Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation

IL-21/IL-21R Signaling Aggravated Respiratory Inflammation Induced by Intracellular Bacteria through Regulation of CD4+ T Cell Subset Responses

(2021) Wenhao Niu et al.   JOURNAL OF IMMUNOLOGY

Ultrasound May Suppress Tumor Growth, Inhibit Inflammation, and Establish Tolerogenesis by Remodeling Innatome via Pathways of ROS, Immune Checkpoints, Cytokines, and Trained Immunity/Tolerance

(2021) Qian Yang et al.   Journal of Immunology Research

Tissue Treg Secretomes and Transcription Factors Shared With Stem Cells Contribute to a Treg Niche to Maintain Treg-Ness With 80% Innate Immune Pathways, and Functions of Immunosuppression and Tissue Repair

(2021) Ruijing Zhang et al.   Frontiers in Immunology

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis

(2021) Trevor P. Fidler et al.   NATURE

Targeting inflammation in atherosclerosis — from experimental insights to the clinic

(2021) Oliver Soehnlein et al.   NATURE REVIEWS DRUG DISCOVERY

Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways

(2021) Dong Ni et al.   Frontiers in Immunology

Platelet activation in critically ill COVID-19 patients

(2021) Nader Yatim et al.   Annals of Intensive Care

Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism

(2021) Ying Shao et al.   Frontiers in Immunology

Inhibition of Interleukin-21 prolongs the survival through the promotion of wound healing after myocardial infarction

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CEACAM1 promotes vascular aging processes

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Trained Immunity: An Underlying Driver of Inflammatory Atherosclerosis

(2020) Chao Zhong et al.   Frontiers in Immunology

End-stage renal disease is different from chronic kidney disease in upregulating ROS-modulated proinflammatory secretome in PBMCs - A novel multiple-hit model for disease progression

(2020) Ruijing Zhang et al.   Redox Biology

Vascular Endothelial Cells and Innate Immunity

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IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress

(2020) Zhenchuan Liu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting nuclear import and export in hematological malignancies

(2020) Boaz Nachmias et al.   LEUKEMIA

Approaching Inflammation Paradoxes—Proinflammatory Cytokine Blockages Induce Inflammatory Regulators

(2020) Ming Liu et al.   Frontiers in Immunology

Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis

(2020) Hangfei Fu et al.   Frontiers in Immunology

ROS systems are a new integrated network for sensing homeostasis and alarming stresses in organelle metabolic processes

(2020) Yu Sun et al.   Redox Biology

Trained Immunity and Reactivity of Macrophages and Endothelial Cells

(2020) Charles Drummer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The innate immune system and cell death in autoinflammatory and autoimmune disease

(2020) David E Place et al.   CURRENT OPINION IN IMMUNOLOGY

The Structure of the Nuclear Pore Complex (An Update)

(2019) Daniel H. Lin et al.   Annual Review of Biochemistry

CASP1 variants influence subcellular caspase-1 localization, pyroptosome formation, pro-inflammatory cell death and macrophage deformability

(2019) Franz Kapplusch et al.   CLINICAL IMMUNOLOGY

NLRP3, NLRP12, and IFI16 Inflammasomes Induction and Caspase-1 Activation Triggered by Virulent HSV-1 Strains Are Associated With Severe Corneal Inflammatory Herpetic Disease

(2019) Pierre-Gregoire Coulon et al.   Frontiers in Immunology

CXCL13 and Its Receptor CXCR5 in Cancer: Inflammation, Immune Response, and Beyond

(2019) Marcelo G. Kazanietz et al.   Frontiers in Endocrinology

Experimental Data-Mining Analyses Reveal New Roles of Low-Intensity Ultrasound in Differentiating Cell Death Regulatome in Cancer and Non-cancer Cells via Potential Modulation of Chromatin Long-Range Interactions

(2019) Jiwei Wang et al.   Frontiers in Oncology

miRNAs Identify Shared Pathways in Alzheimer’s and Parkinson’s Diseases

(2019) Angélique Sadlon et al.   TRENDS IN MOLECULAR MEDICINE

Atypical memory B-cells are associated with Plasmodium falciparum anemia through anti-phosphatidylserine antibodies

(2019) Juan Rivera-Correa et al.   eLife

Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors

(2019) Bin Lai et al.   Frontiers in Immunology

The IFITM protein family in adaptive immunity

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Anti-inflammatory cytokines IL-35 and IL-10 block atherogenic lysophosphatidylcholine-induced, mitochondrial ROS-mediated innate immune activation, but spare innate immune memory signature in endothelial cells

(2019) Xinyuan Li et al.   Redox Biology

Lysophospholipids and Their Receptors Serve as Conditional DAMPs and DAMP Receptors in Tissue Oxidative and Inflammatory Injury

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IL-35 (Interleukin-35) Suppresses Endothelial Cell Activation by Inhibiting Mitochondrial Reactive Oxygen Species-Mediated Site-Specific Acetylation of H3K14 (Histone 3 Lysine 14)Highlights

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Alterations in the nucleocytoplasmic transport in apoptosis: Caspases lead the way

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Uremic toxins are conditional danger- or homeostasis-associated molecular patterns

(2018) Rongshan Li   Frontiers in Bioscience-Landmark

Pioneer transcription factors shape the epigenetic landscape

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Lysophospholipids induce innate immune transdifferentiation of endothelial cells, resulting in prolonged endothelial activation

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DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses—Inflammations and Cancers Can Have High Genomic Risks

(2018) Huihong Zeng et al.   Frontiers in Physiology

GATA3, HDAC6, and BCL6 Regulate FOXP3+ Treg Plasticity and Determine Treg Conversion into Either Novel Antigen-Presenting Cell-Like Treg or Th1-Treg

(2018) Keman Xu et al.   Frontiers in Immunology

New human gene tally reignites debate

(2018) Cassandra Willyard   NATURE

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(2018) Evgeniia A. Prokhorova et al.   Scientific Reports

Anakinra Therapy for Non-cancer Inflammatory Diseases

(2018) Giulio Cavalli et al.   Frontiers in Pharmacology

Proton leak regulates mitochondrial reactive oxygen species generation in endothelial cell activation and inflammation - A novel concept

(2018) Gayani K. Nanayakkara et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

(2017) Ya-feng Li et al.   Journal of Hematology & Oncology

Global Characterization of Protein Secretion from Human Macrophages Following Non-canonical Caspase-4/5 Inflammasome Activation

(2017) Martina B. Lorey et al.   MOLECULAR & CELLULAR PROTEOMICS

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low-Intensity Ultrasound-Induced Anti-inflammatory Effects Are Mediated by Several New Mechanisms Including Gene Induction, Immunosuppressor Cell Promotion, and Enhancement of Exosome Biogenesis and Docking

(2017) Qian Yang et al.   Frontiers in Physiology

Inflammasomes are Differentially Expressed in Cardiovascular and other Tissues

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Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell ActivationHighlights

(2016) Xinyuan Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

(2016) Damien Bertheloot et al.   Cellular & Molecular Immunology

Chronic Kidney Disease Induces Inflammatory CD40 + Monocyte Differentiation via Homocysteine Elevation and DNA HypomethylationNovelty and Significance

(2016) Jiyeon Yang et al.   CIRCULATION RESEARCH

Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial CellsNovelty and Significance

(2016) Hang Xi et al.   CIRCULATION RESEARCH

The Emerging Role of Regucalcin as a Tumor Suppressor: Facts and Views

(2016) C. V. Vaz et al.   CURRENT MOLECULAR MEDICINE

Lymphocyte Antigen 75 Polymorphisms Are Associated with Disease Susceptibility and Phenotype in Japanese Patients with Inflammatory Bowel Disease

