Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway
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Title
Dexmedetomidine Ameliorates Cardiac Ischemia/Reperfusion Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT3 Pathway
Authors
Keywords
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Journal
Drug Design Development and Therapy
Volume Volume 17, Issue -, Pages 3205-3218
Publisher
Informa UK Limited
Online
2023-10-25
DOI
10.2147/dddt.s428024
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Note: Only part of the references are listed.- Dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box O3a (FOXO3a)/p53-upregulated modulator of apoptosis (PUMA) signaling signaling
- (2022) Feng Yun Yang et al. Bioengineered
- Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy
- (2022) Yanhong Xing et al. BASIC RESEARCH IN CARDIOLOGY
- Dexmedetomidine Can Enhance PINK1/Parkin-Mediated Mitophagy in MPTP-Induced PD Mice Model by Activating AMPK
- (2022) Cheng Chen et al. Oxidative Medicine and Cellular Longevity
- Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease
- (2022) Anqi Li et al. Cell Death & Disease
- Dexmedetomidine promotes cell proliferation and inhibits cell apoptosis by regulating LINC00982 and activating the phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT) signaling in hypoxia/reoxygenation-induced H9c2 cells
- (2022) Tao Wang et al. Bioengineered
- Empagliflozin attenuates cardiac microvascular ischemia/reperfusion through activating the AMPKα1/ULK1/FUNDC1/mitophagy pathway
- (2022) Chen Cai et al. Redox Biology
- Modulating Lysine Crotonylation in Cardiomyocytes Improves Myocardial Outcomes
- (2022) Wenqian Cai et al. CIRCULATION RESEARCH
- Shexiang Baoxin Pill attenuates myocardial ischemia/reperfusion injury by activating autophagy via modulating the ceRNA-Map3k8 pathway
- (2022) Yong-Wei Yu et al. PHYTOMEDICINE
- Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart
- (2021) Diana Bou-Teen et al. FREE RADICAL BIOLOGY AND MEDICINE
- SIRT3 consolidates heterochromatin and counteracts senescence
- (2021) Zhiqing Diao et al. NUCLEIC ACIDS RESEARCH
- SIRT3 ameliorates osteoarthritis via regulating chondrocyte autophagy and apoptosis through the PI3K/Akt/mTOR pathway
- (2021) Kai Xu et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Role of Oxidative Stress in Reperfusion following Myocardial Ischemia and Its Treatments
- (2021) Mi Xiang et al. Oxidative Medicine and Cellular Longevity
- Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a/HO-1 signaling pathway
- (2021) Jia Shi et al. Redox Biology
- Dexmedetomidine Attenuates Ischemia/Reperfusion-Induced Myocardial Inflammation and Apoptosis Through Inhibiting Endoplasmic Reticulum Stress Signaling
- (2021) Yu-fan Yang et al. Journal of Inflammation Research
- Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress
- (2021) Inna Rabinovich-Nikitin et al. Autophagy
- NAD + homeostasis in human health and disease
- (2021) Rubén Zapata‐Pérez et al. EMBO Molecular Medicine
- Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation
- (2021) Wei Ou et al. Redox Biology
- NAD + Metabolism in Cardiac Health, Aging, and Disease
- (2021) Mahmoud Abdellatif et al. CIRCULATION
- Dexmedetomidine protects the heart against ischemia reperfusion injury via regulation of the bradykinin receptors
- (2021) Jinchao Song et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation
- (2021) Yifan Lu et al. Redox Biology
- Energy-stress-mediated AMPK activation inhibits ferroptosis
- (2020) Hyemin Lee et al. NATURE CELL BIOLOGY
- Dexmedetomidine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury by Enhancing Autophagy Through Inhibition of the PI3K/AKT/mTOR Pathway
- (2020) Yuan Zhao et al. Frontiers in Pharmacology
- New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury
- (2020) Jin Wang et al. ANGIOGENESIS
- The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses
- (2020) Yongquan Hu et al. Autophagy
- Exendin-4 Protects Against Myocardial Ischemia-Reperfusion Injury by Upregulation of SIRT1 and SIRT3 and Activation of AMPK
- (2020) Refaat A. Eid et al. Journal of Cardiovascular Translational Research
- Mitochondrial ROS in myocardial ischemia reperfusion and remodeling
- (2020) Heiko Bugger et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Dexmedetomidine Enhances Autophagy via α2-AR/AMPK/mTOR Pathway to Inhibit the Activation of NLRP3 Inflammasome and Subsequently Alleviates Lipopolysaccharide-Induced Acute Kidney Injury
- (2020) Tianyuan Yang et al. Frontiers in Pharmacology
- Dexmedetomidine attenuates sepsis-associated inflammation and encephalopathy via central α2A adrenoceptor
- (2020) Bin Mei et al. BRAIN BEHAVIOR AND IMMUNITY
- Dexmedetomidine Ameliorates Hippocampus Injury and Cognitive Dysfunction Induced by Hepatic Ischemia/Reperfusion by Activating SIRT3-Mediated Mitophagy and Inhibiting Activation of the NLRP3 Inflammasome in Young Rats
- (2020) Wenli Yu et al. Oxidative Medicine and Cellular Longevity
- Dexmedetomidine at a dose of 1 µM attenuates H9c2 cardiomyocyte injury under 3 h of hypoxia exposure and 3 h of reoxygenation through the inhibition of endoplasmic reticulum stress
- (2020) Zhipeng Zhu et al. Experimental and Therapeutic Medicine
- Biological Functions of Autophagy Genes: A Disease Perspective
- (2019) Beth Levine et al. CELL
- Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis
- (2019) Yi-Bing Sun et al. Cell Death & Disease
- HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injury
- (2019) Jing Yang et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- TXNIP/Redd1 signalling and excessive autophagy: a novel mechanism of myocardial ischaemia/reperfusion injury in mice
- (2019) Chao Gao et al. CARDIOVASCULAR RESEARCH
- Dexmedetomidine alleviates LPS-induced apoptosis and inflammation in macrophages by eliminating damaged mitochondria via PINK1 mediated mitophagy
- (2019) Yanyan Wang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Paeoniflorin protects against intestinal ischemia/reperfusion by activating LKB1/AMPK and promoting autophagy
- (2019) Jin Wen et al. PHARMACOLOGICAL RESEARCH
- Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease
- (2019) Dominic P. Del Re et al. PHYSIOLOGICAL REVIEWS
- Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease
- (2019) Yan Dong et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress
- (2019) Anna E. Dikalova et al. CIRCULATION RESEARCH
- SIRT3-mediated deacetylation of PRDX3 alleviates mitochondrial oxidative damage and apoptosis induced by intestinal ischemia/reperfusion injury
- (2019) Zhanyu Wang et al. Redox Biology
- The Role of Autophagy in the Heart
- (2018) Sebastiano Sciarretta et al. Annual Review of Physiology
- Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
- (2018) Luis Rajman et al. Cell Metabolism
- AMPK: Sensing Glucose as well as Cellular Energy Status
- (2018) Sheng-Cai Lin et al. Cell Metabolism
- Mechanism and medical implications of mammalian autophagy
- (2018) Ivan Dikic et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases
- (2018) Alice E. Kane et al. CIRCULATION RESEARCH
- Melatonin attenuates myocardial ischemia reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways
- (2018) Ying Zhang et al. JOURNAL OF PINEAL RESEARCH
- Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis
- (2017) Mengen Zhai et al. JOURNAL OF PINEAL RESEARCH
- AMPK: guardian of metabolism and mitochondrial homeostasis
- (2017) Sébastien Herzig et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Aging and Autophagy in the Heart
- (2016) Akihiro Shirakabe et al. CIRCULATION RESEARCH
- TNF and ROS Crosstalk in Inflammation
- (2016) Heiko Blaser et al. TRENDS IN CELL BIOLOGY
- Evolving Therapies for Myocardial Ischemia/Reperfusion Injury
- (2015) Borja Ibáñez et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Histone Deacetylase Inhibition Blunts Ischemia/Reperfusion Injury by Inducing Cardiomyocyte Autophagy
- (2014) Min Xie et al. CIRCULATION
- Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
- (2014) Edward T. Chouchani et al. NATURE
- SIRT1 and other sirtuins in metabolism
- (2014) Hung-Chun Chang et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Reactive Oxygen Species in Inflammation and Tissue Injury
- (2013) Manish Mittal et al. ANTIOXIDANTS & REDOX SIGNALING
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