Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress

Tobacco Smoking Induces Cardiovascular Mitochondrial Oxidative Stress, Promotes Endothelial Dysfunction and Enhances Hypertension

(2019) Sergey Dikalov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Crosstalk between mitochondrial hyperacetylation and oxidative stress in vascular dysfunction and hypertension

(2019) Sergey I Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of endothelial NAD+ deficiency in age-related vascular dysfunction

(2019) Anna Csicsar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sirt3 Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by Opa1 Gene Transfer

(2019) Ariela Benigni et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of Mitochondrial Oxidative Damage Improves Reendothelialization Capacity of Endothelial Progenitor Cells via SIRT3 (Sirtuin 3)-Enhanced SOD2 (Superoxide Dismutase 2) Deacetylation in Hypertension

(2019) Jiang He et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Telomerase reverse transcriptase protects against angiotensin II-induced microvascular endothelial dysfunction

(2018) Karima Ait-Aissa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming

(2018) Eric I. Elliott et al.   JOURNAL OF IMMUNOLOGY

A Metabolic Basis for Endothelial-to-Mesenchymal Transition

(2018) Jianhua Xiong et al.   MOLECULAR CELL

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases

(2018) Alice E. Kane et al.   CIRCULATION RESEARCH

Enhancing Mitochondrial Health to Treat Hypertension

(2018) Alfonso Eirin et al.   CURRENT HYPERTENSION REPORTS

Oxidative Stress, Inflammation, and Vascular Aging in Hypertension

(2017) Tomasz J. Guzik et al.   HYPERTENSION

Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2

(2017) Javier Traba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015

(2017) Gregory A. Roth et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

(2017) Vinodkumar B. Pillai et al.   Oncotarget

Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice

(2016) Vinodkumar B. Pillai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive StimuliNovelty and Significance

(2016) Hana A. Itani et al.   CIRCULATION RESEARCH

Contribution of mitochondrial oxidative stress to hypertension

(2016) Sergey I. Dikalov et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Activation of Human T Cells in HypertensionNovelty and Significance

(2016) Hana A. Itani et al.   HYPERTENSION

Mitochondrial Cyclophilin D in Vascular Oxidative Stress and HypertensionNovelty and Significance

(2016) Hana A. Itani et al.   HYPERTENSION

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

(2016) Kaname Akamata et al.   Oncotarget

The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells

(2016) Jingyan Han et al.   Redox Biology

Sirt3–MnSOD axis represses nicotine-induced mitochondrial oxidative stress and mtDNA damage in osteoblasts

(2015) Yong Li et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes

(2015) Liang Zhang et al.   CELL CYCLE

Inflammation, Immunity, and Hypertensive End-Organ Damage

(2015) W. G. McMaster et al.   CIRCULATION RESEARCH

SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat–Fed Mice

(2015) Louise Lantier et al.   DIABETES

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

(2015) Stephan Winnik et al.   EUROPEAN HEART JOURNAL

Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum

(2015) Margarida Freitas et al.   Journal of Sexual Medicine

SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β

(2015) Nagalingam R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells

(2015) Irina Gurt et al.   PLoS One

Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3

(2015) Vinodkumar B. Pillai et al.   Nature Communications

Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss

(2014) Kevin D. Brown et al.   Cell Metabolism

Mitochondrial injury and dysfunction in hypertension-induced cardiac damage

(2014) A. Eirin et al.   EUROPEAN HEART JOURNAL

Role of arterial telomere dysfunction in hypertension

(2014) R. Garrett Morgan et al.   JOURNAL OF HYPERTENSION

Sirtuins: guardians of mammalian healthspan

(2014) William Giblin et al.   TRENDS IN GENETICS

Nox2 as a potential target of mitochondrial superoxide and its role in endothelial oxidative stress

(2013) Rafal R. Nazarewicz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nox2-Induced Production of Mitochondrial Superoxide in Angiotensin II-Mediated Endothelial Oxidative Stress and Hypertension

(2013) Sergey I. Dikalov et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of MnSOD Enzymatic Activity by Sirt3 Connects the Mitochondrial Acetylome Signaling Networks to Aging and Carcinogenesis

(2013) Randa Tao et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

The Mosaic Theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension

(2013) David G. Harrison   Journal of the American Society of Hypertension

E. coliEndotoxin Modulates the Expression of Sirtuin Proteins in PBMC in Humans

(2013) Angela Storka et al.   MEDIATORS OF INFLAMMATION

SIRT3 Reverses Aging-Associated Degeneration

(2013) Katharine Brown et al.   Cell Reports

Hypertension in the elderly: Some practical considerations

(2012) K. N. CHAUDHRY et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Role of Renin-Angiotensin System in Inflammation, Immunity and Aging

(2012) Luciano S.A. Capettini et al.   CURRENT PHARMACEUTICAL DESIGN

Vascular Inflammatory Cells in Hypertension

(2012) David G. Harrison et al.   Frontiers in Physiology

Combination therapy as initial treatment for newly diagnosed hypertension

(2011) James B. Byrd et al.   AMERICAN HEART JOURNAL

Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation

(2011) Seonmin Lee et al.   CELL RESEARCH

Quantifying nuclear p65 as a parameter for NF-κB activation: Correlation between ImageStream cytometry, microscopy, and Western blot

(2011) Orla Maguire et al.   CYTOMETRY PART A

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Cross talk between mitochondria and NADPH oxidases

(2011) Sergey Dikalov   FREE RADICAL BIOLOGY AND MEDICINE

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

(2010) Anna E. Dikalova et al.   CIRCULATION RESEARCH

VE-cadherin: at the front, center, and sides of endothelial cell organization and function

(2010) Elizabeth S Harris et al.   CURRENT OPINION IN CELL BIOLOGY

Sirt3-Mediated Deacetylation of Evolutionarily Conserved Lysine 122 Regulates MnSOD Activity in Response to Stress

(2010) Randa Tao et al.   MOLECULAR CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Endurance Exercise as a Countermeasure for Aging

(2008) I. R. Lanza et al.   DIABETES

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA