Crucial role of PA in virus life cycle and host adaptation of influenza A virus

Specific Residues of PB2 and PA Influenza Virus Polymerase Subunits Confer the Ability for RNA Polymerase II Degradation and Virus Pathogenicity in Mice

(2014) C. M. Llompart et al.   JOURNAL OF VIROLOGY

Mechanism of Action of T-705 Ribosyl Triphosphate against Influenza Virus RNA Polymerase

(2013) Hidehiro Sangawa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High-throughput docking for the identification of new influenza A virus polymerase inhibitors targeting the PA–PB1 protein–protein interaction

(2013) Cristina Tintori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China

(2013) Aiping Wu et al.   Cell Host & Microbe

Co-incorporation of the PB2 and PA polymerase subunits from human H3N2 influenza virus is a critical determinant of the replication of reassortant ribonucleoprotein complexes

(2013) K. Hara et al.   JOURNAL OF GENERAL VIROLOGY

Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility

(2013) H. Shelton et al.   JOURNAL OF GENERAL VIROLOGY

Caspase-1 Deficient Mice Are More Susceptible to Influenza A Virus Infection With PA Variation

(2013) C.-H. Huang et al.   JOURNAL OF INFECTIOUS DISEASES

New Virulence Determinants Contribute to the Enhanced Immune Response and Reduced Virulence of an Influenza A Virus A/PR8/34 Variant

(2013) Swantje Liedmann et al.   JOURNAL OF INFECTIOUS DISEASES

Identification of the N-Terminal Domain of the Influenza Virus PA Responsible for the Suppression of Host Protein Synthesis

(2013) E. A. Desmet et al.   JOURNAL OF VIROLOGY

Adaptation of Avian Influenza A Virus Polymerase in Mammals To Overcome the Host Species Barrier

(2013) B. Manz et al.   JOURNAL OF VIROLOGY

The PA and HA Gene-Mediated High Viral Load and Intense Innate Immune Response in the Brain Contribute to the High Pathogenicity of H5N1 Avian Influenza Virus in Mallard Ducks

(2013) J. Hu et al.   JOURNAL OF VIROLOGY

Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage

(2013) Kausiki Datta et al.   NUCLEIC ACIDS RESEARCH

The PB2, PA, HA, NP, and NS genes of a highly pathogenic avian influenza virus A/whooper swan/Mongolia/3/2005 (H5N1) are responsible for pathogenicity in ducks

(2013) Masahiro Kajihara et al.   Virology Journal

Differences in Cytokine Production in Human Macrophages and in Virulence in Mice Are Attributable to the Acidic Polymerase Protein of Highly Pathogenic Influenza A Virus Subtype H5N1

(2012) Saori Sakabe et al.   JOURNAL OF INFECTIOUS DISEASES

The Influenza A Virus PB2, PA, NP, and M Segments Play a Pivotal Role during Genome Packaging

(2012) Q. Gao et al.   JOURNAL OF VIROLOGY

A Small-RNA Enhancer of Viral Polymerase Activity

(2012) J. T. Perez et al.   JOURNAL OF VIROLOGY

Cellular Protein HAX1 Interacts with the Influenza A Virus PA Polymerase Subunit and Impedes Its Nuclear Translocation

(2012) W.-B. Hsu et al.   JOURNAL OF VIROLOGY

The PA-Gene-Mediated Lethal Dissemination and Excessive Innate Immune Response Contribute to the High Virulence of H5N1 Avian Influenza Virus in Mice

(2012) J. Hu et al.   JOURNAL OF VIROLOGY

Identification of Novel Influenza A Virus Proteins Translated from PA mRNA

(2012) Y. Muramoto et al.   JOURNAL OF VIROLOGY

Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential

(2012) Zsuzsanna T. Varga et al.   JOURNAL OF VIROLOGY

Mutations in Polymerase Genes Enhanced the Virulence of 2009 Pandemic H1N1 Influenza Virus in Mice

(2012) Wenfei Zhu et al.   PLoS One

An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response

(2012) B. W. Jagger et al.   SCIENCE

Adaptive mutations in NEP compensate for defective H5N1 RNA replication in cultured human cells

(2012) Benjamin Mänz et al.   Nature Communications

Identification of a Novel Splice Variant Form of the Influenza A Virus M2 Ion Channel with an Antigenically Distinct Ectodomain

(2012) Helen M. Wise et al.   PLoS Pathogens

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

(2012) Rebecca M. DuBois et al.   PLoS Pathogens

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

(2012) Eva Kowalinski et al.   PLoS Pathogens

Adaptive mutation in influenza A virus non-structural gene is linked to host switching and induces a novel protein by alternative splicing

(2012) Mohammed Selman et al.   Emerging Microbes & Infections

In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections

(2011) Yohichi Kumaki et al.   ANTIVIRAL RESEARCH

HAX-1: A family of apoptotic regulators in health and disease

(2011) Solomon V. Yap et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Synergistic Adaptive Mutations in the Hemagglutinin and Polymerase Acidic Protein Lead to Increased Virulence of Pandemic 2009 H1N1 Influenza A Virus in Mice

(2011) Roman Seyer et al.   JOURNAL OF INFECTIOUS DISEASES

Cellular Human CLE/C14orf166 Protein Interacts with Influenza Virus Polymerase and Is Required for Viral Replication

(2011) A. Rodriguez et al.   JOURNAL OF VIROLOGY

Emergence of Mammalian Species-Infectious and -Pathogenic Avian Influenza H6N5 Virus with No Evidence of Adaptation

(2011) J.-H. Nam et al.   JOURNAL OF VIROLOGY

Reassortment and Mutation of the Avian Influenza Virus Polymerase PA Subunit Overcome Species Barriers

(2011) A. Mehle et al.   JOURNAL OF VIROLOGY

Comprehensive Proteomic Analysis of Influenza Virus Polymerase Complex Reveals a Novel Association with Mitochondrial Proteins and RNA Polymerase Accessory Factors

(2011) B. G. Bradel-Tretheway et al.   JOURNAL OF VIROLOGY

High genetic compatibility and increased pathogenicity of reassortants derived from avian H9N2 and pandemic H1N1/2009 influenza viruses

(2011) Y. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in PA, NP, and HA of a pandemic (H1N1) 2009 influenza virus contribute to its adaptation to mice

(2011) Saori Sakabe et al.   VIRUS RESEARCH

Differential Contribution of PB1-F2 to the Virulence of Highly Pathogenic H5N1 Influenza A Virus in Mammalian and Avian Species

(2011) Mirco Schmolke et al.   PLoS Pathogens

The Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon at the Level of the MAVS Adaptor Protein

(2011) Zsuzsanna T. Varga et al.   PLoS Pathogens

Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase

(2010) Kerstin Wunderlich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Three amino acid changes in PB1-F2 of highly pathogenic H5N1 avian influenza virus affect pathogenicity in mallard ducks

(2010) Henju Marjuki et al.   ARCHIVES OF VIROLOGY

Towards an atomic resolution understanding of the influenza virus replication machinery

(2010) Rob WH Ruigrok et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Internal Initiation of Influenza Virus Replication of Viral RNA and Complementary RNAin Vitro

(2010) Shijian Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PA Protein Directly Contributes to the Virulence of H5N1 Avian Influenza Viruses in Domestic Ducks

(2010) J. Song et al.   JOURNAL OF VIROLOGY

Adaptation of Pandemic H1N1 Influenza Viruses in Mice

(2010) N. A. Ilyushina et al.   JOURNAL OF VIROLOGY

Current knowledge on PB1-F2 of influenza A viruses

(2010) Andi Krumbholz et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence

(2010) C. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza A virus-generated small RNAs regulate the switch from transcription to replication

