Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1

Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor

(2020) Carl-Mikael Suomivuori et al.   SCIENCE

Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR

(2020) Laura M. Wingler et al.   SCIENCE

β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

(2020) Lauren M. Slosky et al.   CELL

Cryo-EM structures of inactive and active GABAB receptor

(2020) Chunyou Mao et al.   CELL RESEARCH

Structural basis of CXC chemokine receptor 2 activation and signalling

(2020) Kaiwen Liu et al.   NATURE

Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20

(2020) David Jonathan Wasilko et al.   Nature Communications

Biased agonism at chemokine receptors

(2020) Dylan Scott Eiger et al.   CELLULAR SIGNALLING

Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1

(2019) Sanchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Conformational transitions of a neurotensin receptor 1–Gi1 complex

(2019) Hideaki E. Kato et al.   NATURE

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis

(2018) Chao Zhang et al.   CELL RESEARCH

A guide to chemokines and their receptors

(2018) Catherine E. Hughes et al.   FEBS Journal

Single particle reconstruction and validation using Bsoft for the map challenge

(2018) J. Bernard Heymann   JOURNAL OF STRUCTURAL BIOLOGY

Biased signalling: from simple switches to allosteric microprocessors

(2018) Jeffrey S. Smith et al.   NATURE REVIEWS DRUG DISCOVERY

Evaluation and extension of the two-site, two-step model for binding and activation of the chemokine receptor CCR1

(2018) Julie Sanchez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV

(2017) Yi Zheng et al.   IMMUNITY

Mechanisms of Regulation of the Chemokine-Receptor Network

(2017) Martin Stone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

(2016) Tarsis F. Brust et al.   Science Signaling

Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria

(2016) Tarsis F. Brust et al.   Science Signaling

Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor

(2015) J. S. Burg et al.   SCIENCE

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

(2015) L. Qin et al.   SCIENCE

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Interaction of Chemokines with their Receptors – From Initial Chemokine Binding to Receptor Activating Steps

(2014) Stefanie Thiele et al.   CURRENT MEDICINAL CHEMISTRY

The Chemokine Receptor CCR1 Is Constitutively Active, Which Leads to G Protein-independent, β-Arrestin-mediated Internalization

(2013) C. Taylor Gilliland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease

(2012) D. J. Dairaghi et al.   BLOOD

Pharmacological modulation of chemokine receptor function

(2011) DJ Scholten et al.   BRITISH JOURNAL OF PHARMACOLOGY

β-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction

(2007) K DeFea   BRITISH JOURNAL OF PHARMACOLOGY