The operational model of allosteric modulation of pharmacological agonism

Allosteric drugs and mutations: chances, challenges, and necessity

(2020) Enrico Guarnera et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Recent advances suggest increased influence of selective pressure in allostery

(2020) Archana S Bhat et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Allostery in Its Many Disguises: From Theory to Applications

(2019) Shoshana J. Wodak et al.   STRUCTURE

Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators

(2019) Jan Jakubík et al.   PLoS One

The δ‐opioid receptor positive allosteric modulator BMS 986187 is a G‐protein‐biased allosteric agonist

(2019) M. Alexander Stanczyk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Intrinsic dynamics is evolutionarily optimized to enable allosteric behavior

(2019) Yan Zhang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors

(2018) Wessel A.C. Burger et al.   JOURNAL OF GENERAL PHYSIOLOGY

Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts

(2018) Eric A. Wold et al.   JOURNAL OF MEDICINAL CHEMISTRY

On the perturbation nature of allostery: sites, mutations, and signal modulation

(2018) Enrico Guarnera et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders

(2017) Daniel J. Foster et al.   NEURON

Allostery: An Overview of Its History, Concepts, Methods, and Applications

(2016) Jin Liu et al.   PLoS Computational Biology

Novel Allosteric Agonists of M1 Muscarinic Acetylcholine Receptors Induce Brain Region-Specific Responses That Correspond with Behavioral Effects in Animal Models

(2012) G. J. Digby et al.   JOURNAL OF NEUROSCIENCE

Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Differentially Regulates Orthosteric but Not Allosteric Agonist Binding and Function

(2011) Cassandra Koole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative cooperativity in binding of muscarinic receptor agonists and GDP as a measure of agonist efficacy

(2010) J Jakubík et al.   BRITISH JOURNAL OF PHARMACOLOGY

Allosteric ligands for G protein-coupled receptors: A novel strategy with attractive therapeutic opportunities

(2009) Marco De Amici et al.   MEDICINAL RESEARCH REVIEWS

Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties

(2008) Thomas M. Bridges et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS