefan Reich et al.   NATURE

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

At the centre: influenza A virus ribonucleoproteins

(2014) Amie J. Eisfeld et al.   NATURE REVIEWS MICROBIOLOGY

Avian influenza H5N1 viral and bird migration networks in Asia

(2014) Huaiyu Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmission of influenza A/H5N1 viruses in mammals

(2013) M. Imai et al.   VIRUS RESEARCH

The emergence and diversification of panzootic H5N1 influenza viruses

(2013) Yi Guan et al.   VIRUS RESEARCH

Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells

(2012) Benjamin Mänz et al.   Nature Communications

The role of receptor binding specificity in interspecies transmission of influenza viruses

(2012) Masaki Imai et al.   Current Opinion in Virology

Human-like PB2 627K Influenza Virus Polymerase Activity Is Regulated by Importin-α1 and -α7

(2012) Ben Hudjetz et al.   PLoS Pathogens

Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing

(2012) Mohammed Selman et al.   Emerging Microbes & Infections

Genetic diversification of H5N1 highly pathogenic avian influenza A virus during replication in wild ducks

(2011) Y. Watanabe et al.   JOURNAL OF GENERAL VIROLOGY

Indications that Live Poultry Markets Are a Major Source of Human H5N1 Influenza Virus Infection in China

(2011) X.-F. Wan et al.   JOURNAL OF VIROLOGY

The changing nature of avian influenza A virus (H5N1)

(2011) Yohei Watanabe et al.   TRENDS IN MICROBIOLOGY

Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus

(2011) Gülsah Gabriel et al.   Nature Communications

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

(2011) Franck Tarendeau et al.   PLoS Pathogens

Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt

(2011) Yohei Watanabe et al.   PLoS Pathogens

PB2 Residue 158 Is a Pathogenic Determinant of Pandemic H1N1 and H5 Influenza A Viruses in Mice

(2010) B. Zhou et al.   JOURNAL OF VIROLOGY

Biological and Structural Characterization of a Host-Adapting Amino Acid in Influenza Virus

(2010) Shinya Yamada et al.   PLoS Pathogens

Molecular Determinants of Adaptation of Highly Pathogenic Avian Influenza H7N7 Viruses to Efficient Replication in the Human Host

(2009) E. de Wit et al.   JOURNAL OF VIROLOGY

Transmission of Influenza Virus in a Mammalian Host Is Increased by PB2 Amino Acids 627K or 627E/701N

(2009) John Steel et al.   PLoS Pathogens

Host Restriction of Avian Influenza Viruses at the Level of the Ribonucleoproteins

(2008) Nadia Naffakh et al.   Annual Review of Microbiology

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE

The structural basis for cap binding by influenza virus polymerase subunit PB2

(2008) Delphine Guilligay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY