Structure of an allosteric modulator bound to the CB1 cannabinoid receptor
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Structure of an allosteric modulator bound to the CB1 cannabinoid receptor
Authors
Keywords
-
Journal
Nature Chemical Biology
Volume 15, Issue 12, Pages 1199-1205
Publisher
Springer Science and Business Media LLC
Online
2019-10-29
DOI
10.1038/s41589-019-0387-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
- (2019) Kaavya Krishna Kumar et al. CELL
- Orthosteric and allosteric action of the C5a receptor antagonists
- (2018) Heng Liu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Orthosteric and allosteric action of the C5a receptor antagonists
- (2018) Heng Liu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural insights into G-protein-coupled receptor allostery
- (2018) David M. Thal et al. NATURE
- New approaches and challenges to targeting the endocannabinoid system
- (2018) Vincenzo Di Marzo NATURE REVIEWS DRUG DISCOVERY
- Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor
- (2018) Ryoji Suno et al. Nature Chemical Biology
- Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure
- (2017) Xiangyu Liu et al. NATURE
- Crystal structures of agonist-bound human cannabinoid receptor CB1
- (2017) Tian Hua et al. NATURE
- Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40
- (2017) Jun Lu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities
- (2017) Leepakshi Khurana et al. NEUROPHARMACOLOGY
- Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome
- (2017) Orrin Devinsky et al. NEW ENGLAND JOURNAL OF MEDICINE
- Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40
- (2017) Jun Lu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Crystal Structure of the Human Cannabinoid Receptor CB 1
- (2016) Tian Hua et al. CELL
- Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists
- (2016) Yi Zheng et al. NATURE
- High-resolution crystal structure of the human CB1 cannabinoid receptor
- (2016) Zhenhua Shao et al. NATURE
- Manipulation of Subunit Stoichiometry in Heteromeric Membrane Proteins
- (2016) Claudio L. Morales-Perez et al. STRUCTURE
- Cannabinoids for Medical Use
- (2015) Penny F. Whiting et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)
- (2015) Pushkar M. Kulkarni et al. JOURNAL OF MEDICINAL CHEMISTRY
- Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
- (2015) Yanyong Kang et al. NATURE
- Structural dynamics and energetics underlying allosteric inactivation of the cannabinoid receptor CB1
- (2015) Jonathan F. Fay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Endogenous vs Exogenous Allosteric Modulators in GPCRs: A dispute for shuttling CB1 among different membrane microenvironments
- (2015) Mariano Stornaiuolo et al. Scientific Reports
- Pregnenolone Can Protect the Brain from Cannabis Intoxication
- (2014) Monique Vallée et al. SCIENCE
- Allosteric Modulation of a Cannabinoid G Protein-coupled Receptor
- (2013) Derek M. Shore et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)
- (2013) Kwang H. Ahn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation and allosteric modulation of a muscarinic acetylcholine receptor
- (2013) Andrew C. Kruse et al. NATURE
- The Endocannabinoid System and the Brain
- (2012) Raphael Mechoulam et al. Annual Review of Psychology
- Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?
- (2012) Javier Fernández-Ruiz et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- A Key Agonist-induced Conformational Change in the Cannabinoid Receptor CB1 Is Blocked by the Allosteric Ligand Org 27569
- (2012) Jonathan F. Fay et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal Structure of a Lipid G Protein-Coupled Receptor
- (2012) M. A. Hanson et al. SCIENCE
- Identification of Essential Cannabinoid-binding Domains
- (2011) Joong-Youn Shim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- MolProbity: all-atom structure validation for macromolecular crystallography
- (2009) Vincent B. Chen et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Dual Role of the Second Extracellular Loop of the Cannabinoid Receptor 1: Ligand Binding and Receptor Localization
- (2009) K. H. Ahn et al. MOLECULAR PHARMACOLOGY
- Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice
- (2008) Douglas Osei-Hyiaman et al. JOURNAL OF CLINICAL INVESTIGATION
- Should peripheral CB1 cannabinoid receptors be selectively targeted for therapeutic gain?
- (2008) George Kunos et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats
- (2007) J G Horswill et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
- (2007) A Thomas et al. BRITISH JOURNAL OF PHARMACOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started