Dexmedetomidine Enhances Autophagy via α2-AR/AMPK/mTOR Pathway to Inhibit the Activation of NLRP3 Inflammasome and Subsequently Alleviates Lipopolysaccharide-Induced Acute Kidney Injury

Activation of AMP‐activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness

(2020) Kui Jin et al.   FASEB JOURNAL

STC-1 ameliorates renal injury in diabetic nephropathy by inhibiting the expression of BNIP3 through the AMPK/SIRT3 pathway

(2019) Zhiwen Liu et al.   LABORATORY INVESTIGATION

Dexmedetomidine ameliorates lipopolysaccharide‐induced acute kidney injury in rats by inhibiting inflammation and oxidative stress via the GSK‐3β/Nrf2 signaling pathway

(2019) Xiujing Feng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CRRL269

(2019) Yang Chen et al.   CIRCULATION RESEARCH

Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1β Expression in Primary Mouse Cardiac Fibroblasts

(2019) May-Kristin Torp et al.   Frontiers in Immunology

The neuroprotection of progesterone against Aβ-induced NLRP3-Caspase-1 inflammasome activation via enhancing autophagy in astrocytes

(2019) Yang Hong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dexmedetomidine alleviates LPS-induced apoptosis and inflammation in macrophages by eliminating damaged mitochondria via PINK1 mediated mitophagy

(2019) Yanyan Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR

(2019) Meng Deng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Zika Virus Infection Induces Acute Kidney Injury Through Activating NLRP3 Inflammasome Via Suppressing Bcl-2

(2019) Ting Liu et al.   Frontiers in Immunology

CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

(2019) Meng-Chen Lu et al.   Redox Biology

rhEPO inhibited cell apoptosis to alleviate acute kidney injury in sepsis by AMPK/SIRT1 activated autophagy

(2019) Kan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ursolic acid exhibits anti-inflammatory effects through blocking TLR4-MyD88 pathway mediated by autophagy

(2019) Jun Zhao et al.   CYTOKINE

Mitochondrial oxidative phosphorylation complex regulates NLRP3 inflammasome activation and predicts patient survival in nasopharyngeal carcinoma

(2019) I-Che Chung et al.   MOLECULAR & CELLULAR PROTEOMICS

Lithium targeting of AMPK protects against cisplatin-induced acute kidney injury by enhancing autophagy in renal proximal tubular epithelial cells

(2019) Hui Bao et al.   FASEB JOURNAL

Anticancer and genotoxicity effect of (Clausena lansium (Lour.) Skeels) Peel ZnONPs on neuroblastoma (SH-SY5Y) cells through the modulation of autophagy mechanism

(2019) Fu Li et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: The TLR4/NF-κB pathway and the NLRP3 inflammasome may be involved in the mechanism

(2018) Dongpei Yin et al.   BRAIN RESEARCH

Long non-coding RNA NEAT1 plays an important role in sepsis-induced acute kidney injury by targeting miR-204 and modulating the NF-κB pathway

(2018) Yi Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

mROS-TXNIP axis activates NLRP3 inflammasome to mediate renal injury during ischemic AKI

(2018) Yi Wen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dexmedetomidine attenuates lung apoptosis induced by renal ischemia–reperfusion injury through α2AR/PI3K/Akt pathway

(2018) Juanjuan Li et al.   Journal of Translational Medicine

Dexmedetomidine restores septic renal function via promoting inflammation resolution in a rat sepsis model

(2018) Rongzong Qiu et al.   LIFE SCIENCES

Autophagy in ischemic stroke

(2018) Pei Wang et al.   PROGRESS IN NEUROBIOLOGY

Dexmedetomidine restores autophagy and cardiac dysfunction in rats with streptozotocin-induced diabetes mellitus

(2018) Ju Eun Oh et al.   ACTA DIABETOLOGICA

Dexmedetomidine pretreatment inhibits cerebral ischemia/reperfusion‑induced neuroinflammation via activation of AMPK

(2018) Zhenhong Wang et al.   Molecular Medicine Reports

Renoprotective effects of dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats

(2018) Seung Hyun Kim et al.   PLoS One

The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasome activation in aldosterone-induced renal injury model mice

(2018) Yuji Sogawa et al.   PLoS One

Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5

(2018) Lena Heinbockel et al.   Frontiers in Immunology

Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome

(2018) Wei-Ting Wong et al.   Frontiers in Immunology

Pharmacological inhibition of autophagy by 3-MA attenuates hyperuricemic nephropathy

(2018) Jinfang Bao et al.   CLINICAL SCIENCE

Inflammasome-Independent Role of NLRP3 Mediates Mitochondrial Regulation in Renal Injury

(2018) Su-Mi Kim et al.   Frontiers in Immunology

Bexarotene, a Selective RXRα Agonist, Reverses Hypotension Associated with Inflammation and Tissue Injury in a Rat Model of Septic Shock

(2017) Bahar Tunctan et al.   INFLAMMATION

Dexmedetomidine protects against cisplatin-induced acute kidney injury in mice through regulating apoptosis and inflammation

(2017) H. Liang et al.   INFLAMMATION RESEARCH

Metformin attenuates albumin-induced alterations in renal tubular cells in vitro

(2017) Soumaya Allouch et al.   JOURNAL OF CELLULAR PHYSIOLOGY

NQO1 Deficiency Leads Enhanced Autophagy in Cisplatin-Induced Acute Kidney Injury Through the AMPK/TSC2/mTOR Signaling Pathway

(2016) Tae-Won Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Dexmedetomidine acts as an oxidative damage prophylactic in rats exposed to ionizing radiation

(2016) Dilek Kutanis et al.   JOURNAL OF CLINICAL ANESTHESIA

Autophagy in kidney disease and aging: lessons from rodent models

(2016) Olivia Lenoir et al.   KIDNEY INTERNATIONAL

Hyperin protects against LPS-induced acute kidney injury by inhibiting TLR4 and NLRP3 signaling pathways

(2016) Gong Chunzhi et al.   Oncotarget

NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis

(2016) Jianxiao Shen et al.   Scientific Reports

Review paper Current views on the mechanisms of immune responses to trauma and infection

(2015) Aneta Małgorzata Binkowska et al.   Central European Journal of Immunology

Autophagy, Metabolism, and Cancer

(2015) E. White et al.   CLINICAL CANCER RESEARCH

The Role of Autophagy in Kidney Inflammatory Injury via the NF-κB Route Induced by LPS

(2015) Yu Wu et al.   International Journal of Medical Sciences

Interleukin-1 function and role in rheumatic disease

(2015) Georg Schett et al.   Nature Reviews Rheumatology

Sepsis-induced acute kidney injury revisited

(2014) Alexander Zarbock et al.   Current Opinion in Critical Care

Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activation

(2013) Yanna Si et al.   Journal of Translational Medicine

Acute Lung Injury and Acute Kidney Injury Are Established by Four Hours in Experimental Sepsis and Are Improved with Pre, but Not Post, Sepsis Administration of TNF-α Antibodies

(2013) Rhea Bhargava et al.   PLoS One

A Unified Theory of Sepsis-Induced Acute Kidney Injury

(2013) Hernando Gomez et al.   SHOCK

Endothelial Peroxisomal Dysfunction and Impaired Pexophagy Promotes Oxidative Damage in Lipopolysaccharide-Induced Acute Kidney Injury

(2012) Radovan Vasko et al.   ANTIOXIDANTS & REDOX SIGNALING

The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy

(2012) Yu Lei et al.   IMMUNITY

Serum IL-18 Is Closely Associated with Renal Tubulointerstitial Injury and Predicts Renal Prognosis in IgA Nephropathy

(2012) Beili Shi et al.   MEDIATORS OF INFLAMMATION

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

NLRP3 Inflammasome Activation Induced by Engineered Nanomaterials

(2012) Bingbing Sun et al.   Small

Sepsis and Acute Kidney Injury

(2011) A. Zarjou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy is a therapeutic target in anticancer drug resistance

(2010) Suning Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Animal models of sepsis and sepsis-induced kidney injury

(2009) Kent Doi et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival

(2009) Raghavan Murugan et al.   KIDNEY INTERNATIONAL

Renal replacement therapy for acute renal failure: a survey of practice in adult intensive care units in the United Kingdom

(2008) J. J. Gatward et al.   ANAESTHESIA

Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy

(2008) Sean M. Bagshaw et al.   INTENSIVE CARE MEDICINE

Kidney injury molecule–1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells

(2008) Takaharu Ichimura et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of Dexmedetomidine on Regulating Endotoxin-Induced Up-Regulation of Inflammatory Molecules in Murine Macrophages

(2008) Yen-Chun Lai et al.   JOURNAL OF SURGICAL RESEARCH