Dexmedetomidine Can Enhance PINK1/Parkin-Mediated Mitophagy in MPTP-Induced PD Mice Model by Activating AMPK

Mfn2 Overexpression Attenuates MPTP Neurotoxicity In Vivo

(2021) Fanpeng Zhao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dexmedetomidine protects SH‐SY5Y cells against MPP + ‐induced declining of mitochondrial membrane potential and cell cycle deficits

(2021) Yaohua Chen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Dexmedetomidine Alleviates Lipopolysaccharide-Induced Hippocampal Neuronal Apoptosis via Inhibiting the p38 MAPK/c-Myc/CLIC4 Signaling Pathway in Rats

(2021) Yongping Chen et al.   MOLECULAR NEUROBIOLOGY

Vitexin Mitigates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Mitochondrial Dysfunction via Epac1-Rap1 Signaling

(2021) Huanhua Yang et al.   Oxidative Medicine and Cellular Longevity

Glucagon-Like Peptide-1 Receptor Agonist Ameliorates 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Neurotoxicity Through Enhancing Mitophagy Flux and Reducing α-Synuclein and Oxidative Stress

(2021) Tsu-Kung Lin et al.   Frontiers in Molecular Neuroscience

Melatonin Attenuates Neuroinflammation by Down-Regulating NLRP3 Inflammasome via a SIRT1-Dependent Pathway in MPTP-Induced Models of Parkinson’s Disease

(2021) Ran Zheng et al.   Journal of Inflammation Research

Redox homeostasis, oxidative stress and mitophagy

(2020) Carla Garza-Lombó et al.   MITOCHONDRION

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

(2020) Preston Ge et al.   Molecular Neurodegeneration

Neuroprotective Effect of Chlorogenic Acid on Mitochondrial Dysfunction-Mediated Apoptotic Death of DA Neurons in a Parkinsonian Mouse Model

(2020) Saumitra Sen Singh et al.   Oxidative Medicine and Cellular Longevity

Deep brain stimulation programming in Parkinson's disease: Introduction of current issues and perspectives

(2020) M. Aubignat et al.   REVUE NEUROLOGIQUE

Influence of Anesthesia and Clinical Variables on the Firing Rate, Coefficient of Variation and Multi-Unit Activity of the Subthalamic Nucleus in Patients with Parkinson’s Disease

(2020) Michael J. Bos et al.   Journal of Clinical Medicine

Mitophagy, Mitochondrial Homeostasis, and Cell Fate

(2020) Kaili Ma et al.   Frontiers in Cell and Developmental Biology

Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease

(2020) Sahabuddin Ahmed et al.   BRAIN BEHAVIOR AND IMMUNITY

Targeting mitophagy in Parkinson's disease

(2020) Emily H. Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dose dependent reduction in median effective concentration (EC50) of ropivacaine with adjuvant dexmedetomidine in labor epidural analgesia: An up-down sequential allocation study

(2020) Lin Liu et al.   JOURNAL OF CLINICAL ANESTHESIA

Glycine nano-selenium prevents brain oxidative stress and neurobehavioral abnormalities caused by MPTP in rats

(2020) Dong Yue et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Dexmedetomidine ameliorates lipopolysaccharide‐induced acute kidney injury in rats by inhibiting inflammation and oxidative stress via the GSK‐3β/Nrf2 signaling pathway

(2019) Xiujing Feng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mitophagy in Parkinson’s Disease: From Pathogenesis to Treatment

(2019) Jia Liu et al.   Cells

Dexmedetomidine alleviates LPS-induced apoptosis and inflammation in macrophages by eliminating damaged mitochondria via PINK1 mediated mitophagy

(2019) Yanyan Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Salidroside Protects Dopaminergic Neurons by Enhancing PINK1/Parkin-Mediated Mitophagy

(2019) Ruru Li et al.   Oxidative Medicine and Cellular Longevity

Dexmedetomidine attenuates the induction and reverses the progress of 6-hydroxydopamine- induced parkinsonism; involvement of KATP channels, alpha 2 adrenoceptors and anti-inflammatory mechanisms

(2019) Azita Minaei et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Emerging concepts of mitochondrial dysfunction in Parkinson’s disease progression: Pathogenic and therapeutic implications

(2019) Linchi Rani et al.   MITOCHONDRION

Repairing Mitochondrial Dysfunction in Disease

(2018) Vincenzo Sorrentino et al.   Annual Review of Pharmacology and Toxicology

Role of mitochondrial ROS in the brain: from physiology to neurodegeneration

(2018) Plamena R. Angelova et al.   FEBS LETTERS

The mitochondrial ribosomal protein L13 is critical for the structural and functional integrity of the mitochondrion inPlasmodium falciparum

(2018) Hangjun Ke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria: A master regulator in macrophage and T cell immunity

(2018) Pu-Ste Liu et al.   MITOCHONDRION

Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson’s Disease Patients

(2018) Sokhna M. S. Yakhine-Diop et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial quality control: The role of mitophagy in aging

(2018) Ruoyang Shi et al.   TRENDS IN CARDIOVASCULAR MEDICINE

The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II

(2018) Anna Onnis et al.   Autophagy

Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy

(2018) Winifred W. Yau et al.   Autophagy

The role of mitochondria in aging

(2018) Ji Yong Jang et al.   JOURNAL OF CLINICAL INVESTIGATION

Dexmedetomidine pretreatment inhibits cerebral ischemia/reperfusion‑induced neuroinflammation via activation of AMPK

(2018) Zhenhong Wang et al.   Molecular Medicine Reports

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Effects of Dexmedetomidine on Microelectrode Recordings of the Subthalamic Nucleus during Deep Brain Stimulation Surgery: A Retrospective Analysis

(2017) Letha Mathews et al.   STEREOTACTIC AND FUNCTIONAL NEUROSURGERY

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

(2017) Rhianna C. Laker et al.   Nature Communications

Patients' Perioperative Experience of Awake Deep-Brain Stimulation for Parkinson Disease

(2017) Eoin Mulroy et al.   World Neurosurgery

The MPTP Story

(2017) J. William Langston   Journal of Parkinsons Disease

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation

(2017) Bei Wang et al.   CIRCULATION RESEARCH

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

(2016) Fiona A. Ross et al.   FEBS Journal

Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance

(2016) Ming Lu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Quantification of mitochondrial morphology in neurites of dopaminergic neurons using multiple parameters

(2016) Lyle Wiemerslage et al.   JOURNAL OF NEUROSCIENCE METHODS

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Haidong Wang et al.   LANCET

Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson’s disease model induced by MPTP

(2016) Emily Filichia et al.   Scientific Reports

Molecular mechanisms mediating mitochondrial dynamics and mitophagy and their functional roles in the cardiovascular system

(2015) Yoshiyuki Ikeda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro

(2015) Robert A. Whittington et al.   NEUROBIOLOGY OF AGING

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

(2013) Krishnendu Sinha et al.   ARCHIVES OF TOXICOLOGY

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

(2013) Seok Min Jin et al.   Autophagy

Mitochondrial Diseases of the Brain

(2013) Rajnish K. Chaturvedi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Advances in the genetics of Parkinson disease

(2013) Joanne Trinh et al.   Nature Reviews Neurology

Mitochondrial dysfunction and oxidative stress in Parkinson's disease

(2013) Sudhakar Raja Subramaniam et al.   PROGRESS IN NEUROBIOLOGY

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

(2012) Michael Lazarou et al.   DEVELOPMENTAL CELL

Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease

(2012) Michael H. Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation

(2012) Alfonso Fasano et al.   LANCET NEUROLOGY

Late-stage Parkinson disease

(2012) Miguel Coelho et al.   Nature Reviews Neurology

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMP-activated protein kinase is activated in Parkinson’s disease models mediated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

(2009) Jae-Sun Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

(2008) Hirokazu Fukui et al.   TRENDS IN NEUROSCIENCES