Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis

Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein–induced Inflammation through a Vagomimetic Action in Mice

(2018) Jun Hu et al.   ANESTHESIOLOGY

Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly

(2018) Dan-Feng Zhang et al.   ANNALS OF SURGERY

Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis by possible reduction of NLRP3 activation and up-regulation of NET expression

(2018) Yong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: The TLR4/NF-κB pathway and the NLRP3 inflammasome may be involved in the mechanism

(2018) Dongpei Yin et al.   BRAIN RESEARCH

Human astrocytes in the diseased brain

(2018) Elena Dossi et al.   BRAIN RESEARCH BULLETIN

Dexmedetomidine promotes liver regeneration in mice after 70% partial hepatectomy by suppressing NLRP3 inflammasome not TLR4/NFκB

(2018) Meihong Lv et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dexmedetomidine-Mediated Prevention of Renal Ischemia-Reperfusion Injury Depends in Part on Cholinergic Anti-Inflammatory Mechanisms

(2018) Jianbo Ma et al.   ANESTHESIA AND ANALGESIA

Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 inflammasome

(2017) Pei Jiang et al.   Journal of Neuroinflammation

Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β

(2017) Paul R. Lee et al.   Journal of Neuroinflammation

Neuroprotection and neurotoxicity in the developing brain: an update on the effects of dexmedetomidine and xenon

(2017) Azeem Alam et al.   NEUROTOXICOLOGY AND TERATOLOGY

Low-dose Dexmedetomidine Improves Sleep Quality Pattern in Elderly Patients after Noncardiac Surgery in the Intensive Care Unit

(2016) Xin-Hai Wu et al.   ANESTHESIOLOGY

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium

(2016) Michael C. Reade et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lipopolysaccharide-Induced Apoptosis of Astrocytes: Therapeutic Intervention by Minocycline

(2015) Arpita Sharma et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Imaging Lymphoid Cell Death In Vivo During Polymicrobial Sepsis*

(2015) Lin Zou et al.   CRITICAL CARE MEDICINE

Dexmedetomidine Attenuates Bilirubin-Induced Lung Alveolar Epithelial Cell Death In Vitro and In Vivo*

(2015) Jian Cui et al.   CRITICAL CARE MEDICINE

Pyroptotic cell death defends against intracellular pathogens

(2015) Ine Jorgensen et al.   IMMUNOLOGICAL REVIEWS

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Dexmedetomidine Attenuates Oxidative Stress Induced Lung Alveolar Epithelial Cell ApoptosisIn Vitro

(2015) Jian Cui et al.   Oxidative Medicine and Cellular Longevity

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Cell Injury and Repair Resulting from Sleep Loss and Sleep Recovery in Laboratory Rats

(2014) Carol A. Everson et al.   SLEEP

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

(2014) Silvia Alfonso-Loeches et al.   Frontiers in Cellular Neuroscience

Revisiting caspases in sepsis

(2014) M Aziz et al.   Cell Death & Disease

Neuroprotective Effects of Dexmedetomidine against Glutamate Agonist-induced Neuronal Cell Death Are Related to Increased Astrocyte Brain-derived Neurotrophic Factor Expression

(2013) Vincent Degos et al.   ANESTHESIOLOGY

On Nontraumatic Brain Injury in Pediatric Critical Illness, Neuropsychologic Short-Term Outcome, Delirium, and Resilience*

(2013) Jan N. M. Schieveld et al.   CRITICAL CARE MEDICINE

Pyroptotic death storms and cytopenia

(2013) Ben A Croker et al.   CURRENT OPINION IN IMMUNOLOGY

Shikonin Kills Glioma Cells through Necroptosis Mediated by RIP-1

(2013) Chuanjiang Huang et al.   PLoS One

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Extracellular Chromatin Is an Important Mediator of Ischemic Stroke in Mice

(2012) Simon F. De Meyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit

(2012) Juliana Barr et al.   CRITICAL CARE MEDICINE

Current trends in inflammatory and immunomodulatory mediators in sepsis

(2012) M. Aziz et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Novel Therapeutic Targets for Sepsis: Regulation of Exaggerated Inflammatory Responses

(2012) Akihisa Matsuda et al.   JOURNAL OF NIPPON MEDICAL SCHOOL

Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system

(2011) W. Liu et al.   LIFE SCIENCES

Sleep and immune function

(2011) Luciana Besedovsky et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

Characterization of the Postconditioning Effect of Dexmedetomidine in Mouse Organotypic Hippocampal Slice Cultures Exposed to Oxygen and Glucose Deprivation

(2010) Souhayl Dahmani et al.   ANESTHESIOLOGY

Dexmedetomidine provides cortical neuroprotection: impact on anaesthetic-induced neuroapoptosis in the rat developing brain

(2009) R. D. SANDERS et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Dexmedetomidine Attenuates Isoflurane-induced Neurocognitive Impairment in Neonatal Rats

(2009) Robert D. Sanders et al.   ANESTHESIOLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Sustained hippocampal IL-1β overexpression impairs contextual and spatial memory in transgenic mice

(2009) Amy M. Hein et al.   BRAIN BEHAVIOR AND IMMUNITY

Dexmedetomidine vs Midazolam for Sedation of Critically Ill PatientsA Randomized Trial

(2009) Richard R. Riker   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

NOS2 Gene Deficiency Protects from Sepsis-Induced Long-Term Cognitive Deficits

(2009) M. Weberpals et al.   JOURNAL OF NEUROSCIENCE

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Sepsis: the dark side of histones

(2009) Catherine Chaput et al.   NATURE MEDICINE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation