Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode

Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures

(2020) Tian Hua et al.   CELL

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex

(2019) Kaavya Krishna Kumar et al.   CELL

Diverse GPCRs exhibit conserved water networks for stabilization and activation

(2019) A. J. Venkatakrishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relugolix: First Global Approval

(2019) Anthony Markham   DRUGS

Conformational transitions of a neurotensin receptor 1–Gi1 complex

(2019) Hideaki E. Kato et al.   NATURE

Structure of an allosteric modulator bound to the CB1 cannabinoid receptor

(2019) Zhenhua Shao et al.   Nature Chemical Biology

Common activation mechanism of class A GPCRs

(2019) Qingtong Zhou et al.   eLife

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

Elagolix: First Global Approval

(2018) Yvette N. Lamb   DRUGS

Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor

(2018) Ryoji Suno et al.   Nature Chemical Biology

Successes and failures of uterine leiomyoma drug discovery

(2017) Mohamed Ali et al.   Expert Opinion on Drug Discovery

Efficacy of elagolix in the treatment of endometriosis

(2017) Alexandra Perricos et al.   EXPERT OPINION ON PHARMACOTHERAPY

Recent Development of Non-Peptide GnRH Antagonists

(2017) Feng-Ling Tukun et al.   MOLECULES

Discovery of LHRH and development of LHRH analogs for prostate cancer treatment

(2017) Andrew V. Schally et al.   PROSTATE

Ligand modulation of sidechain dynamics in a wild-type human GPCR

(2017) Lindsay D Clark et al.   eLife

The Role of Gonadotropin-Releasing Hormone in Cancer Cell Proliferation and Metastasis

(2017) Carsten Gründker et al.   Frontiers in Endocrinology

Gonadotropin-Releasing Hormone (GnRH) Receptor Structure and GnRH Binding

(2017) Colleen A. Flanagan et al.   Frontiers in Endocrinology

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

Discovery of an Orally Bioavailable Gonadotropin-Releasing Hormone Receptor Antagonist

(2016) Seon-Mi Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

High-resolution crystal structure of the human CB1 cannabinoid receptor

(2016) Zhenhua Shao et al.   NATURE

GnRH and GnRH receptors in the pathophysiology of the human female reproductive system

(2015) Roberto Maggi et al.   HUMAN REPRODUCTION UPDATE

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field

(2015) Jumin Lee et al.   Journal of Chemical Theory and Computation

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

(2015) L. Qin et al.   SCIENCE

Oxime bond-linked daunorubicin-GnRH-III bioconjugates exert antitumor activity in castration-resistant prostate cancer cells via the type I GnRH receptor

(2014) MARINA MONTAGNANI MARELLI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CHARMM-GUIMembrane Buildertoward realistic biological membrane simulations

(2014) Emilia L. Wu et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

(2014) Jie Yin et al.   NATURE

Gonadotropin-releasing hormone receptors as molecular therapeutic targets in prostate cancer: Current options and emerging strategies

(2013) Patrizia Limonta et al.   CANCER TREATMENT REVIEWS

CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

(2013) Jing Huang et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Molecular Mechanisms of Gonadotropin-Releasing Hormone Signaling: Integrating Cyclic Nucleotides into the Network

(2013) Rebecca M. Perrett et al.   Frontiers in Endocrinology

GnRH Receptors in Cancer: From Cell Biology to Novel Targeted Therapeutic Strategies

(2012) Patrizia Limonta et al.   ENDOCRINE REVIEWS

Lipidic cubic phase technologies for membrane protein structural studies

(2011) Vadim Cherezov   CURRENT OPINION IN STRUCTURAL BIOLOGY

Role of the Transmembrane Domain 4/Extracellular Loop 2 Junction of the Human Gonadotropin-releasing Hormone Receptor in Ligand Binding and Receptor Conformational Selection

(2011) Rachel Forfar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Equilibrium Between the Octahedral and Square Pyramidal Form and the Influence of an Axial Ligand on the Molecular Properties of VIVO Complexes: A Spectroscopic and DFT Study

(2010) Serge Gorelsky et al.   CHEMISTRY-A EUROPEAN JOURNAL

GnRH signaling, the gonadotrope and endocrine control of fertility

(2010) Stuart P. Bliss et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Agonist-induced internalization and downregulation of gonadotropin-releasing hormone receptors

(2009) Ann R. Finch et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Type I Gonadotropin-Releasing Hormone Receptor Mediates the Antiproliferative Effects of GnRH-II on Prostate Cancer Cells

(2009) Marina Montagnani Marelli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Crystallizing membrane proteins using lipidic mesophases

(2009) Martin Caffrey et al.   Nature Protocols

Human gonadotropin-releasing hormone receptor-activated cellular functions and signaling pathways in extra-pituitary tissues and cancer cells (Review)

(2009) Aguilar-Rojas   ONCOLOGY REPORTS

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY