Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates

Exploring the complex and multifaceted interplay of the gut microbiome and cancer prevention and therapy

(2023) Sukrit Kashyap et al.   ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA

Nimbolide Exhibits Potent Anticancer Activity Through ROS-Mediated ER Stress and DNA Damage in Human Non-small Cell Lung Cancer Cells

(2023) Xi Chen et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Targeted Inhibition of Hsp90 in Combination with Metformin Modulates Programmed Cell Death Pathways in A549 Lung Cancer Cells

(2023) Adria Hasan et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Identifying druggable targets from active constituents of Azadirachta indica A. Juss. for non‐small cell lung cancer using network pharmacology and validation through molecular docking

(2023) Rajat Nath et al.   PHYTOCHEMICAL ANALYSIS

Nimbolide, a Neem Limonoid, Inhibits Angiogenesis in Breast Cancer by Abrogating Aldose Reductase Mediated IGF-1/PI3K/Akt Signaling

(2022) Ramesh Nivetha et al.   Anti-Cancer Agents in Medicinal Chemistry

Targeted Delivery Methods for Anticancer Drugs

(2022) Valery V. Veselov et al.   Cancers

Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis

(2022) Pradip Kumar Jaiswara et al.   ENVIRONMENTAL TOXICOLOGY

Insecticidal Triterpenes in Meliaceae: Plant Species, Molecules, and Activities: Part II (Cipadessa, Melia)

(2022) Meihong Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nimbolide attenuates gut dysbiosis and prevents bacterial translocation by improving intestinal barrier integrity and ameliorating inflammation in hepatocellular carcinoma

(2022) Amit Kumar Ram et al.   PHYTOTHERAPY RESEARCH

Emerging role of human microbiome in cancer development and response to therapy: special focus on intestinal microflora

(2022) Hourieh Sadrekarimi et al.   Journal of Translational Medicine

Design, synthesis and cytotoxic activity studies of alkyne linked analogues of Nimbolide

(2022) Bandari Manga et al.   FITOTERAPIA

Identification of Gedunin from a Phytochemical Depository as a Novel Multidrug Resistance-Bypassing Tubulin Inhibitor of Cancer Cells

(2022) Sami A. Khalid et al.   MOLECULES

Nimbolide enhances the antitumor effect of docetaxel via abrogation of the NF-κB signaling pathway in prostate cancer preclinical models

(2022) Jingwen Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Epoxyazadiradione induced apoptosis/anoikis in triple‐negative breast cancer cells, MDA‐MB‐231, by modulating diverse cellular effects

(2021) Sreerenjini Lakshmi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Natural products in drug discovery: advances and opportunities

(2021) Atanas G. Atanasov et al.   NATURE REVIEWS DRUG DISCOVERY

Involvement of actin cytoskeletal modifications in the inhibition of triple-negative breast cancer growth and metastasis by nimbolide

(2021) Arunkumar Arumugam et al.   Molecular Therapy-Oncolytics

Pharmacoinformatics and molecular dynamics simulation-based phytochemical screening of neem plant (Azadiractha indica) against human cancer by targeting MCM7 protein

(2021) Foysal Ahammad et al.   BRIEFINGS IN BIOINFORMATICS

Nimbolide, a Neem Limonoid, Is a Promising Candidate for the Anticancer Drug Arsenal

(2021) Siddavaram Nagini et al.   JOURNAL OF MEDICINAL CHEMISTRY

iRGD conjugated nimbolide liposomes protect against endotoxin induced acute respiratory distress syndrome

(2021) Venkatesh Pooladanda et al.   Nanomedicine-Nanotechnology Biology and Medicine

The gut microbiome: what the oncologist ought to know

(2021) K. A. Lee et al.   BRITISH JOURNAL OF CANCER

Potential benefits of phytochemicals from Azadirachta indica against neurological disorders

(2021) Rajat Sandhir et al.   NEUROCHEMISTRY INTERNATIONAL

Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis and suppresses B-RAF/p.ERK-mediated in vivo tumor growth

(2021) Nuha Mahmoud et al.   PHYTOMEDICINE

Azadirachtin Attenuates Lipopolysaccharide-Induced ROS Production, DNA Damage, and Apoptosis by Regulating JNK/Akt and AMPK/mTOR-Dependent Pathways in Rin-5F Pancreatic Beta Cells

(2021) Annie John et al.   Biomedicines

Nimbolide-encapsulated PLGA nanoparticles induces Mesenchymal-to-Epithelial Transition by dual inhibition of AKT and mTOR in pancreatic cancer stem cells

(2021) Deepika Singh et al.   TOXICOLOGY IN VITRO

Biological Activities of Gedunin—A Limonoid from the Meliaceae Family

(2020) Teresa M. Braga et al.   MOLECULES

Harnessing the Phytotherapeutic Treasure Troves of the Ancient Medicinal Plant Azadirachta indica (Neem) and Associated Endophytic Microorganisms

(2020) Ravindra N. Kharwar et al.   PLANTA MEDICA

Multilayer capsules encapsulating nimbin and doxorubicin for cancer chemo-photothermal therapy

(2020) Varsha Sharma et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Role of PI3K/AKT pathway in cancer: the framework of malignant behavior

(2020) Ningni Jiang et al.   MOLECULAR BIOLOGY REPORTS

Targeting focal adhesion kinase in cancer cells and the tumor microenvironment

(2020) James M. Murphy et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

(2020) Sankhadip Bose et al.   Cells

Epoxyazadiradione exhibit activities in head and neck squamous cell carcinoma by targeting multiple pathways

(2020) Vipin Rai et al.   APOPTOSIS

Hsp90 inhibitor gedunin causes apoptosis in A549 lung cancer cells by disrupting Hsp90:Beclin-1:Bcl-2 interaction and downregulating autophagy

(2020) Adria Hasan et al.   LIFE SCIENCES

Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis

(2020) Amit Kumar Ram et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Gedunin, A Neem Limonoid in Combination with Epalrestat Inhibits Cancer Hallmarks by Attenuating Aldose Reductase-Driven Oncogenic Signaling in SCC131 Oral Cancer Cells

(2019) Kranthi K.K. Tanagala et al.   Anti-Cancer Agents in Medicinal Chemistry

Nimbolide Represses the Proliferation, Migration, and Invasion of Bladder Carcinoma Cells via Chk2-Mediated G2/M Phase Cell Cycle Arrest, Altered Signaling Pathways, and Reduced Transcription Factors-Associated MMP-9 Expression

(2019) Seung-Shick Shin et al.   Evidence-based Complementary and Alternative Medicine

Four limonoids from Bacillus subtilis-fermented neem seeds and their cytotoxic activity

(2019) Pengcheng Lin et al.   FITOTERAPIA

Estrogen receptor activation in response to Azadirachtin A stimulates osteoblast differentiation and bone formation in mice

(2019) Priyanka Kushwaha et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

(2019) Jessica N. Spradlin et al.   Nature Chemical Biology

Disruption of Epigenetic Silencing in Human Colon Cancer Cells Lines Utilizing a Novel Supercritical CO2 Extract of Neem Leaf (Azadirachta indica)

(2019) ZHIFANG QIU et al.   ANTICANCER RESEARCH

The Highly Pure Neem Leaf Extract, SCNE, Inhibits Tumorigenesis in Oral Squamous Cell Carcinoma via Disruption of Pro-tumor Inflammatory Cytokines and Cell Signaling

(2019) Jay Morris et al.   Frontiers in Oncology

Targeting Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1: A Structure-based Virtual Screening Approach to Find Novel Inhibitors

(2019) Kauê Santana da Costa et al.   Current Computer-Aided Drug Design

Nanodelivery and anticancer effect of a limonoid, nimbolide, in breast and pancreatic cancer cells

(2019) Arjun Patra et al.   International Journal of Nanomedicine

The one thousand and one chaperones of the NF-κB pathway

(2019) Federica Fusella et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway

(2018) Dhiraj Kumar et al.   BMC CANCER

DnaJ homolog subfamily A member1 (DnaJ1) is a newly discovered anti-apoptotic protein regulated by azadirachtin in Sf9 cells

(2018) Benshui Shu et al.   BMC GENOMICS

Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells

(2018) Sandeep Kumar et al.   CANCER LETTERS

Nimbolide induced apoptosis by activating ERK-mediated inhibition of c-IAP1 expression in human hepatocellular carcinoma cells

(2018) Kuan-Chun Hsueh et al.   ENVIRONMENTAL TOXICOLOGY

Protective role of nimbolide against chemotherapeutic drug hydroxyurea induced genetic and oxidative damage in an animal model

(2018) Md Fahim Ahmad et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery

(2018) Nicholas Thomford et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

First report on the pharmacokinetic profile of nimbolide, a novel anticancer agent in oral and intravenous administrated rats by LC/MS method

(2018) Shandilya Mahamuni Baira et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A supercritical CO2 extract of neem leaf (A. indica ) and its bioactive liminoid, nimbolide, suppresses colon cancer in preclinical models by modulating pro-inflammatory pathways

(2018) Mandakini J. Patel et al.   MOLECULAR CARCINOGENESIS

A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

(2018) Sumaira Saleem et al.   PHYTOTHERAPY RESEARCH

Nimbolide epigenetically regulates autophagy and apoptosis in breast cancer

(2018) Venkatesh Pooladanda et al.   TOXICOLOGY IN VITRO

Scaffold diversity-oriented synthesis of limonoid dimers: discovery of an axially chiral agent with in vivo anti-breast cancer activity

(2018) Wan-Shan Li et al.   Organic Chemistry Frontiers

Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3

(2018) Yue Xing et al.   PHARMACOLOGICAL RESEARCH

A Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Nimbolide in Mouse Serum: Application to a Preclinical Pharmacokinetics Study

(2018) Lingzhi Wang et al.   Pharmaceutics

Synthesis of the seco -Limonoid BCD Ring System Identifies a Hsp90 Chaperon Machinery (p23) Inhibitor

(2018) David M. Pinkerton et al.   CHEMISTRY-A EUROPEAN JOURNAL

Role and regulation of proapoptotic Bax in oral squamous cell carcinoma and drug resistance

(2018) Manzar Alam et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer

(2018) Josephraj Sophia et al.   Cell Death & Disease

Cytotoxicity of nimbolide towards multidrug-resistant tumor cells and hypersensitivity via cellular metabolic modulation

(2018) Nuha Mahmoud et al.   Oncotarget

Nimbolide induces apoptosis in human nasopharyngeal cancer cells

(2017) Su-Yu Chien et al.   ENVIRONMENTAL TOXICOLOGY

Management of acute skin toxicity with Hypericum perforatum and neem oil during platinum-based concurrent chemo-radiation in head and neck cancer patients

(2017) Pierfrancesco Franco et al.   MEDICAL ONCOLOGY

Protective effect of gedunin on TLR-mediated inflammation by modulation of inflammasome activation and cytokine production: Evidence of a multitarget compound

(2017) Perla Villani Borges et al.   PHARMACOLOGICAL RESEARCH

Neem ( Azadirachta indica ): An indian traditional panacea with modern molecular basis

(2017) Subash Chandra Gupta et al.   PHYTOMEDICINE

Epoxyazadiradione Purified from the Azadirachta indica Seed Induced Mitochondrial Apoptosis and Inhibition of NFκB Nuclear Translocation in Human Cervical Cancer Cells

(2017) G. Shilpa et al.   PHYTOTHERAPY RESEARCH

Induction of apoptosis in response to improved gedunin by liposomal nano-encapsulation in human non-small-cell lung cancer (NCI-H292) cell line

(2017) Chukwumaobim Daniel Uzochukwuwulu Nwokwu et al.   TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH

In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells

(2017) Luxmiga Tharmarajah et al.   Biomed Research International

Evaluation of Apoptosis and Autophagy Inducing Potential of Berberis aristata, Azadirachta indica, and Their Synergistic Combinations in Parental and Resistant Human Osteosarcoma Cells

(2017) Pracheta Sengupta et al.   Frontiers in Oncology

A new cytotoxic salannin-class limonoid alkaloid from seeds of Azadirachta indica A. Juss

(2017) Jianxun Zhu et al.   CHINESE CHEMICAL LETTERS

Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity

(2017) Anwar Rayan et al.   PLoS One

Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model

(2017) Jaganathan Kowshik et al.   Scientific Reports

Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model

(2016) Jingwen Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Nimbolide inhibits androgen independent prostate cancer cells survival and proliferation by modulating multiple pro-survival signaling pathways

(2016) P. Raja Singh et al.   BIOMEDICINE & PHARMACOTHERAPY

Therapeutics Role ofAzadirachta indica(Neem) and Their Active Constituents in Diseases Prevention and Treatment

(2016) Mohammad A. Alzohairy   Evidence-based Complementary and Alternative Medicine

Inhibition of cell survival and proliferation by nimbolide in human androgen-independent prostate cancer (PC-3) cells: involvement of the PI3K/Akt pathway

(2016) Paulraj Raja Singh et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Potential of neem ( Azadirachta indica L.) for prevention and treatment of oncologic diseases

(2016) Shradha M. Patel et al.   SEMINARS IN CANCER BIOLOGY

Gedunin inhibits pancreatic cancer by altering sonic hedgehog signaling pathway

(2016) Ramadevi Subramani et al.   Oncotarget

Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development

(2016) Lingzhi Wang et al.   Oncotarget

Nimbolide, a neem limonoid inhibits Phosphatidyl Inositol-3 Kinase to activate Glycogen Synthase Kinase-3β in a hamster model of oral oncogenesis

(2016) Josephraj Sophia et al.   Scientific Reports

Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

(2016) Ramadevi Subramani et al.   Scientific Reports

Induction of Autophagy and Apoptosis via PI3K/AKT/TOR Pathways by Azadirachtin A in Spodoptera litura Cells

(2016) Xuehua Shao et al.   Scientific Reports

Identifying Drug-Target Selectivity of Small-Molecule CRM1/XPO1 Inhibitors by CRISPR/Cas9 Genome Editing

(2015) Jasper E. Neggers et al.   CHEMISTRY & BIOLOGY

Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma

(2015) Ju-Fang Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Desacetyl nimbinene inhibits breast cancer growth and metastasis through reactive oxygen species mediated mechanisms

(2015) Arunkumar Arumugam et al.   TUMOR BIOLOGY

Gedunin abrogates aldose reductase, PI3K/Akt/mToR, and NF-κB signaling pathways to inhibit angiogenesis in a hamster model of oral carcinogenesis

(2015) Kranthi Kiran Kishore T et al.   TUMOR BIOLOGY

Induction of cell cycle arrest, DNA damage, and apoptosis by nimbolide in human renal cell carcinoma cells

(2015) Yi-Hsien Hsieh et al.   TUMOR BIOLOGY

Potential Compounds for Oral Cancer Treatment: Resveratrol, Nimbolide, Lovastatin, Bortezomib, Vorinostat, Berberine, Pterostilbene, Deguelin, Andrographolide, and Colchicine

(2015) Saurabh Bundela et al.   PLoS One

Neem components as potential agents for cancer prevention and treatment

(2014) Fang Hao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Nimbolide inhibits IGF-I-mediated PI3K/Akt and MAPK signalling in human breast cancer cell lines (MCF-7 and MDA-MB-231)

(2014) Perumal Elumalai et al.   CELL BIOCHEMISTRY AND FUNCTION

Nimbolide inhibits invasion and migration, and down-regulates uPAR chemokine gene expression, in two breast cancer cell lines

(2014) P. Elumalai et al.   CELL PROLIFERATION

Bioactive Limonoids from the Leaves of Azaridachta indica (Neem)

(2014) Maria J. Gualtieri et al.   JOURNAL OF NATURAL PRODUCTS

DrugTargetSeqR: a genomics- and CRISPR-Cas9–based method to analyze drug targets

(2014) Corynn Kasap et al.   Nature Chemical Biology

Chemopreventive and therapeutic effects of nimbolide in cancer: The underlying mechanisms

(2014) Lakshmi Narendra Bodduluru et al.   TOXICOLOGY IN VITRO

Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia

(2014) K Chitta et al.   Blood Cancer Journal

Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line

(2013) Paulraj Raja Singh et al.   CELL BIOCHEMISTRY AND FUNCTION

Direct Inhibition of Retinoblastoma Phosphorylation by Nimbolide Causes Cell-Cycle Arrest and Suppresses Glioblastoma Growth

(2013) S. Karkare et al.   CLINICAL CANCER RESEARCH

Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment

(2013) S. C. Gupta et al.   CLINICAL CANCER RESEARCH

Neem leaf glycoprotein overcomes indoleamine 2,3 dioxygenase mediated tolerance in dendritic cells by attenuating hyperactive regulatory T cells in cervical cancer stage IIIB patients

