An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors

Open and Closed Conformations of the Isolated Transmembrane Domain of Death Receptor 5 Support a New Model of Activation

(2014) Andrew K. Lewis et al.   BIOPHYSICAL JOURNAL

Quantitative single-molecule localization microscopy combined with rule-based modeling reveals ligand-induced TNF-R1 reorganization toward higher-order oligomers

(2014) Franziska Fricke et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Fluorescence lifetime plate reader: Resolution and precision meet high-throughput

(2014) Karl J. Petersen et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

TNFR1 Signaling Is Associated with Backbone Conformational Changes of Receptor Dimers Consistent with Overactivation in the R92Q TRAPS Mutant

(2012) Andrew K. Lewis et al.   BIOCHEMISTRY

Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Induces Death Receptor 5 Networks That Are Highly Organized

(2012) Christopher C. Valley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variability in docking success rates due to dataset preparation

(2012) Christopher R. Corbeil et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

TNFR1-induced activation of the classical NF-κB pathway

(2011) Harald Wajant et al.   FEBS Journal

Thermodynamics-based drug design: strategies for inhibiting protein–protein interactions

(2011) Arne Schön et al.   Future Medicinal Chemistry

Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action

(2010) Susanne C. Miller et al.   BIOCHEMICAL PHARMACOLOGY

Some Binding-Related Drug Properties are Dependent on Thermodynamic Signature

(2010) Arne Schön et al.   Chemical Biology & Drug Design

Cholangiocarcinoma: New Insights into Disease Pathogenesis and Biology

(2010) Chiara Braconi et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

High-performance time-resolved fluorescence by direct waveform recording

(2010) Joseph M. Muretta et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor

(2009) M. Vilar et al.   JOURNAL OF CELL SCIENCE

Activation of the p75 Neurotrophin Receptor through Conformational Rearrangement of Disulphide-Linked Receptor Dimers

(2009) Marçal Vilar et al.   NEURON

The generalized Born/volume integral implicit solvent model: Estimation of the free energy of hydration using London dispersion instead of atomic surface area

(2008) Paul Labute   JOURNAL OF COMPUTATIONAL CHEMISTRY

Tumor necrosis factor antagonist mechanisms of action: A comprehensive review

(2007) Daniel Tracey et al.   PHARMACOLOGY & THERAPEUTICS