TNF and TNF receptors as therapeutic targets for rheumatic diseases and beyond

TNFR2 Depletion Reduces Psoriatic Inflammation in Mice by Downregulating Specific Dendritic Cell Populations in Lymph Nodes and Inhibiting IL-23/IL-17 Pathways

(2022) Unnikrishnan M. Chandrasekharan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Ozoralizumab, a Humanized Anti-TNFα NANOBODY® Compound, Exhibits Efficacy Not Only at the Onset of Arthritis in a Human TNF Transgenic Mouse but Also During Secondary Failure of Administration of an Anti-TNFα IgG

(2022) Chihiro Ishiwatari-Ogata et al.   Frontiers in Immunology

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(2022) Lisa Urquhart   NATURE REVIEWS DRUG DISCOVERY

TNFR2 is critical for TNF-induced rheumatoid arthritis fibroblast-like synoviocyte inflammation

(2022) Takahito Suto et al.   RHEUMATOLOGY

Targeting TNFR2: A Novel Breakthrough in the Treatment of Cancer

(2022) Muchun Li et al.   Frontiers in Oncology

NF-κB in control of regulatory T cell development, identity, and function

(2022) Nadine Hövelmeyer et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A TNFR2-Specific TNF Fusion Protein With Improved In Vivo Activity

(2022) Juan Gamboa Vargas et al.   Frontiers in Immunology

Tumor Necrosis Factor Receptor 2 (TNFR2): An Emerging Target in Cancer Therapy

(2022) Juliane Medler et al.   Cancers

A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer’s disease mouse model

(2022) Natalia Ortí-Casañ et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective inhibition of soluble tumor necrosis factor signaling reduces abdominal aortic aneurysm progression

(2022) Silke Griepke et al.   Frontiers in Cardiovascular Medicine

Effects of selective TNFR1 inhibition or TNFR2 stimulation, compared to non-selective TNF inhibition, on (neuro)inflammation and behavior after myocardial infarction in male mice

(2021) L. Gouweleeuw et al.   BRAIN BEHAVIOR AND IMMUNITY

Strategies to Target ADAM17 in Disease: From Its Discovery to the iRhom Revolution

(2021) Matteo Calligaris et al.   MOLECULES

Receptor Oligomerization and Its Relevance for Signaling by Receptors of the Tumor Necrosis Factor Receptor Superfamily

(2021) Kirstin Kucka et al.   Frontiers in Cell and Developmental Biology

Characterization of a TNFR2-Selective Agonistic TNF-α Mutant and Its Derivatives as an Optimal Regulatory T Cell Expander

(2021) Masaki Inoue et al.   JOURNAL OF IMMUNOLOGY

Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2–expressing Treg cells

(2021) Emilie Ronin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane lymphotoxin-α2β is a novel tumor necrosis factor (TNF) receptor 2 (TNFR2) agonist

(2021) Kirstin Kucka et al.   Cell Death & Disease

Selective inhibition of soluble TNF using XPro1595 relieves pain and attenuates cerulein-induced pathology in mice

(2021) Rajasa Randhi et al.   BMC GASTROENTEROLOGY

Insights into the biology and therapeutic implications of TNF and regulatory T cells

(2021) Benoit L. Salomon   Nature Reviews Rheumatology

The TNFR1 Antagonist Atrosimab Is Therapeutic in Mouse Models of Acute and Chronic Inflammation

(2021) Fabian Richter et al.   Frontiers in Immunology

Tumor necrosis factor receptor family co‐stimulation increases regulatory T cell activation and function via NF‐κB

(2020) Martina Lubrano di Ricco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells

(2020) Christos Karathanasis et al.   Science Signaling

Structural optimization of a TNFR1-selective antagonistic TNF-α mutant to create new-modality TNF-regulating biologics

(2020) Masaki Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative single‐molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα‐induced NF‐ĸB signaling

(2020) Nadine Weinelt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer’s disease in patients with rheumatoid arthritis and psoriasis

(2020) Mengshi Zhou et al.   PLoS One

TNFα/TNFR2 signaling pathway: an active immune checkpoint for mesenchymal stem cell immunoregulatory function

(2020) Ghada Beldi et al.   Stem Cell Research & Therapy

A systems-biology model of the tumor necrosis factor (TNF) interactions with TNF receptor 1 and 2

(2020) Juan Pablo Prada et al.   BIOINFORMATICS

Complexity of TNF-α Signaling in Heart Disease

(2020) Filip Rolski et al.   Journal of Clinical Medicine

TNFR2 Is a Crucial Hub Controlling Mesenchymal Stem Cell Biological and Functional Properties

(2020) Ghada Beldi et al.   Frontiers in Cell and Developmental Biology

TNFRSF receptor-specific antibody fusion proteins with targeting controlled FcγR-independent agonistic activity

(2019) Juliane Medler et al.   Cell Death & Disease

Tumor necrosis factor receptor-2 (TNFR2): an overview of an emerging drug target

(2019) Juliane Medler et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Improved monovalent TNF receptor 1-selective inhibitor with novel heterodimerizing Fc

(2019) Fabian Richter et al.   mAbs

Noncompetitive inhibitors of TNFR1 probe conformational activation states

(2019) Chih Hung Lo et al.   Science Signaling

TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages

(2019) Harald Wajant et al.   Frontiers in Cell and Developmental Biology

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

TNFR2 promotes Treg-mediated recovery from neuropathic pain across sexes

(2019) Roman Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF receptor 2 signaling prevents DNA methylation at the Foxp3 promoter and prevents pathogenic conversion of regulatory T cells

(2019) Wen-Yi Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNFR2 associates with FoxP3 stability and identifies asubset of regulatory T cells that are specifically expanded by anti‐TNF treatments in rheumatoid arthritis

(2019) François Santinon et al.   Arthritis & Rheumatology

TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity

(2019) Benjamin P. Hurrell et al.   Cell Reports

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling

(2018) Alice Borghi et al.   BIOCHEMICAL PHARMACOLOGY

Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice

(2018) Vanessa Lamontain et al.   Cellular & Molecular Immunology

A New Venue of TNF Targeting

(2018) Sophie Steeland et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury

(2018) Rachel K. Rowe et al.   Journal of Neuroinflammation

Novel anti-tumour necrosis factor receptor-1 (TNFR1) domain antibody prevents pulmonary inflammation in experimental acute lung injury

(2018) Alastair Proudfoot et al.   THORAX

IgG-single-chain TRAIL fusion proteins for tumour therapy

(2018) Martin Siegemund et al.   Scientific Reports

Selective Activation of Tumor Necrosis Factor Receptor II Induces Antiinflammatory Responses and Alleviates Experimental Arthritis

(2018) Roman Fischer et al.   Arthritis & Rheumatology

Lack of Evidence for a Direct Interaction of Progranulin and Tumor Necrosis Factor Receptor-1 and Tumor Necrosis Factor Receptor-2 From Cellular Binding Studies

(2018) Isabell Lang et al.   Frontiers in Immunology

Selective Modulation of TNF–TNFRs Signaling: Insights for Multiple Sclerosis Treatment

(2018) Valentina Pegoretti et al.   Frontiers in Immunology

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

(2018) Elodie Lafont et al.   NATURE CELL BIOLOGY

Discovery of Novel Ligands for TNF-α and TNF Receptor-1 through Structure-Based Virtual Screening and Biological Assay

(2017) Si Chen et al.   Journal of Chemical Information and Modeling

Can we design a better anti-cytokine therapy?

(2017) Marina S. Drutskaya et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Superior Properties of Fc-comprising scTRAIL Fusion Proteins

(2017) Meike Hutt et al.   MOLECULAR CANCER THERAPEUTICS

Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2

(2017) Roman Fischer et al.   Scientific Reports

Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation

(2017) Tobias Schmid et al.   Frontiers in Immunology

An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors

(2017) Chih Hung Lo et al.   SLAS Discovery

TNFR1 inhibition with a Nanobody protects against EAE development in mice

(2017) Sophie Steeland et al.   Scientific Reports

Treatment for Rheumatoid Arthritis and Risk of Alzheimer’s Disease: A Nested Case-Control Analysis

(2016) Richard C. Chou et al.   CNS DRUGS

Anti-TNF-α therapies for the treatment of Crohn’s disease: the past, present and future

(2016) Marc Berns et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Formation and removal of poly-ubiquitin chains in the regulation of tumor necrosis factor-induced gene activation and cell death

(2016) Sebastian Kupka et al.   FEBS Journal

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(2016) Martin Chopra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibiting tumor necrosis factor-α before amyloidosis prevents synaptic deficits in an Alzheimer's disease model

(2016) Chelsea Cavanagh et al.   NEUROBIOLOGY OF AGING

Cell-type–restricted anti-cytokine therapy: TNF inhibition from one pathogenic source

(2016) Grigory A. Efimov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration

(2016) Yun Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF and ROS Crosstalk in Inflammation

(2016) Heiko Blaser et al.   TRENDS IN CELL BIOLOGY

Inhibition of Soluble Tumor Necrosis Factor Prevents Chemically Induced Carcinogenesis in Mice

(2016) A. Sobo-Vujanovic et al.   Cancer Immunology Research

Specificity of human anti-variable heavy (VH) chain autoantibodies and impact on the design and clinical testing of a VHdomain antibody antagonist of tumour necrosis factor-α receptor 1

(2015) J. C. Cordy et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Targeting signaling factors for degradation, an emerging mechanism for TRAF functions

(2015) Xiao-Dong Yang et al.   IMMUNOLOGICAL REVIEWS

Dual Inhibition of TNFR1 and IFNAR1 in Imiquimod-Induced Psoriasiform Skin Inflammation in Mice

(2015) Lynda Grine et al.   JOURNAL OF IMMUNOLOGY

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation

(2015) J. L. Cueva Vargas et al.   JOURNAL OF NEUROSCIENCE

Infliximab efficacy in rheumatoid arthritis after an inadequate response to etanercept or adalimumab: results of a target-driven active switch study

(2014) Roy Fleischmann et al.   CURRENT MEDICAL RESEARCH AND OPINION

Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease

(2014) Han-Yun Hsiao et al.   HUMAN MOLECULAR GENETICS

Generation and Characterization of Small Single Domain Antibodies Inhibiting Human Tumor Necrosis Factor Receptor 1

(2014) Sophie Steeland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dendritic Cell Maturation and Survival Are Differentially Regulated by TNFR1 and TNFR2

(2014) Nicola J. Maney et al.   JOURNAL OF IMMUNOLOGY

Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia

(2014) Bettina Hjelm Clausen et al.   Journal of Neuroinflammation

Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice

(2014) Hans G Novrup et al.   Journal of Neuroinflammation

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells

(2014) Shawn A Mahmud et al.   NATURE IMMUNOLOGY

Tumor Necrosis Factor Suppresses NR5A2 Activity and Intestinal Glucocorticoid Synthesis to Sustain Chronic Colitis

(2014) S.-C. Huang et al.   Science Signaling

TNF and MAP kinase signalling pathways

(2014) Guadalupe Sabio et al.   SEMINARS IN IMMUNOLOGY

Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: a head-to-head phase 2 randomized controlled study (The ALTARA Study)

(2014) William P Kennedy et al.   ARTHRITIS RESEARCH & THERAPY

Progranulin does not inhibit TNF and lymphotoxin-α signalling through TNF receptor 1

(2013) Nima Etemadi et al.   IMMUNOLOGY AND CELL BIOLOGY

The Cytotoxic Effects of Certolizumab Pegol and Golimumab Mediated by Transmembrane Tumor Necrosis Factor α

(2013) Naoyasu Ueda et al.   INFLAMMATORY BOWEL DISEASES

Autoantibodies to Variable Heavy (VH) Chain Ig Sequences in Humans Impact the Safety and Clinical Pharmacology of a VH Domain Antibody Antagonist of TNF-α Receptor 1