(2013) Soumyabrata Roy et al.   HUMAN IMMUNOLOGY

Azadirone, a Limonoid Tetranortriterpene, Induces Death Receptors and Sensitizes Human Cancer Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) through a p53 Protein-independent Mechanism

(2013) Subash C. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis

(2013) Chaitanya A. Patwardhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neem leaf extract induces cell death by apoptosis and autophagy in B-chronic lymphocytic leukemia cells

(2013) Kasyapa S. Chitta et al.   LEUKEMIA & LYMPHOMA

A study on antioxidant and apoptotic effect of Azadirachta Indica (neem) in cases of cervical cancer

(2012) Shaista M. Vasenwala et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells

(2012) Krishnamurthy Kavitha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Novel Anti-inflammatory Activity of Epoxyazadiradione against Macrophage Migration Inhibitory Factor

(2012) Athar Alam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluorinated and rearranged gedunin derivatives

(2012) Yukio Hitotsuyanagi et al.   Phytochemistry Letters

Cytogenetic analyses of Azadirachtin reveal absence of genotoxicity but marked antiproliferative effects in human lymphocytes and CHO cells in vitro

(2012) Pasquale Mosesso et al.   TOXICOLOGY LETTERS

Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway

(2012) P. Elumalai et al.   TOXICOLOGY LETTERS

Evaluation of Effect of Triterpenes and Limonoids on Cell Growth, Cell Cycle and Apoptosis in Human Tumor Cell Lines

(2011) Cristiane M. Cazal et al.   Anti-Cancer Agents in Medicinal Chemistry

Meliaceous Limonoids: Chemistry and Biological Activities

(2011) Qin-Gang Tan et al.   CHEMICAL REVIEWS

Cytotoxic and Apoptosis-Inducing Activities of Limonoids from the Seeds ofAzadirachta indica(Neem)

(2011) Takashi Kikuchi et al.   JOURNAL OF NATURAL PRODUCTS

Melanogenesis Inhibitory, Anti-Inflammatory, and Chemopreventive Effects of Limonoids from the Seeds of Azadirachta indicia A. Juss. (Neem)

(2011) Toshihiro Akihisa et al.   Journal of Oleo Science

Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells

(2011) Suboj Babykutty et al.   MOLECULAR CARCINOGENESIS

A systematic protocol for the characterization of Hsp90 modulators

(2010) Robert L. Matts et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Restoration of dysregulated CC chemokine signaling for monocyte/macrophage chemotaxis in head and neck squamous cell carcinoma patients by neem leaf glycoprotein maximizes tumor cell cytotoxicity

(2010) Krishnendu Chakraborty et al.   Cellular & Molecular Immunology

The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells

(2010) R. Vidya Priyadarsini et al.   FREE RADICAL RESEARCH

Gedunin, a Novel Natural Substance, Inhibits Ovarian Cancer Cell Proliferation

(2010) Siddharth G. Kamath et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Modification of Cysteine 179 of IκBα Kinase by Nimbolide Leads to Down-regulation of NF-κB-regulated Cell Survival and Proliferative Proteins and Sensitization of Tumor Cells to Chemotherapeutic Agents

(2010) Subash C. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antiplasmodial Triterpenoids from the Fruits of Neem,Azadirachta indica

(2010) Giuseppina Chianese et al.   JOURNAL OF NATURAL PRODUCTS

The neem limonoids azadirachtin and nimbolide inhibit hamster cheek pouch carcinogenesis by modulating xenobiotic-metabolizing enzymes, DNA damage, antioxidants, invasion and angiogenesis

(2009) Ramamurthi Vidya Priyadarsini et al.   FREE RADICAL RESEARCH

The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis

(2009) G. Harish Kumar et al.   INVESTIGATIONAL NEW DRUGS

The Azadirachtin Story

(2008) Gemma E. Veitch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Azadirachtin, a scientific gold mine

(2008) E. David Morgan   BIOORGANIC & MEDICINAL CHEMISTRY

Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells

(2008) G. Harish Kumar et al.   INVESTIGATIONAL NEW DRUGS

Gedunin, a Novel Hsp90 Inhibitor: Semisynthesis of Derivatives and Preliminary Structure−Activity Relationships

(2008) Gary E. L. Brandt et al.   JOURNAL OF MEDICINAL CHEMISTRY