(2010) J. T. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of the influenza virus RNA polymerase in host shut-off

(2010) Frank T. Vreede et al.   Virulence

Infection studies with two highly pathogenic avian influenza strains (Vietnamese and Indonesian) in Pekin ducks (Anas platyrhynchos), with particular reference to clinical disease, tissue tropism and viral shedding

(2009) John Bingham et al.   AVIAN PATHOLOGY

Emergence of a novel swine-origin influenza A virus (S-OIV) H1N1 virus in humans

(2009) J.S. Malik Peiris et al.   JOURNAL OF CLINICAL VIROLOGY

Role of host-specific amino acids in the pathogenicity of avian H5N1 influenza viruses in mice

(2009) J. H. Kim et al.   JOURNAL OF GENERAL VIROLOGY

High prevalence of amantadine resistance among circulating European porcine influenza A viruses

(2009) A. Krumbholz et al.   JOURNAL OF GENERAL VIROLOGY

Nucleoside Monophosphate Complex Structures of the Endonuclease Domain from the Influenza Virus Polymerase PA Subunit Reveal the Substrate Binding Site inside the Catalytic Center

(2009) C. Zhao et al.   JOURNAL OF VIROLOGY

The Polymerase Acidic Protein Gene of Influenza A Virus Contributes to Pathogenicity in a Mouse Model

(2009) M.-S. Song et al.   JOURNAL OF VIROLOGY

Molecular Determinants of Adaptation of Highly Pathogenic Avian Influenza H7N7 Viruses to Efficient Replication in the Human Host

(2009) E. de Wit et al.   JOURNAL OF VIROLOGY

Detection and Characterization of Influenza A Virus PA-PB2 Interaction through a Bimolecular Fluorescence Complementation Assay

(2009) J. N. Hemerka et al.   JOURNAL OF VIROLOGY

Novel swine-origin influenza A virus in humans: another pandemic knocking at the door

(2009) Martin Michaelis et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

(2009) Puwei Yuan et al.   NATURE

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

(2009) Alexandre Dias et al.   NATURE

Identification of a PA-Binding Peptide with Inhibitory Activity against Influenza A and B Virus Replication

(2009) Kerstin Wunderlich et al.   PLoS One

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

Mechanisms and functional implications of the degradation of host RNA polymerase II in influenza virus infected cells

(2009) Frank T. Vreede et al.   VIROLOGY

Host Restriction of Avian Influenza Viruses at the Level of the Ribonucleoproteins

(2008) Nadia Naffakh et al.   Annual Review of Microbiology

Pathogenesis of highly pathogenic avian influenza A/turkey/Turkey/1/2005 H5N1 in Pekin ducks (Anas platyrhynchos) infected experimentally

(2008) Brandon Z. Löndt et al.   AVIAN PATHOLOGY

Role of Initiating Nucleoside Triphosphate Concentrations in the Regulation of Influenza Virus Replication and Transcription

(2008) F. T. Vreede et al.   JOURNAL OF VIROLOGY

Influenza A Virus Polymerase Is an Integral Component of the CPSF30-NS1A Protein Complex in Infected Cells

(2008) R.-L. Kuo et al.   JOURNAL OF VIROLOGY

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

(2008) Eiji Obayashi et al.   NATURE

The structural basis for cap binding by influenza virus polymerase subunit PB2

(2008) Delphine Guilligay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus

(2008) Gülsah Gabriel et al.   PLoS Pathogens

Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread

(2008) H.-L. Yen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the domain structure of the influenza A virus polymerase acidic protein (PA) and its interaction with the basic protein 1 (PB1) subunit

(2008) Tom S.Y. Guu et al.   VIROLOGY

Genetic Compatibility and Virulence of Reassortants Derived from Contemporary Avian H5N1 and Human H3N2 Influenza A Viruses

(2008) Li-Mei Chen et al.   PLoS Pathogens

Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding

(2007) Helena J. Maier et al.   VIROLOGY