(2016) Atsuhiro Hirayama et al.   DISEASE MARKERS

Lysophospholipids and their G protein-coupled receptors in atherosclerosis

(2016) Rong-Shan Li   Frontiers in Bioscience-Landmark

Interleukin-17A Promotes Aortic Endothelial Cell Activation via Transcriptionally and Post-translationally Activating p38 Mitogen-activated Protein Kinase (MAPK) Pathway

(2016) Jietang Mai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymatically Inactive Procaspase 1 stabilizes the ASC Pyroptosome and Supports Pyroptosome Spreading during Cell Division

(2016) Robert Stein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-155 Deficiency Leads to Decreased Atherosclerosis, Increased White Adipose Tissue Obesity, and Non-alcoholic Fatty Liver Disease

(2016) Anthony Virtue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-penetrating peptides as noninvasive transmembrane vectors for the development of novel multifunctional drug-delivery systems

(2016) Dongdong Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study

(2016) Luqiao Wang et al.   Journal of Hematology & Oncology

Caspase-1 Plays a Critical Role in Accelerating Chronic Kidney Disease-Promoted Neointimal Hyperplasia in the Carotid Artery

(2016) Lucas M. Ferrer et al.   Journal of Cardiovascular Translational Research

Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation—Novel Paradigm and Therapeutic Potential

(2016) Xin Wang et al.   Journal of Cardiovascular Translational Research

DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota

(2016) Si Ming Man et al.   Pathogens and Disease

Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 PathwaySignificance

(2015) Ying Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer

(2015) M. Wang et al.   CANCER RESEARCH

Chronic kidney disease alters vascular smooth muscle cell phenotype

(2015) M Alexandra Monroy   Frontiers in Bioscience-Landmark

Inhibition of Caspase-1 Activation in Endothelial Cells Improves Angiogenesis

(2015) Jahaira Lopez-Pastrana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway

(2015) Xiaojin Sha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii

(2015) Daniel P. Beiting et al.   PLOS BIOLOGY

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Nuclear Factor E2-related Factor-2 (Nrf2) Is Required for NLRP3 and AIM2 Inflammasome Activation

(2014) Changcheng Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunosuppressive/anti-inflammatory cytokines directly and indirectly inhibit endothelial dysfunction- a novel mechanism for maintaining vascular function

(2014) Ying Shao et al.   Journal of Hematology & Oncology

Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate

(2014) A Aries et al.   Cell Death & Disease

Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility

(2013) Han Xiao et al.   CIRCULATION

Oxidative stress and vascular inflammation in aging

(2013) Mariam El Assar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inflammasomes: sensors of metabolic stresses for vascular inflammation 

(2013) Xiao-feng Yang   Frontiers in Bioscience-Landmark

An evolving new paradigm: endothelial cells – conditional innate immune cells

(2013) Jietang Mai et al.   Journal of Hematology & Oncology

Herpes Simplex Virus 1 Infection Induces Activation and Subsequent Inhibition of the IFI16 and NLRP3 Inflammasomes

(2013) K. E. Johnson et al.   JOURNAL OF VIROLOGY

Kaposi's Sarcoma-Associated Herpesvirus Latency in Endothelial and B Cells Activates Gamma Interferon-Inducible Protein 16-Mediated Inflammasomes

(2013) V. V. Singh et al.   JOURNAL OF VIROLOGY

Caspase-1 Promotes Epstein-Barr Virus Replication by Targeting the Large Tegument Protein Deneddylase to the Nucleus of Productively Infected Cells

(2013) Stefano Gastaldello et al.   PLoS Pathogens

Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal

(2011) Sunil K. George et al.   AGING CELL

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Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology: A novel target for antihypertensive agents

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Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes

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Caspase-1 recognizes extended cleavage sites in its natural substrates

(2009) Jerry Shen et al.   ATHEROSCLEROSIS

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Caspase-mediated Degradation of PPARγ Proteins in Adipocytes

(2008) Fang He et al.   Obesity