Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition

Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex

(2021) Yu-Qi Ping et al.   NATURE

Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes

(2021) Peng Xiao et al.   CELL

Structures of the human dopamine D3 receptor-Gi complexes

(2021) Peiyu Xu et al.   MOLECULAR CELL

Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling

(2021) Hadar Israeli et al.   SCIENCE

Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3–Gi signaling complexes

(2021) Chang Zhao et al.   CELL RESEARCH

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

(2021) Jesse I. Mobbs et al.   PLOS BIOLOGY

Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures

(2020) Tian Hua et al.   CELL

Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex

(2020) Changrui Xing et al.   CELL

Ozanimod: First Approval

(2020) Yvette N. Lamb   DRUGS

The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target

(2020) Mohamed Abu-Farha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Significance of sphingosine-1-phosphate in cardiovascular physiology and pathology

(2020) E. Jozefczuk et al.   PHARMACOLOGICAL RESEARCH

Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR

(2020) Xinyu Xu et al.   CELL RESEARCH

Targeting the SphK-S1P-SIPR Pathway as a Potential Therapeutic Approach for COVID-19

(2020) Eileen M McGowan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex

(2019) Kaavya Krishna Kumar et al.   CELL

Diverse GPCRs exhibit conserved water networks for stabilization and activation

(2019) A. J. Venkatakrishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siponimod: First Global Approval

(2019) Zaina T. Al-Salama   DRUGS

Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

(2019) Andreane Cartier et al.   SCIENCE

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Sphingosine-1-Phosphate Receptor-1 Agonist Sew2871 Causes Severe Cardiac Side Effects and Does Not Improve Microvascular Barrier Breakdown in Sepsis

(2018) Sven Flemming et al.   SHOCK

Structure of the µ-opioid receptor–Gi protein complex

(2018) Antoine Koehl et al.   NATURE

Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P1) Agonists and Future Perspectives

(2017) Alaric J. Dyckman   JOURNAL OF MEDICINAL CHEMISTRY

Selectivity determinants of GPCR–G-protein binding

(2017) Tilman Flock et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1) and receptor-5 (S1P5) agonist with autoimmune disease-modifying activity

(2016) F L Scott et al.   BRITISH JOURNAL OF PHARMACOLOGY

High-resolution crystal structure of the human CB1 cannabinoid receptor

(2016) Zhenhua Shao et al.   NATURE

Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1

(2015) Jill E. Chrencik et al.   CELL

Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy

(2015) Richard L. Proia et al.   JOURNAL OF CLINICAL INVESTIGATION

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

(2014) Yasuyuki Kihara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sphingosine-1-Phosphate and Its Receptors: Structure, Signaling, and Influence

(2013) Hugh Rosen et al.   Annual Review of Biochemistry

Sphingosine 1-phosphate signalling

(2013) K. Mendelson et al.   DEVELOPMENT

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator

(2013) Shifeng Pan et al.   ACS Medicinal Chemistry Letters

Sphingosine 1-Phosphate Receptor Signaling Regulates Proper Embryonic Vascular Patterning

(2012) Karen Mendelson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Fingolimod for Multiple Sclerosis

(2012) Daniel Pelletier et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Fingolimod (FTY720): A Recently Approved Multiple Sclerosis Drug Based on a Fungal Secondary Metabolite

(2011) Cherilyn R. Strader et al.   JOURNAL OF NATURAL PRODUCTS

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Local Not Systemic Modulation of Dendritic Cell S1P Receptors in Lung Blunts Virus-Specific Immune Responses to Influenza

(2008) D. Marsolais et al.   MOLECULAR PHARMACOLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY