GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors

Structural insights into the human D1 and D2 dopamine receptor signaling complexes

(2021) Youwen Zhuang et al.   CELL

Structures of the human dopamine D3 receptor-Gi complexes

(2021) Peiyu Xu et al.   MOLECULAR CELL

Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

(2021) Chuan Hong et al.   Nature Communications

Structural insights into the lipid and ligand regulation of serotonin receptors

(2021) Peiyu Xu et al.   NATURE

Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling

(2021) Hadar Israeli et al.   SCIENCE

Cryo-EM structure of the human histamine H1 receptor/Gq complex

(2021) Ruixue Xia et al.   Nature Communications

DeepEMhancer: a deep learning solution for cryo-EM volume post-processing

(2021) Ruben Sanchez-Garcia et al.   Communications Biology

The IUPHAR/BPS guide to PHARMACOLOGY in 2022: curating pharmacology for COVID-19, malaria and antibacterials

(2021) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures

(2020) Tian Hua et al.   CELL

Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex

(2020) Changrui Xing et al.   CELL

Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation

(2020) Yi-Lynn Liang et al.   MOLECULAR CELL

Structural basis of ligand recognition and self-activation of orphan GPR52

(2020) Xi Lin et al.   NATURE

Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling

(2020) Youwen Zhuang et al.   Nature Communications

Activation of the α2B adrenoceptor by the sedative sympatholytic dexmedetomidine

(2020) Daopeng Yuan et al.   Nature Chemical Biology

Cryo-EM structures of inactive and active GABAB receptor

(2020) Chunyou Mao et al.   CELL RESEARCH

Structural basis of GPBAR activation and bile acid recognition

(2020) Fan Yang et al.   NATURE

Structural basis of CXC chemokine receptor 2 activation and signalling

(2020) Kaiwen Liu et al.   NATURE

Central 5-HT receptors and their function; present and future

(2020) Trevor Sharp et al.   NEUROPHARMACOLOGY

Structural insights into differences in G protein activation by family A and family B GPCRs

(2020) Daniel Hilger et al.   SCIENCE

Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20

(2020) David Jonathan Wasilko et al.   Nature Communications

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

(2020) Kuglae Kim et al.   CELL

Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists

(2020) Xin Zhang et al.   MOLECULAR CELL

Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor

(2020) Minfei Su et al.   MOLECULAR CELL

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

GPCRdb in 2021: integrating GPCR sequence, structure and function

(2020) Albert J Kooistra et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein

(2020) Shingo Nojima et al.   STRUCTURE

OPLS3e: Extending Force Field Coverage for Drug-Like Small Molecules

(2019) Katarina Roos et al.   Journal of Chemical Theory and Computation

Ligand-induced activation of ERK1/2 signaling by constitutively active Gs-coupled 5-HT receptors

(2019) Ping Liu et al.   ACTA PHARMACOLOGICA SINICA

Assembly of a GPCR-G Protein Complex

(2019) Yang Du et al.   CELL

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes

(2019) Shoji Maeda et al.   SCIENCE

Illuminating G-Protein-Coupling Selectivity of GPCRs

(2019) Asuka Inoue et al.   CELL

Conformational transitions of a neurotensin receptor 1–Gi1 complex

(2019) Hideaki E. Kato et al.   NATURE

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

(2018) Javier García-Nafría et al.   eLife

Cryo-EM structure of human rhodopsin bound to an inhibitory G protein

(2018) Yanyong Kang et al.   NATURE

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

(2018) Christopher J. Draper-Joyce et al.   NATURE

How the ubiquitous GPCR receptor family selectively activates signalling pathways

(2018) Michael J. Capper et al.   NATURE

Cryo-EM structure of the serotonin 5-HT1B receptor coupled to heterotrimeric Go

(2018) Javier García-Nafría et al.   NATURE

Structure of the µ-opioid receptor–Gi protein complex

(2018) Antoine Koehl et al.   NATURE

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

(2018) Shoji Maeda et al.   Nature Communications

Aminergic GPCR–Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data

(2018) Márton Vass et al.   JOURNAL OF MEDICINAL CHEMISTRY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Selectivity determinants of GPCR–G-protein binding

(2017) Tilman Flock et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer

(2016) Ping Liu et al.   ACTA PHARMACOLOGICA SINICA

GPCRdb: the G protein-coupled receptor database - an introduction

(2016) C Munk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

GPCRdb: an information system for G protein-coupled receptors

(2016) Vignir Isberg et al.   NUCLEIC ACIDS RESEARCH

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

(2015) Andrew S. Dixon et al.   ACS Chemical Biology

Universal allosteric mechanism for Gα activation by GPCRs

(2015) Tilman Flock et al.   NATURE

JPred4: a protein secondary structure prediction server

(2015) Alexey Drozdetskiy et al.   NUCLEIC ACIDS RESEARCH

Generic GPCR residue numbers – aligning topology maps while minding the gaps

(2015) Vignir Isberg et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

(2013) G. Madhavi Sastry et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

GPCRDB: an information system for G protein-coupled receptors

(2013) Vignir Isberg et al.   NUCLEIC ACIDS RESEARCH

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors

(2012) Eugene Chun et al.   STRUCTURE

Improved Treatment of Ligands and Coupling Effects in Empirical Calculation and Rationalization of pKaValues

(2011) Chresten R. Søndergaard et al.   Journal of Chemical Theory and Computation

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

New-generation 5-HT4 receptor agonists: potential for treatment of gastrointestinal motility disorders

(2010) Noriaki Manabe et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Towards the comprehensive, rapid, and accurate prediction of the favorable tautomeric states of drug-like molecules in aqueous solution

(2010) Jeremy R. Greenwood et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Expanded Biology of Serotonin

(2009) Miles Berger et al.   Annual Review of Medicine

Serotonin Receptors

(2008) David E. Nichols et al.   CHEMICAL REVIEWS