(2013) M. C. Holland et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Transmembrane TNF-  Promotes Suppressive Activities of Myeloid-Derived Suppressor Cells via TNFR2

(2013) X. Hu et al.   JOURNAL OF IMMUNOLOGY

TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis

(2013) Clemens Duerrschmid et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells

(2013) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Both Internalization and AIP1 Association Are Required for Tumor Necrosis Factor Receptor 2-Mediated JNK Signaling

(2012) Weidong Ji et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CD27 Signaling Increases the Frequency of Regulatory T Cells and Promotes Tumor Growth

(2012) C. Claus et al.   CANCER RESEARCH

IAPs limit activation of RIP kinases by TNF receptor 1 during development

(2012) Maryline Moulin et al.   EMBO JOURNAL

TNF signaling drives myeloid-derived suppressor cell accumulation

(2012) Xueqiang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

c-FLIP Maintains Tissue Homeostasis by Preventing Apoptosis and Programmed Necrosis

(2012) X. Piao et al.   Science Signaling

Allergic Lung Inflammation Is Mediated by Soluble Tumor Necrosis Factor (TNF) and Attenuated by Dominant-Negative TNF Biologics

(2011) Isabelle Maillet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination

(2011) Roberta Brambilla et al.   BRAIN

Targeting pre-ligand assembly domain of TNFR1 ameliorates autoimmune diseases – An unrevealed role in downregulation of Th17 cells

(2011) Yen-Ling Wang et al.   JOURNAL OF AUTOIMMUNITY

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Targeted tumor necrosis factor receptor I preligand assembly domain improves skin lesions in MRL/lpr mice

(2010) Guo-Min Deng et al.   ARTHRITIS AND RHEUMATISM

Lymphotoxin-αβ heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis

(2010) Judy Young et al.   CYTOKINE

Lymphotoxin α stimulates proliferation and pro-inflammatory cytokine secretion of rheumatoid arthritis synovial fibroblasts

(2010) Flavia Calmon-Hamaty et al.   CYTOKINE

ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor one-specific antibody

(2010) Kirstin A. Zettlitz et al.   mAbs

Solution of the Structure of the TNF-TNFR2 Complex

(2010) Y. Mukai et al.   Science Signaling

The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis

(2010) P. Vandenabeele et al.   Science Signaling

The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF

(2009) Hiroko Shibata et al.   BIOMATERIALS

Soluble lymphotoxin is an important effector molecule in GVHD and GVL

(2009) K. A. Markey et al.   BLOOD

Effectiveness and safety of etanercept in subjects with RA who have failed infliximab therapy: 16-week, open-label, observational study

(2009) Clifton O. Bingham et al.   CURRENT MEDICAL RESEARCH AND OPINION

Differences in binding and effector functions between classes of TNF antagonists

(2009) Taruna Arora et al.   CYTOKINE

TNFα shedding and epidermal inflammation are controlled by Jun proteins

(2009) Juan Guinea-Viniegra et al.   GENES & DEVELOPMENT

Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2)

(2009) Hilka Rauert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice

(2009) Tetsuya Nomura et al.   JOURNAL OF CONTROLLED RELEASE

Dominant‐Negative Tumor Necrosis Factor Protects fromMycobacterium bovisBacillus Calmette‐Guérin (BCG) and Endotoxin‐Induced Liver Injury without Compromising Host Immunity to BCG andMycobacterium tuberculosis

(2009) Maria L. Olleros et al.   JOURNAL OF INFECTIOUS DISEASES

Mechanisms for cytotoxic effects of anti–tumor necrosis factor agents on transmembrane tumor necrosis factor α–expressing cells: Comparison among infliximab, etanercept, and adalimumab

(2008) Hiroki Mitoma et al.   ARTHRITIS AND RHEUMATISM

TL1A Both Promotes and Protects from Renal Inflammation and Injury

(2008) R. S. Al-Lamki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY