Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a/HO-1 signaling pathway

Heme oxygenase-1(HO-1) regulates Golgi stress and attenuates endotoxin-induced acute lung injury through hypoxia inducible factor-1α (HIF-1α)/HO-1 signaling pathway

(2021) Xiangyun Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury

(2020) Shiqin Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury

(2020) Zong-Jie Fu et al.   Redox Biology

Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury

(2020) Hajera Amatullah et al.   Redox Biology

Acute respiratory distress syndrome

(2019) Michael A. Matthay et al.   Nature Reviews Disease Primers

Dexmedetomidine Attenuates Lung Injury by Promoting Mitochondrial Fission and Oxygen Consumption

(2019) Jian-Rong Zhang et al.   MEDICAL SCIENCE MONITOR

Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure

(2019) You Wu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

CO-Releasing Molecule-2 Induces Nrf2/ARE-Dependent Heme Oxygenase-1 Expression Suppressing TNF-α-Induced Pulmonary Inflammation

(2019) Chih-Chung Lin et al.   Journal of Clinical Medicine

Oxidative stress in lung cancer patients is associated with altered serum markers of lipid metabolism

(2019) Katarzyna Zabłocka-Słowińska et al.   PLoS One

Nrf2 protects against diverse PM2.5 components-induced mitochondrial oxidative damage in lung cells

(2019) Michal Pardo et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Dexmedetomidine ameliorates LPS induced acute lung injury via GSK-3β/STAT3-NF-κB signaling pathway in rats

(2019) Huayun Zhang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dexmedetomidine alleviates LPS-induced apoptosis and inflammation in macrophages by eliminating damaged mitochondria via PINK1 mediated mitophagy

(2019) Yanyan Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure

(2019) Alpha A. Fowler et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury

(2019) Jia Shi et al.   LABORATORY INVESTIGATION

The role of toll-like receptors in the protective effect of melatonin against doxorubicin-induced pancreatic beta cell toxicity

(2019) Eylem Taskin et al.   LIFE SCIENCES

Dexmedetomidine attenuates lipopolysaccharide induced acute lung injury in rats by inhibition of caveolin-1 downstream signaling

(2019) Jing Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Taurine enhances the protective effect of Dexmedetomidine on sepsis-induced acute lung injury via balancing the immunological system

(2018) Wei Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Dexmedetomidine attenuates lung apoptosis induced by renal ischemia–reperfusion injury through α2AR/PI3K/Akt pathway

(2018) Juanjuan Li et al.   Journal of Translational Medicine

Sepsis and septic shock

(2018) Maurizio Cecconi et al.   LANCET

Mechanisms and treatment of organ failure in sepsis

(2018) Christophe Lelubre et al.   Nature Reviews Nephrology

Metabolic resuscitation strategies to prevent organ dysfunction in sepsis

(2018) Vera Reitsema et al.   ANTIOXIDANTS & REDOX SIGNALING

Roles of Nrf2/HO-1 and HIF-1α/VEGF in lung tissue injury and repair following cerebral ischemia/reperfusion injury

(2018) Jianhua Fan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress

(2018) Jianbin Bi et al.   Redox Biology

Reciprocal regulation of eNOS, H 2 S and CO-synthesizing enzymes in human atheroma: Correlation with plaque stability and effects of simvastatin

(2017) Fragiska Sigala et al.   Redox Biology

Heme Oxygenase-1/Carbon Monoxide-regulated Mitochondrial Dynamic Equilibrium Contributes to the Attenuation of Endotoxin-induced Acute Lung Injury in Rats and in Lipopolysaccharide-activated Macrophages

(2016) Jianbo Yu et al.   ANESTHESIOLOGY

SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages

(2016) Min-Ji Kim et al.   Autophagy

Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics

(2016) Sang-Bin Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of dexmedetomidine on oxygenation and lung mechanics in patients with moderate chronic obstructive pulmonary disease undergoing lung cancer surgery

(2016) Su Hyun Lee et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Carbon monoxide alleviates lipopolysaccharide-induced oxidative stress injury through suppressing the expression of Fis1 in NR8383 cells

(2016) Jia Shi et al.   EXPERIMENTAL CELL RESEARCH

Dexmedetomidine attenuates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress, mitochondrial dysfunction and apoptosis in rats

(2016) Chunlai Fu et al.   Molecular Medicine Reports

PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis

(2015) Hayley Mylroie et al.   CARDIOVASCULAR RESEARCH

Dexmedetomidine Attenuates Bilirubin-Induced Lung Alveolar Epithelial Cell Death In Vitro and In Vivo*

(2015) Jian Cui et al.   CRITICAL CARE MEDICINE

Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans

(2015) Philip Wenzel et al.   EUROPEAN HEART JOURNAL

Isoflurane attenuates LPS-induced acute lung injury by targeting miR-155-HIF1-alpha

(2015) Hong Jiang   Frontiers in Bioscience-Landmark

Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man

(2014) Alexander Jais et al.   CELL

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants

(2013) Bibo Ke et al.   JOURNAL OF HEPATOLOGY

Trolox contributes to Nrf2-mediated protection of human and murine primary alveolar type II cells from injury by cigarette smoke

(2013) E M Messier et al.   Cell Death & Disease

HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium

(2013) Tobias Eckle et al.   PLOS BIOLOGY

Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α

(2011) Molly E. Ogle et al.   NEUROBIOLOGY OF DISEASE

Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis

(2010) Jen A. Tan et al.   INTENSIVE CARE MEDICINE

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols