Autoantibodies to Variable Heavy (VH) Chain Ig Sequences in Humans Impact the Safety and Clinical Pharmacology of a VH Domain Antibody Antagonist of TNF-α Receptor 1

Human Anti-IgG1 Hinge Autoantibodies Reconstitute the Effector Functions of Proteolytically Inactivated IgGs

(2014) R. J. Brezski et al.   JOURNAL OF IMMUNOLOGY

ATROSAB, a humanized antagonistic anti-tumor necrosis factor receptor one-specific antibody

(2010) Kirstin A. Zettlitz et al.   mAbs

Cleavage of IgGs by proteases associated with invasive diseases

(2010) Randall J. Brezski et al.   mAbs

B-1 cells and naturally occurring antibodies: influencing the immunogenicity of recombinant human therapeutic proteins?

(2009) Melody Sauerborn et al.   CURRENT OPINION IN BIOTECHNOLOGY

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

(2009) R. J. Brezski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human F(ab′)2-containing immune complexes together with anti-hinge natural antibodies stimulate complement amplification in vitro and in vivo

(2008) Sandra Fumia et al.   MOLECULAR IMMUNOLOGY

Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose

(2008) Christine H. Chung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic cleavage of IgG is dangerous in humans

(2008) Hans U. Lutz et al.   TRENDS IN IMMUNOLOGY

Naturally occurring auto-antibodies in homeostasis and disease

(2008) Hans U. Lutz et al.   TRENDS IN IMMUNOLOGY