Gedunin abrogates aldose reductase, PI3K/Akt/mToR, and NF-κB signaling pathways to inhibit angiogenesis in a hamster model of oral carcinogenesis

Targeting drivers of melanoma with synthetic small molecules and phytochemicals

(2015) Leah Ray Strickland et al.   CANCER LETTERS

The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer

(2015) Seiji Mabuchi et al.   GYNECOLOGIC ONCOLOGY

Targeting the PI3K/AKT/mTOR pathway in squamous cell carcinoma of the head and neck

(2015) Daniel R. Simpson et al.   ORAL ONCOLOGY

Signal Transduction in Cancer

(2015) R. Sever et al.   Cold Spring Harbor Perspectives in Medicine

Ellagic Acid Inhibits VEGF/VEGFR2, PI3K/Akt and MAPK Signaling Cascades in the Hamster Cheek Pouch Carcinogenesis Model

(2014) Jaganathan Kowshik et al.   Anti-Cancer Agents in Medicinal Chemistry

Cytomodulin-1, a synthetic peptide abrogates oncogenic signaling pathways to impede invasion and angiogenesis in the hamster cheek pouch carcinogenesis model

(2014) K. Kavitha et al.   BIOCHIMIE

Targeting PI3K/Akt/mTOR Signaling in Cancer

(2014) Camillo Porta et al.   Frontiers in Oncology

MiR-21 suppresses the anticancer activities of curcumin by targeting PTEN gene in human non-small cell lung cancer A549 cells

(2013) W. Zhang et al.   Clinical & Translational Oncology

The IκB kinase complex in NF-κB regulation and beyond

(2013) Michael Hinz et al.   EMBO REPORTS

Aldose reductase inhibition suppresses colon cancer cell viability by modulating microRNA-21 mediated programmed cell death 4 (PDCD4) expression

(2013) Ashish Saxena et al.   EUROPEAN JOURNAL OF CANCER

Gedunin Inactivates the Co-chaperone p23 Protein Causing Cancer Cell Death by Apoptosis

(2013) Chaitanya A. Patwardhan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting miR-21 for the Therapy of Pancreatic Cancer

(2013) Flavie Sicard et al.   MOLECULAR THERAPY

The importance of oncogenic transcription factors for oral cancer pathogenesis and treatment

(2013) Govinda Raju Yedida et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

PI3K and Akt as molecular targets for cancer therapy: current clinical outcomes

(2012) Ipsita Pal et al.   ACTA PHARMACOLOGICA SINICA

Aldose Reductase Inhibition Prevents Colon Cancer Growth by Restoring Phosphatase and Tensin Homolog Through Modulation of miR-21 and FOXO3a

(2012) Ashish Saxena et al.   ANTIOXIDANTS & REDOX SIGNALING

Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells

(2012) Krishnamurthy Kavitha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Prevention of VEGF-induced growth and tube formation in human retinal endothelial cells by aldose reductase inhibition

(2012) Umesh C.S. Yadav et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Cross-Talk between NFkB and the PI3-Kinase/AKT Pathway Can Be Targeted in Primary Effusion Lymphoma (PEL) Cell Lines for Efficient Apoptosis

(2012) Azhar R. Hussain et al.   PLoS One

Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo

(2011) Ravinder Tammali et al.   ANGIOGENESIS

Aldose Reductase Inhibition Prevents Hypoxia-induced Increase in Hypoxia-inducible Factor-1α (HIF-1α) and Vascular Endothelial Growth Factor (VEGF) by Regulating 26 S Proteasome-mediated Protein Degradation in Human Colon Cancer Cells

(2011) Ravinder Tammali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An essential role for the Id1/PI3K/Akt/NFkB/survivin signalling pathway in promoting the proliferation of endothelial progenitor cells in vitro

(2011) Wei Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression

(2011) Ling-Zhi Liu et al.   PLoS One

Activation of PI3K/Akt/IKK-α/NF-κB signaling pathway is required for the apoptosis-evasion in human salivary adenoid cystic carcinoma: its inhibition by quercetin

(2010) Zhi-Jun Sun et al.   APOPTOSIS

NF-κB targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors

(2010) Vivian Y. Shin et al.   CARCINOGENESIS

The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells

(2010) R. Vidya Priyadarsini et al.   FREE RADICAL RESEARCH

Gedunin, a Novel Natural Substance, Inhibits Ovarian Cancer Cell Proliferation

(2010) Siddharth G. Kamath et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

NF-κB addiction and its role in cancer: ‘one size does not fit all’

(2010) M M Chaturvedi et al.   ONCOGENE

NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy

(2009) Han-Ming Shen et al.   APOPTOSIS

Inhibition of aldose reductase by dietary antioxidant curcumin: Mechanism of inhibition, specificity and significance

(2009) P. Muthenna et al.   FEBS LETTERS

The neem limonoids azadirachtin and nimbolide inhibit hamster cheek pouch carcinogenesis by modulating xenobiotic-metabolizing enzymes, DNA damage, antioxidants, invasion and angiogenesis

(2009) Ramamurthi Vidya Priyadarsini et al.   FREE RADICAL RESEARCH

Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt

(2009) Dong Bai et al.   INTERNATIONAL JOURNAL OF CANCER

The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis

(2009) G. Harish Kumar et al.   INVESTIGATIONAL NEW DRUGS

Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells

(2008) G. Harish Kumar et al.   INVESTIGATIONAL NEW DRUGS