Dexmedetomidine attenuates ischemia and reperfusion-induced cardiomyocyte injury through p53 and forkhead box O3a (FOXO3a)/p53-upregulated modulator of apoptosis (PUMA) signaling signaling

miR-22 protect PC12 from ischemia/reperfusion-induced injury by targeting p53 upregulated modulator of apoptosis (PUMA)

(2020) Hongmei Jiao et al.   Bioengineered

Dexmedetomidine protects against lidocaine-induced neurotoxicity through SIRT1 downregulation-mediated activation of FOXO3a

(2020) L-N Zheng et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Circulating extracellular vesicles from patients with valvular heart disease induce neutrophil chemotaxis via FOXO3a and the inhibiting role of dexmedetomidine

(2020) Hao-Xiang Yuan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dexmedetomidine inhibits pyroptosis by down-regulating miR-29b in myocardial ischemia reperfusion injury in rats

(2020) Yi Zhong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dexmedetomidine protects hippocampal neurons against hypoxia/reoxygenation-induced apoptosis through activation HIF-1α/p53 signaling

(2019) Yan Gao et al.   LIFE SCIENCES

Protective effect of dexmedetomidine against myocardial ischemia-reperfusion injury in rabbits

(2018) Jianjun Ren et al.   Acta Cirurgica Brasileira

Mitochondria are transported along microtubules in membrane nanotubes to rescue distressed cardiomyocytes from apoptosis

(2018) Jing Shen et al.   Cell Death & Disease

Critical role of FOXO3a in carcinogenesis

(2018) Ying Liu et al.   Molecular Cancer

Dexmedetomidine protects against cisplatin-induced acute kidney injury in mice through regulating apoptosis and inflammation

(2017) H. Liang et al.   INFLAMMATION RESEARCH

Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway

(2017) Ping Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dexmedetomidine preconditioning may attenuate myocardial ischemia/reperfusion injury by down-regulating the HMGB1-TLR4-MyD88-NF-кB signaling pathway

(2017) Jing-jing Zhang et al.   PLoS One

Antiphospholipid antibodies enhance rat neonatal cardiomyocyte apoptosis in an in vitro hypoxia/reoxygenation injury model via p38 MAPK

(2017) Lauren T Bourke et al.   Cell Death & Disease

Does remifentanil attenuate renal ischemia–reperfusion injury better than dexmedetomidine in rat kidney?

(2017) Ezgi Erkılıç et al.   Drug Design Development and Therapy

Knockdown of KLF11 attenuates hypoxia/reoxygenation injury via JAK2/STAT3 signaling in H9c2

(2016) Yang Li et al.   APOPTOSIS

Dexmedetomidine protects against lung ischemia–reperfusion injury by the PI3K/Akt/HIF-1α signaling pathway

(2016) Wei Zhang et al.   Journal of Anesthesia

Effects of Proanthocyanidins on Intestinal Motility Disturbance Following Intestinal Ischemia/Reperfusion

(2016) Lan Luo et al.   JOURNAL OF INVESTIGATIVE SURGERY

Effect of dexmedetomidine on cerebral ischemia-reperfusion rats by activating mitochondrial ATP-sensitive potassium channel

(2016) Feng Yuan et al.   METABOLIC BRAIN DISEASE

Brazilian green propolis induced apoptosis in human lung cancer A549 cells through mitochondrial-mediated pathway

(2015) Yahima Frión-Herrera et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Regulation of Bim in Health and Disease

(2015) Ronit Vogt Sionov et al.   Oncotarget

Dexmedetomidine Controls Systemic Cytokine Levels through the Cholinergic Anti-inflammatory Pathway

(2014) Hui Xiang et al.   INFLAMMATION

The Essential Role of p53-up-regulated Modulator of Apoptosis (Puma) and Its Regulation by FoxO3a Transcription Factor in β-Amyloid-induced Neuron Death

(2014) Rumana Akhter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Intravenous Infusion of Dexmedetomidine Combined with Inhalation of Isoflurane on Arterial Oxygenation and Intrapulmonary Shunt During Single-Lung Ventilation

(2013) Rui Xia et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

C1q/Tumor Necrosis Factor-Related Protein-9, a Novel Adipocyte-Derived Cytokine, Attenuates Adverse Remodeling in the Ischemic Mouse Heart via Protein Kinase A Activation

(2013) Y. Sun et al.   CIRCULATION

Ischemic Postconditioning-Mediated miRNA-21 Protects against Cardiac ischemia/reperfusion Injury via PTEN/Akt Pathway

(2013) Yingfeng Tu et al.   PLoS One

Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats

(2012) Yong-Man Zhu et al.   BRAIN RESEARCH

Puma Mediates the Apoptotic Signal of Hypoxia/Reoxygenation in Cardiomyocytes Through Mitochondrial Pathway

(2011) Yuzhen Li et al.   SHOCK

Dexmedetomidine in the Care of Critically Ill Patients from 2001 to 2007

(2010) Hannah Wunsch et al.   ANESTHESIOLOGY

Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance

(2010) Russell S. Whelan et al.   Annual Review of Physiology

β1-Integrin-Collagen Interaction Suppresses FoxO3a by the Coordination of Akt and PP2A

(2010) Richard Seonghun Nho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PUMA Induction by FoxO3a Mediates the Anticancer Activities of the Broad-Range Kinase Inhibitor UCN-01

(2010) C. Dudgeon et al.   MOLECULAR CANCER THERAPEUTICS

Potential Role of PUMA in Delayed Death of Hippocampal CA1 Neurons After Transient Global Cerebral Ischemia

(2008) Kuniyasu Niizuma et al.   STROKE