Dexmedetomidine Ameliorates Hippocampus Injury and Cognitive Dysfunction Induced by Hepatic Ischemia/Reperfusion by Activating SIRT3-Mediated Mitophagy and Inhibiting Activation of the NLRP3 Inflammasome in Young Rats

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

(2020) Ming He et al.   Cell Metabolism

Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits

(2020) Rebecca J. Henry et al.   JOURNAL OF NEUROSCIENCE

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

(2020) Jae-Hyeon Park et al.   Molecular Neurodegeneration

A Newly Synthesized Rhamnoside Derivative Alleviates Alzheimer’s Amyloid-β-Induced Oxidative Stress, Mitochondrial Dysfunction, and Cell Senescence through Upregulating SIRT3

(2020) Yi Li et al.   Oxidative Medicine and Cellular Longevity

Therapeutic Strategies for Regulating Mitochondrial Oxidative Stress

(2020) Yuma Yamada et al.   Biomolecules

Electrical stimulation inhibits Val-boroPro-induced pyroptosis in THP-1 macrophages via sirtuin3 activation to promote autophagy and inhibit ROS generation

(2020) Lin Cong et al.   Aging-US

Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury: Involvement of TLR4/NF-κB and Nrf2/Keap-1 Signaling

(2020) Jianmei Gao et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of sirtuin1 protects against ischemia/reperfusion-induced acute kidney injury

(2020) Li Gong et al.   BIOMEDICINE & PHARMACOTHERAPY

Dexmedetomidine postconditioning suppresses myocardial ischemia/reperfusion injury by activating the SIRT1/mTOR axis

(2020) Xiong Zhang et al.   BIOSCIENCE REPORTS

lncRNA Oip5‐as1 attenuates myocardial ischaemia/reperfusion injury by sponging miR‐29a to activate the SIRT1/AMPK/PGC1α pathway

(2020) Xiaowei Niu et al.   CELL PROLIFERATION

Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury

(2020) Zhongyuan Liu et al.   Journal of Neuroinflammation

Dexmedetomidine improves propofol-induced neuronal injury in rat hippocampus with the involvement of miR-34a and the PI3K/Akt signaling pathway

(2020) Na Xing et al.   LIFE SCIENCES

5‐Heptadecylresorcinol, a Biomarker for Whole Grain Rye Consumption, Ameliorates Cognitive Impairments and Neuroinflammation in APP/PS1 Transgenic Mice

(2020) Jie Liu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

δ-Opioid Receptors, microRNAs, and Neuroinflammation in Cerebral Ischemia/Hypoxia

(2020) Yi-Meng Chen et al.   Frontiers in Immunology

Gut–Liver Axis and Inflammasome Activation in Cholangiocyte Pathophysiology

(2020) Luca Maroni et al.   Cells

RTN4B‐mediated suppression of Sirtuin 2 activity ameliorates β‐amyloid pathology and cognitive impairment in Alzheimer's disease mouse model

(2020) Yan Wang et al.   AGING CELL

Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway

(2020) Zhi-Gang Mei et al.   Aging-US

Caffeine Targets SIRT3 to Enhance SOD2 Activity in Mitochondria

(2020) Huanhuan Xu et al.   Frontiers in Cell and Developmental Biology

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

(2019) Hanzhi Luo et al.   Cell Reports

Ischemia Reperfusion Injury in Liver Transplantation: Cellular and Molecular mechanisms

(2019) Wasim A. Dar et al.   LIVER INTERNATIONAL

Dephosphorylation by calcineurin regulates translocation of dynamin-related protein 1 to mitochondria in hepatic ischemia reperfusion induced hippocampus injury in young mice

(2019) Xiangyang Yu et al.   BRAIN RESEARCH

Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis

(2019) Theodomir Dusabimana et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1–PGC-1α axis

(2019) Sashaina E. Fanibunda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

(2019) Yong Liu et al.   Nature Communications

The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

(2019) Nathan Kelley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus

(2019) Yao-Chung Chuang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirt3 modulate renal ischemia‐reperfusion injury through enhancing mitochondrial fusion and activating the ERK‐OPA1 signaling pathway

(2019) Qiang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitophagy and Neuroprotection

(2019) Guofeng Lou et al.   TRENDS IN MOLECULAR MEDICINE

Dexmedetomidine alleviates LPS-induced apoptosis and inflammation in macrophages by eliminating damaged mitochondria via PINK1 mediated mitophagy

(2019) Yanyan Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Health‐Related Quality of Life and Cognitive Functioning in Pediatric Liver Transplant Recipients

(2019) Daniella Ohnemus et al.   LIVER TRANSPLANTATION

Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats

(2019) He et al.   Cells

Dexmedetomidine attenuates neuronal injury after spinal cord ischaemia‐reperfusion injury by targeting the CNPY2‐endoplasmic reticulum stress signalling

(2019) Lina Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

AGK2 Alleviates Lipopolysaccharide Induced Neuroinflammation through Regulation of Mitogen-Activated Protein Kinase Phosphatase-1

(2019) Fangzhou Jiao et al.   Journal of Neuroimmune Pharmacology

Exosomes Mediate Hippocampal and Cortical Neuronal Injury Induced by Hepatic Ischemia-Reperfusion Injury through Activating Pyroptosis in Rats

(2019) Limei Zhang et al.   Oxidative Medicine and Cellular Longevity

N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice

(2019) Min Hee Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-Acetylcysteine Attenuates the Increasing Severity of Distant Organ Liver Dysfunction after Acute Kidney Injury in Rats Exposed to Bisphenol A

(2019) Wachirasek Peerapanyasut et al.   Antioxidants

Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

(2019) Anna E. Dikalova et al.   CIRCULATION RESEARCH

Cardiomyocyte-Specific JunD Overexpression Increases Infarct Size following Ischemia/Reperfusion Cardiac Injury by Downregulating Sirt3

(2019) Alexander Akhmedov et al.   THROMBOSIS AND HAEMOSTASIS

SIRT3-mediated deacetylation of PRDX3 alleviates mitochondrial oxidative damage and apoptosis induced by intestinal ischemia/reperfusion injury

(2019) Zhanyu Wang et al.   Redox Biology

SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress

(2018) Patricia Rada et al.   ANTIOXIDANTS & REDOX SIGNALING

Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: The TLR4/NF-κB pathway and the NLRP3 inflammasome may be involved in the mechanism

(2018) Dongpei Yin et al.   BRAIN RESEARCH

Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor

(2018) Jie Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravenous dexmedetomidine pre-medication reduces the required minimum alveolar concentration of sevoflurane for smooth tracheal extubation in anesthetized children: a randomized clinical trial

(2018) Meiqin Di et al.   BMC Anesthesiology

Evaluation of the Neuroprotective Effect of Sirt3 in Experimental Stroke

(2018) Rajkumar Verma et al.   Translational Stroke Research

Dexmedetomidine attenuation of renal ischaemia-reperfusion injury requires sirtuin 3 activation

(2018) Y. Si et al.   BRITISH JOURNAL OF ANAESTHESIA

New Evidence of Mitochondria Dysfunction in the Female Alzheimer's Disease Brain: Deficiency of Estrogen Receptor-β

(2018) Jiangang Long et al.   JOURNAL OF ALZHEIMERS DISEASE

Src is Implicated in Hepatic Ischemia Reperfusion-Induced Hippocampus Injury and Long-Term Cognitive Impairment in Young Mice via NMDA Receptor Subunit 2A Activation

(2018) Xiangyang Yu et al.   NEUROSCIENCE

WISP1 mediates lung injury following hepatic ischemia reperfusion dependent on TLR4 in mice

(2018) Yao Tong et al.   BMC Pulmonary Medicine

Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury

(2017) Claire Thornton et al.   FEBS LETTERS

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

Hepatic ischemia/reperfusion injury associates with acute kidney injury in liver transplantation: Prospective cohort study

(2017) Ina Jochmans et al.   LIVER TRANSPLANTATION

Pediatric Liver Transplantation

(2017) Nidhi Rawal et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Early and late neurological complications of liver transplantation in pediatric patients

(2017) Serdal Gungor et al.   PEDIATRIC TRANSPLANTATION

Mitochondria and the NLRP3 inflammasome: physiological and pathological relevance

(2016) Je-Wook Yu et al.   ARCHIVES OF PHARMACAL RESEARCH

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

(2016) Aiwu Cheng et al.   Cell Metabolism

The intersection of cell death and inflammasome activation

(2016) James E. Vince et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neuropsychological functioning and health-related quality of life in pediatric liver disease

(2016) Lisa G. Sorensen   CURRENT OPINION IN PEDIATRICS

Sirtuin 2 aggravates postischemic liver injury by deacetylating mitogen-activated protein kinase phosphatase-1

(2016) Jie Wang et al.   HEPATOLOGY

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

The Protective Roles of ROS-Mediated Mitophagy on125I Seeds Radiation Induced Cell Death in HCT116 Cells

(2016) Lelin Hu et al.   Oxidative Medicine and Cellular Longevity

Structural mechanisms of cyclophilin D-dependent control of the mitochondrial permeability transition pore

(2015) Manuel Gutiérrez-Aguilar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D

(2015) T. Bochaton et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Practicality of Intermittent Fasting in Humans and its Effect on Oxidative Stress and Genes Related to Aging and Metabolism

(2015) Martin P. Wegman et al.   REJUVENATION RESEARCH

Global Consequences of Liver Ischemia/Reperfusion Injury

(2014) Constantinos Nastos et al.   Oxidative Medicine and Cellular Longevity

Differential expression of sirtuin family members in the developing, adult, and aged rat brain

(2014) Elena Sidorova-Darmos et al.   Frontiers in Aging Neuroscience

Peroxiredoxin 3 levels regulate a mitochondrial redox setpoint in malignant mesothelioma cells

(2014) Brian Cunniff et al.   Redox Biology

Sirtuins in stress response: guardians of the genome

(2013) L Bosch-Presegué et al.   ONCOGENE

Role of sirtuins in ischemia-reperfusion injury

(2013) Eirini Pantazi   WORLD JOURNAL OF GASTROENTEROLOGY

Preoperative evaluation, premedication, and induction of anesthesia in infants and children

(2012) Suzanne Strom   Current Opinion in Anesthesiology

Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism

(2012) Ruben Nogueiras et al.   PHYSIOLOGICAL REVIEWS

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects

(2011) Bryan J. Bartlett et al.   Autophagy

Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission

(2011) O. Pascual et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming

(2010) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3

(2010) Lei Jin et al.   PROTEIN SCIENCE

Dexmedetomidine Attenuates Isoflurane-induced Neurocognitive Impairment in Neonatal Rats

(2009) Robert D. Sanders et al.   ANESTHESIOLOGY