Molecular recognition of morphine and fentanyl by the human μ-opioid receptor

Structural Assessment of Agonist Efficacy in the μ-Opioid Receptor: Morphine and Fentanyl Elicit Different Activation Patterns

(2021) Adrián Ricarte et al.   Journal of Chemical Information and Modeling

Structural insights into the human D1 and D2 dopamine receptor signaling complexes

(2021) Youwen Zhuang et al.   CELL

How μ-opioid receptor recognizes fentanyl

(2021) Quynh N. Vo et al.   Nature Communications

Trends and Geographic Patterns in Drug and Synthetic Opioid Overdose Deaths — United States, 2013–2019

(2021) Christine L. Mattson et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Structural insights into the lipid and ligand regulation of serotonin receptors

(2021) Peiyu Xu et al.   NATURE

Biased ligands at opioid receptors: Current status and future directions

(2021) Tao Che et al.   Science Signaling

The anomalous pharmacology of fentanyl

(2021) Eamonn Kelly et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular insights into the biased signaling mechanism of the μ-opioid receptor

(2021) Xiaojing Cong et al.   MOLECULAR CELL

Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor

(2021) Qiufeng Liu et al.   Nature Chemical Biology

DeepEMhancer: a deep learning solution for cryo-EM volume post-processing

(2021) Ruben Sanchez-Garcia et al.   Communications Biology

Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1

(2021) Zhehua Shao et al.   Nature Chemical Biology

Structural basis of sphingosine-1-phosphate receptor 1 activation and biased agonism

(2021) Zhenmei Xu et al.   Nature Chemical Biology

Morphine‐induced respiratory depression is independent of β‐arrestin2 signalling

(2020) Andrea Kliewer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

(2020) Weijiao Huang et al.   NATURE

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

(2020) Dean P. Staus et al.   NATURE

Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling

(2020) Youwen Zhuang et al.   Nature Communications

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

(2020) Alexander Gillis et al.   Science Signaling

Molecular mechanisms of fentanyl mediated β-arrestin biased signaling

(2020) Parker W. de Waal et al.   PLoS Computational Biology

DARK Classics in Chemical Neuroscience: Carfentanil

(2020) Anna E Ringuette et al.   ACS Chemical Neuroscience

CHARMM-GUI supports the Amber force fields

(2020) Jumin Lee et al.   JOURNAL OF CHEMICAL PHYSICS

Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor

(2020) Yang Lee et al.   NATURE

Affinity, potency, efficacy, selectivity, and molecular modeling of substituted fentanyls at opioid receptors

(2020) Amy J. Eshleman et al.   BIOCHEMICAL PHARMACOLOGY

A fast and high-quality charge model for the next generation general AMBER force field

(2020) Xibing He et al.   JOURNAL OF CHEMICAL PHYSICS

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy

(2020) Jia Duan et al.   Nature Communications

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations

(2019) Laura M. Wingler et al.   CELL

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

(2019) A. Kliewer et al.   Nature Communications

APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy

(2019) Eugene R Viscusi et al.   Journal of Pain Research

Molecular dynamics of fentanyl bound to μ-opioid receptor

(2019) Piotr F. J. Lipiński et al.   JOURNAL OF MOLECULAR MODELING

APOLLO ‐2: A Randomized, Placebo and Active‐Controlled Phase III Study Investigating Oliceridine ( TRV 130), a G Protein‐Biased Ligand at the μ‐Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty

(2019) Neil K. Singla et al.   Pain Practice

Molecular basis of opioid action: from structures to new leads

(2019) Aashish Manglik   BIOLOGICAL PSYCHIATRY

Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists

(2019) Tobias Claff et al.   Science Advances

ff19SB: Amino-Acid-Specific Protein Backbone Parameters Trained against Quantum Mechanics Energy Surfaces in Solution

(2019) Chuan Tian et al.   Journal of Chemical Theory and Computation

DARK Classics in Chemical Neuroscience: Fentanyl

(2018) S. Mallory Burns et al.   ACS Chemical Neuroscience

The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception

(2018) Rob Hill et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

(2018) Tao Che et al.   CELL

Structure of the µ-opioid receptor–Gi protein complex

(2018) Antoine Koehl et al.   NATURE

Structural determinants of 5-HT2B receptor activation and biased agonism

(2018) John D. McCorvy et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Development of an antibody fragment that stabilizes GPCR/G-protein complexes

(2018) Shoji Maeda et al.   Nature Communications

Aminergic GPCR–Ligand Interactions: A Chemical and Structural Map of Receptor Mutation Data

(2018) Márton Vass et al.   JOURNAL OF MEDICINAL CHEMISTRY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Fatalities Involving Carfentanil and Furanyl Fentanyl: Two Case Reports

(2017) Dina M. Swanson et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse liability in rodents

(2017) Ahmad A Altarifi et al.   JOURNAL OF PSYCHOPHARMACOLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Residues W320 and Y328 within the binding site of the μ-opioid receptor influence opiate ligand bias

(2017) J. Daniel Hothersall et al.   NEUROPHARMACOLOGY

Designing Safer Analgesics via μ-Opioid Receptor Pathways

(2017) H.C. Stephen Chan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer

(2016) Ping Liu et al.   ACTA PHARMACOLOGICA SINICA

G-protein–gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids

(2016) Gaspard Montandon et al.   ANESTHESIOLOGY

CHARMM-GUI 10 years for biomolecular modeling and simulation

(2016) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Structure-based discovery of opioid analgesics with reduced side effects

(2016) Aashish Manglik et al.   NATURE

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

μ opioid receptor activation hyperpolarizes respiratory-controlling Kölliker-Fuse neurons and suppresses post-inspiratory drive

(2015) Erica S. Levitt et al.   JOURNAL OF PHYSIOLOGY-LONDON

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structural insights into µ-opioid receptor activation

(2015) Weijiao Huang et al.   NATURE

Stabilization of G protein-coupled receptors by point mutations

(2015) Franziska M. Heydenreich et al.   Frontiers in Pharmacology

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data

(2013) Daniel R. Roe et al.   Journal of Chemical Theory and Computation

Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain

(2013) Xiao-Tao Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Structure of the δ-opioid receptor bound to naltrindole

(2012) Sébastien Granier et al.   NATURE

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic

(2012) Aaron A. Thompson et al.   NATURE

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

Molecular Mechanisms of Opioid Receptor-dependent Signaling and Behavior

(2011) Ream Al-Hasani et al.   ANESTHESIOLOGY

MDpocket: open-source cavity detection and characterization on molecular dynamics trajectories

(2011) Peter Schmidtke et al.   BIOINFORMATICS

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY