Lack of Evidence for a Direct Interaction of Progranulin and Tumor Necrosis Factor Receptor-1 and Tumor Necrosis Factor Receptor-2 From Cellular Binding Studies

Progranulin, lysosomal regulation and neurodegenerative disease

(2017) Aimee W. Kao et al.   NATURE REVIEWS NEUROSCIENCE

Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia

(2017) Grietje Krabbe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer

(2017) Linlin Wang et al.   Oncotarget

Progranulin inhibits expression and release of chemokines CXCL9 and CXCL10 in a TNFR1 dependent manner

(2016) Jyoti Joshi Mundra et al.   Scientific Reports

Progranulin plays crucial roles in preserving bone mass by inhibiting TNF-α-induced osteoclastogenesis and promoting osteoblastic differentiation in mice

(2015) Takaaki Noguchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The molecular basis for development of proinflammatory autoantibodies to progranulin

(2015) Lorenz Thurner et al.   JOURNAL OF AUTOIMMUNITY

Binding Studies of TNF Receptor Superfamily (TNFRSF) Receptors on Intact Cells

(2015) Isabell Lang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New discovery rarely runs smooth: an update on progranulin/TNFR interactions

(2015) Betty C. Wang et al.   Protein & Cell

Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling

(2014) Yun-peng Zhao et al.   ANNALS OF THE RHEUMATIC DISEASES

Progranulin shows cytoprotective effects on trophoblast cells in vitro but does not antagonize TNF-α-induced apoptosis

(2014) Johannes Stubert et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Three TNFR-binding domains of PGRN act independently in inhibition of TNF-alpha binding and activity

(2014) Qingyun Tian   Frontiers in Bioscience-Landmark

Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4+ Foxp3+regulatory T cells

(2014) Ya Hu et al.   IMMUNOLOGY

Increased Serum GP88 (Progranulin) Concentrations in Rheumatoid Arthritis

(2014) Yasuko Yamamoto et al.   INFLAMMATION

The promotion of bone healing by progranulin, a downstream molecule of BMP-2, through interacting with TNF/TNFR signaling

(2013) Yun-peng Zhao et al.   BIOMATERIALS

Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice

(2013) Ryota Kawase et al.   CARDIOVASCULAR RESEARCH

Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains

(2013) Jinlong Jian et al.   FEBS LETTERS

Progranulin does not inhibit TNF and lymphotoxin-α signalling through TNF receptor 1

(2013) Nima Etemadi et al.   IMMUNOLOGY AND CELL BIOLOGY

The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment

(2013) Yusuke Egashira et al.   Journal of Neuroinflammation

Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells

(2013) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Signaling Active CD95 Receptor Molecules Trigger Co-translocation of Inactive CD95 Molecules into Lipid Rafts

(2012) Isabell Lang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration

(2012) Basar Cenik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Studies of Binding of Tumor Necrosis Factor (TNF)-like Weak Inducer of Apoptosis (TWEAK) to Fibroblast Growth Factor Inducible 14 (Fn14)

(2011) Andrea Fick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Solution of the Structure of the TNF-TNFR2 Complex

(2010) Y. Mukai et al.   Science Signaling