The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease

Sex‐specific alterations in NAD+ metabolism in 3xTg Alzheimer’s disease mouse brain assessed by quantitative targeted LC‐MS

(2021) Vera Velpen et al.   JOURNAL OF NEUROCHEMISTRY

Butyrate Suppresses Glucose Metabolism of Colorectal Cancer Cells via GPR109a-AKT Signaling Pathway and Enhances Chemotherapy

(2021) Hong-Wei Geng et al.   Frontiers in Molecular Biosciences

Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease

(2021) Cameron S. McAlpine et al.   NATURE

INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia

(2021) Andy P. Tsai et al.   NEUROBIOLOGY OF DISEASE

Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system

(2020) Khalil S. Rawji et al.   ACTA NEUROPATHOLOGICA

Plaque-associated myeloid cells derive from resident microglia in an Alzheimer’s disease model

(2020) Erin G. Reed-Geaghan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region

(2020) Kai Schlepckow et al.   EMBO Molecular Medicine

Microglia depletion rapidly and reversibly alters amyloid pathology by modification of plaque compaction and morphologies

(2020) Brad T. Casali et al.   NEUROBIOLOGY OF DISEASE

Control of brain tumor growth by reactivating myeloid cells with niacin

(2020) Susobhan Sarkar et al.   Science Translational Medicine

Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model

(2020) Shoutang Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intraperitoneal injection of IFN-γ restores microglial autophagy, promotes amyloid-β clearance and improves cognition in APP/PS1 mice

(2020) Zitian He et al.   Cell Death & Disease

β-hydroxybutyrate and hydroxycarboxylic acid receptor 2 agonists activate the AKT, ERK and AMPK pathways, which are involved in bovine neutrophil chemotaxis

(2020) María D. Carretta et al.   Scientific Reports

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

(2020) Brittani R. Price et al.   Journal of Neuroinflammation

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

(2019) Carlo Sala Frigerio et al.   Cell Reports

GREIN: An Interactive Web Platform for Re-analyzing GEO RNA-seq Data

(2019) Naim Al Mahi et al.   Scientific Reports

Niacin Ameliorates Neuro-Inflammation in Parkinson’s Disease via GPR109A

(2019) Banabihari Giri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC–ERK1/2–AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet

(2019) Lingyan Ye et al.   JOURNAL OF NUTRITION

Niacin modulates macrophage polarization in Parkinson's disease

(2018) Chandramohan Wakade et al.   JOURNAL OF NEUROIMMUNOLOGY

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer’s disease

(2018) Paul J. Cheng-Hathaway et al.   Molecular Neurodegeneration

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

(2018) Brad A. Friedman et al.   Cell Reports

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

(2018) Alexandra Litvinchuk et al.   NEURON

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy

(2017) Jonathan Cole et al.   Oncotarget

Neuronally-directed effects of RXR activation in a mouse model of Alzheimer’s disease

(2017) M. M. Mariani et al.   Scientific Reports

Young microglia restore amyloid plaque clearance of aged microglia

(2016) Anna Daria et al.   EMBO JOURNAL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

(2016) Peng Yuan et al.   NEURON

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Fumarates modulate microglia activation through a novel HCAR2 signaling pathway and rescue synaptic dysregulation in inflamed CNS

(2015) Benedetta Parodi et al.   ACTA NEUROPATHOLOGICA

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination

(2015) Shweta S. Puntambekar et al.   GLIA

Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson’s disease models are mediated by GPR109A-dependent mechanisms

(2015) Shou-Peng Fu et al.   Journal of Neuroinflammation

Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease

(2015) B. T. Casali et al.   JOURNAL OF NEUROSCIENCE

NAD+ in aging, metabolism, and neurodegeneration

(2015) E. Verdin   SCIENCE

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

(2015) Carlo Condello et al.   Nature Communications

Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors

(2015) Sara Duarte-Pereira et al.   Oncotarget

Novel assay for simultaneous measurement of pyridine mononucleotides synthesizing activities allows dissection of the NAD+biosynthetic machinery in mammalian cells

(2014) Federica Zamporlini et al.   FEBS Journal

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Suppression of Alzheimer-Associated Inflammation by Microglial Prostaglandin-E2 EP4 Receptor Signaling

(2014) N. S. Woodling et al.   JOURNAL OF NEUROSCIENCE

Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases

(2014) M. Narayanan et al.   Molecular Systems Biology

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Galantamine Slows Down Plaque Formation and Behavioral Decline in the 5XFAD Mouse Model of Alzheimer’s Disease

(2014) Soumee Bhattacharya et al.   PLoS One

The β-hydroxybutyrate receptor HCA2 activates a neuroprotective subset of macrophages

(2014) Mahbubur Rahman et al.   Nature Communications

Differential tissue and ligand-dependent signaling of GPR109A receptor: Implications for anti-atherosclerotic therapeutic potential

(2013) Ibragim Gaidarov et al.   CELLULAR SIGNALLING

Niacin, an old drug with a new twist

(2013) Wen-Liang Song et al.   JOURNAL OF LIPID RESEARCH

M-CSF increases proliferation and phagocytosis while modulating receptor and transcription factor expression in adult human microglia

(2013) Amy M Smith et al.   Journal of Neuroinflammation

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Niacin Lipid Efficacy Is Independent of Both the Niacin Receptor GPR109A and Free Fatty Acid Suppression

(2012) B. Lauring et al.   Science Translational Medicine

Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells

(2011) Martina Lukasova et al.   JOURNAL OF CLINICAL INVESTIGATION

Nicotinic acid– and monomethyl fumarate–induced flushing involves GPR109A expressed by keratinocytes and COX-2–dependent prostanoid formation in mice

(2010) Julien Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid-  Phagocytosis

(2010) Z. Liu et al.   JOURNAL OF NEUROSCIENCE

Interferon-γ Differentially Affects Alzheimer’s Disease Pathologies and Induces Neurogenesis in Triple Transgenic-AD Mice

(2009) Michael A. Mastrangelo et al.   AMERICAN JOURNAL OF PATHOLOGY

Niaspan treatment improves neurological functional recovery in experimental autoimmune encephalomyelitis mice

(2008) Jing Zhang et al.   NEUROBIOLOGY OF DISEASE