Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation

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The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease

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Ketone Body 3‐Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a‐Mediated Calcium Influx

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Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery

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Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor

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Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1

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β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

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An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor

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Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode

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The operational model of allosteric modulation of pharmacological agonism

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Lactate-induced activation of HCA2 improves survival in mice with sepsis

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Mechanism of β2AR regulation by an intracellular positive allosteric modulator

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Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

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β-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway

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Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS

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Nutritional or pharmacological activation of HCA2 ameliorates neuroinflammation

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GPR109a: The Missing Link between Microbiome and Good Health?

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Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

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